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2-BROMO-4-HYDROXYMETHYLTHIAZOLE

2-BROMO-4-HYDROXYMETHYLTHIAZOLE Structure
2-BROMO-4-HYDROXYMETHYLTHIAZOLE structure
CAS No.
5198-86-7
Chemical Name:
2-BROMO-4-HYDROXYMETHYLTHIAZOLE
Synonyms
2-BROMOTHIAZOLE-4-METHANOL;2-Bromo-4-thiazolemethanol;2-Bromo-4-thiazolylmethanol;4-ThiazoleMethanol,2-broMo-;(2-bromothiazol-4-yl)methanol;2-BROMO-4-HYDROXYMETHYLTHIAZOLE;(2-bromo-1,3-thiazol-4-yl)methanol;(2-BROMO-1,3-THIAZOLE-4-YL)METHANOL;2-Bromo-4-(hydroxymethyl)-1,3-thiazole;2-Bromo-4-(hydroxymethyl)-1,3-thiazole97%
CBNumber:
CB5463116
Molecular Formula:
C4H4BrNOS
Molecular Weight:
194.05
MDL Number:
MFCD04115727
MOL File:
5198-86-7.mol
Last updated:2025-07-24 18:13:49
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2-BROMO-4-HYDROXYMETHYLTHIAZOLE Properties

Boiling point 56 °C(Press: 10 Torr)
Density 1.899±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form liquid
pka 12.82±0.10(Predicted)
color Light yellow
CAS DataBase Reference 5198-86-7(CAS DataBase Reference)
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  22
Hazard Note  Irritant/Keep Cold
HS Code  2934100090

2-BROMO-4-HYDROXYMETHYLTHIAZOLE price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SYX00394 2-Bromo-4-hydroxymethylthiazole 5198-86-7 1g $356 2025-07-31 Buy
TRC B688383 2-Bromothiazole-4-methanol 5198-86-7 500mg $65 2021-12-16 Buy
TRC B688383 2-Bromothiazole-4-methanol 5198-86-7 100mg $45 2021-12-16 Buy
SynQuest Laboratories 8H01-9-X0 2-Bromo-4-(hydroxymethyl)-1,3-thiazole 97.0% 5198-86-7 1g $53 2021-12-16 Buy
Matrix Scientific 069441 2-Bromo-4-hydroxymethylthiazole 97% 5198-86-7 5g $331 2021-12-16 Buy
Product number Packaging Price Buy
SYX00394 1g $356 Buy
B688383 500mg $65 Buy
B688383 100mg $45 Buy
8H01-9-X0 1g $53 Buy
069441 5g $331 Buy

2-BROMO-4-HYDROXYMETHYLTHIAZOLE Chemical Properties,Uses,Production

Synthesis

Ethyl 2-bromothiazole-4-carboxylate

100367-77-9

2-BROMO-4-HYDROXYMETHYLTHIAZOLE

5198-86-7

General procedure for the synthesis of 2-bromothiazole-4-methanol from ethyl 2-bromothiazole-4-carboxylate: In a dry reaction flask, ethyl 2-bromothiazole-4-carboxylate (10.0 g, 42.4 mmol, 1 eq.) was dissolved in tetrahydrofuran (200 mL), and sodium borohydride (4.81 g, 127 mmol, 3 eq.), lithium chloride (5.4 g, 130 mmol, 3 eq.), and water (40 mL) were added in sequence. 130 mmol, 3 equiv) and water (40 mL). The resulting two-phase mixture was stirred vigorously at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent 20% ethyl acetate/hexane) to confirm complete consumption of the raw materials. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (200 mL), diluted with the addition of ethyl acetate (200 mL), and the organic and aqueous layers were separated. The aqueous layer was extracted with ethyl acetate (100 mL), the organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2-bromothiazole-4-methanol as a yellow semi-solid (7.82 g, 95% yield). The Rf value of the thin-layer chromatography was 0.2 (silica gel plate, unfolding agent was 20% ethyl acetate/hexane); the 1H NMR and 13C NMR spectra of the product were consistent with those reported in the literature (Wipf and Wang, 2007).

References

[1] Patent: WO2015/57585, 2015, A1. Location in patent: Page/Page column 27; 28
[2] Patent: CN104478866, 2017, B. Location in patent: Paragraph 0281; 0283; 0284
[3] Patent: CN104478869, 2017, B. Location in patent: Paragraph 0142; 0143; 0144; 0145
[4] Patent: WO2017/184624, 2017, A1. Location in patent: Page/Page column 185; 186
[5] Journal of Organic Chemistry, 2016, vol. 81, # 21, p. 10302 - 10320

2-BROMO-4-HYDROXYMETHYLTHIAZOLE Preparation Products And Raw materials

Raw materials

METHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE Ethyl 2-bromothiazole-4-carboxylate Tetrahydrofuran Lithium chloride Water
Sodium borohydride

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Preparation Products

2-BROMO-4-(((TERT-BUTYLDIMETHYLSILYL)OXY)METHYL)THIAZOLE

2-BROMO-4-HYDROXYMETHYLTHIAZOLE Suppliers

Global( 151)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29800 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569266 +86-17392581500 1015@dideu.com China 3969 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10242 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hubei Ipure Biology Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		58

View Lastest Price from 2-BROMO-4-HYDROXYMETHYLTHIAZOLE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-BROMO-4-HYDROXYMETHYLTHIAZOLE pictures 2020-01-03 2-BROMO-4-HYDROXYMETHYLTHIAZOLE
5198-86-7
 US $6.60 / KG 1KG 97%-99% 1kg -1000kg Career Henan Chemical Co

2-BROMO-4-HYDROXYMETHYLTHIAZOLE Spectrum

2-BROMO-4-HYDROXYMETHYLTHIAZOLE(5198-86-7)1HNMR

5198-86-7(2-BROMO-4-HYDROXYMETHYLTHIAZOLE)Related Search:

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2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER METHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE 2-Bromothiazole 4-Hydroxymethylthiazole 2,4-Dibromothiazole-5-methanol
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2-BROMOTHIAZOLE-4-METHANOL (2-BROMO-1,3-THIAZOLE-4-YL)METHANOL 2-BROMO-4-HYDROXYMETHYLTHIAZOLE 2-Bromo-4-(hydroxymethyl)-1,3-thiazole 2-Bromo-4-(hydroxymethyl)-1,3-thiazole 97% (2-bromothiazol-4-yl)methanol (2-bromo-1,3-thiazol-4-yl)methanol (2-bromo-1,3-thiazol-4-yl)methanol(SALTDATA: HCl) 4-ThiazoleMethanol,2-broMo- 2-Bromo-4-thiazolylmethanol 2-Bromo-4-(hydroxymethyl)-1,3-thiazole97% 2-Bromo-4-thiazolemethanol 5198-86-7 C4H4BrNOS blocks Bromides Thiazoles API intermediates