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None

None Structure
None structure
CAS No.
2163056-91-3
Chemical Name:
None
Synonyms
B1-1347;BI-1347 (BI1347);BI-1347, 10 mM in DMSO;1H-Pyrazole-1-acetamide, 4-[4-(4-isoquinolinyl)phenyl]-N,N-dimethyl-;2-(4-(4-(Isoquinolin-4-yl)phenyl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide;BI-1347,None,2-{4-[4-(isoquinolin-4-yl)phenyl]-1H-pyrazol-1-yl}-N,N-dimethylacetamide;BI1347,oral activity,human NK92MI cell,BI-1347,Inhibitor,CDK,mouse splenic NK cell,BI 1347,anti-tumoral activity,inhibit,Cyclin dependent kinase,selectivity
CBNumber:
CB54656561
Molecular Formula:
C22H20N4O
Molecular Weight:
356.42
MDL Number:
MFCD31716761
MOL File:
2163056-91-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
BI-1347 ≥98% 43667 5mg $82
BI-1347 ≥98% 43667 10mg $156
BI-1347 ≥98% 43667 25mg $367
BI-1347 ≥98% 43667 100mg $814
BI-1347 NLD05691 5mg $389.4
More product size
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None Properties

storage temp. Store at -20°C
solubility DMSO:98.0(Max Conc. mg/mL);274.95(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);8.42(Max Conc. mM)
form Solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

None price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 43667 BI-1347 ≥98% 2163056-91-3 5mg $82 2026-04-30 Buy
Cayman Chemical 43667 BI-1347 ≥98% 2163056-91-3 10mg $156 2026-04-30 Buy
Cayman Chemical 43667 BI-1347 ≥98% 2163056-91-3 25mg $367 2026-04-30 Buy
Cayman Chemical 43667 BI-1347 ≥98% 2163056-91-3 100mg $814 2026-04-30 Buy
Biosynth NLD05691 BI-1347 2163056-91-3 5mg $389.4 2026-06-04 Buy
Product number Packaging Price Buy
43667 5mg $82 Buy
43667 10mg $156 Buy
43667 25mg $367 Buy
43667 100mg $814 Buy
NLD05691 5mg $389.4 Buy

None Chemical Properties,Uses,Production

Uses

BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC50=1.1 nM). BI-1347 shows anti-tumoral activity[1][2].

in vivo

BI-1347 (oral gavage; 10 mg/kg; once daily; 30 d) modulates STAT1 S727 phosphorylation and shows anti-tumor activity in vivo[2].
BI-1347 (oral gavage; 10 mg/kg) intermittent schedule and BI-8382 continuous treatment combination treatment increases efficacy compared to each monotherapy in the mammary carcinoma EMT6 model[2].

Animal Model:B16-F10-luc2 syngeneic melanoma model[2]
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg; once daily; 30 d
Result:Reduced phosphorylation of STAT1 S727 for at least 6 h by 60%.
Showed minimal effect on body weight at 10 mg/kg.
Showed lower tumor burden both on day 23 and 29, compared to the control group.

IC 50

CDK8: 1.1 nM (IC50)

References

[1] Harald Engelhardt, et al. New phenylpyrazolylacetamide compounds and derivatives as cdk8/cdk19 inhibitors.
[2] Hofmann MH, et al. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol Cancer Ther. 2020 Apr;19(4):1018-1030. DOI:10.1158/1535-7163.MCT-19-0789

None Preparation Products And Raw materials

Raw materials

Preparation Products

None Suppliers

Global( 58)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Mashilabs (Shanghai) Co.,Ltd. 19916721580 mafarm@126.com China 4538 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Supplier Advantage
TargetMol Chemicals Inc. 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Nanjing Chemlin Chemical Co., Ltd 64
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Mashilabs (Shanghai) Co.,Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Lastest Price from None manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BI-1347 pictures 2026-07-27 BI-1347
2163056-91-3
 $34.00-128.00 99.81% 10g TargetMol Chemicals Inc.
  • BI-1347 pictures
  • BI-1347
    2163056-91-3
  • $34.00-128.00
  • 99.81%
  • TargetMol Chemicals Inc.

None Spectrum

None(2163056-91-3)1HNMR

2163056-91-3(None)Related Search:

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BI-1347 (BI1347) 1H-Pyrazole-1-acetamide, 4-[4-(4-isoquinolinyl)phenyl]-N,N-dimethyl- 2-(4-(4-(Isoquinolin-4-yl)phenyl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide BI-1347,None,2-{4-[4-(isoquinolin-4-yl)phenyl]-1H-pyrazol-1-yl}-N,N-dimethylacetamide BI1347,oral activity,human NK92MI cell,BI-1347,Inhibitor,CDK,mouse splenic NK cell,BI 1347,anti-tumoral activity,inhibit,Cyclin dependent kinase,selectivity BI-1347, 10 mM in DMSO B1-1347 2163056-91-3