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2,6-DIMETHOXYBENZONITRILE

2,6-DIMETHOXYBENZONITRILE Structure
2,6-DIMETHOXYBENZONITRILE structure
CAS No.
16932-49-3
Chemical Name:
2,6-DIMETHOXYBENZONITRILE
Synonyms
AKOS 227-44;2,6-DIMETHOXYBENZONI;2,6 methoxybenzonitrile;2,6-dimethoxy-benzonitril;2,6-DIMETHOXYBENZONITRILE;Benzonitrile, 2,6-dimethoxy-;2,6-Dimethoxybenzonitrile,97%;2,6-Dimethoxybenzenecarbonitrile
CBNumber:
CB5455607
Molecular Formula:
C9H9NO2
Molecular Weight:
163.17
MDL Number:
MFCD00001788
MOL File:
16932-49-3.mol
MSDS File:
SDS
Last updated:2026-05-28 04:54:29
Product description Number Pack Size Price
2,6-DIMETHOXYBENZONITRILE AldrichCPR R427128 1 unit $197
2,6-DIMETHOXYBENZONITRILE AldrichCPR R427128 1G $179
2,6-Dimethoxybenzonitrile RAA93249 100g $250
2,6-Dimethoxybenzonitrile 98% OR5007 5g $21
2,6-Dimethoxybenzonitrile 98% OR5007 25g $41
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2,6-DIMETHOXYBENZONITRILE Properties

Melting point 119-123 °C
Boiling point 310 °C
Density 1.2021 (rough estimate)
refractive index 1.5300 (estimate)
storage temp. Sealed in dry,Room Temperature
form Crystalline Powder
color Light beige
CAS DataBase Reference 16932-49-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 87MDL7GK9F

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  20/21/22
Safety Statements  36/37-36-26
Hazard Note  Irritant
HS Code  29269095
Toxicity rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 17, 1953.
NFPA 704
1
2 0

2,6-DIMETHOXYBENZONITRILE price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R427128 2,6-DIMETHOXYBENZONITRILE AldrichCPR 16932-49-3 1 unit $197 2026-04-30 Buy
Sigma-Aldrich R427128 2,6-DIMETHOXYBENZONITRILE AldrichCPR 16932-49-3 1G $179 2024-03-01 Buy
Biosynth RAA93249 2,6-Dimethoxybenzonitrile 16932-49-3 100g $250 2026-06-05 Buy
Apolloscientific OR5007 2,6-Dimethoxybenzonitrile 98% 16932-49-3 5g $21 2026-06-04 Buy
Apolloscientific OR5007 2,6-Dimethoxybenzonitrile 98% 16932-49-3 25g $41 2026-06-04 Buy
Product number Packaging Price Buy
R427128 1 unit $197 Buy
R427128 1G $179 Buy
RAA93249 100g $250 Buy
OR5007 5g $21 Buy
OR5007 25g $41 Buy

2,6-DIMETHOXYBENZONITRILE Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 293, 1955
Tetrahedron, 49, p. 10843, 1993 DOI: 10.1016/S0040-4020(01)80238-6

Synthesis

N,N-Dimethylformamide

68-12-2

1,3-Dimethoxybenzene

151-10-0

2,6-DIMETHOXYBENZONITRILE

16932-49-3

At 0 °C, n-butyllithium (1.67 M hexane solution, 2.9 mL, 4.8 mmol) was slowly added dropwise to a tetrahydrofuran (THF, 5 mL) solution of 1,3-dimethoxybenzene (0.55 g, 4.0 mmol). After the reaction mixture was stirred at 0 °C for 2 h, N,N-dimethylformamide (DMF, 0.34 mL, 4.4 mmol) was added and stirring was continued at 0 °C for 2 h. The reaction mixture was then mixed with N,N-dimethylformamide (DMF, 0.34 mL, 4.4 mmol). Subsequently, ammonia solution (8 mL, 120 mmol) and dihydroammonium iodide (DIH, 0.91 g, 2.4 mmol) were added to the reaction system and the mixture was transferred to room temperature and stirred for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium sulfite solution (15 mL) and then extracted with ether (3 x 20 mL). The organic layers were combined, washed with brine and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=3:1) to afford pure 2,6-dimethoxybenzonitrile in 94% yield as a colorless solid.

References

[1] Tetrahedron, 2011, vol. 67, # 5, p. 958 - 964
[2] Synlett, 2010, # 10, p. 1562 - 1566

2,6-DIMETHOXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Benzonitrile N,N-Dimethylformamide 1,3-Dimethoxybenzene 1,3-DIIODO-5,5-DIMETHYLHYDANTOIN Water
Ammonia n-Butyllithium Hexane Tetrahydrofuran

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Preparation Products

Methyl 2,6-dimethoxybenzoate 2,6-Dimethoxybenzylamine

2,6-DIMETHOXYBENZONITRILE Suppliers

Global( 137)Suppliers
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Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14304 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Win-Win chemical CO., Limited 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 2,6-DIMETHOXYBENZONITRILE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,6-DIMETHOXYBENZONITRILE pictures 2026-03-20 2,6-DIMETHOXYBENZONITRILE
16932-49-3
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2,6-Dimethoxybenzonitrile pictures 2024-04-25 2,6-Dimethoxybenzonitrile
16932-49-3
 $30.00-100.00 1kg 99.93% 1000kg per week Ouhuang Engineering Materials (Hubei) Co., Ltd
2,6-DIMETHOXYBENZONITRILE pictures 2019-07-14 2,6-DIMETHOXYBENZONITRILE
16932-49-3
 $1.00 1KG 99% 100kg Career Henan Chemical Co

2,6-DIMETHOXYBENZONITRILE Spectrum

2,6-DIMETHOXYBENZONITRILE(16932-49-3)MS2,6-DIMETHOXYBENZONITRILE(16932-49-3)1HNMR2,6-DIMETHOXYBENZONITRILE(16932-49-3)13CNMR2,6-DIMETHOXYBENZONITRILE(16932-49-3)IR12,6-DIMETHOXYBENZONITRILE(16932-49-3)IR2

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AKOS 227-44 2,6-Dimethoxybenzonitrile,97% 2,6-Dimethoxybenzenecarbonitrile 2,6-DIMETHOXYBENZONI 2,6 methoxybenzonitrile 2,6-dimethoxy-benzonitril Benzonitrile, 2,6-dimethoxy- 2,6-DIMETHOXYBENZONITRILE 16932-49-3 Aromatic Nitriles