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2'-O-Methyladenosine

2'-O-Methyladenosine Structure
2'-O-Methyladenosine structure
CAS No.
2140-79-6
Chemical Name:
2'-O-Methyladenosine
Synonyms
(2R,3R,4R,5R)-5-(6-AMino-9H-purin-9-yl)-2-(hydroxyMethyl)-4-Methoxytetrahydrofuran-3-ol;AMI;cordysinin B;OMe-rA;2'-OMe-A;2'-OMe A;2'-OMe-rA;2'-OMe-Ar;2'-O-Me-dA;2'-O-Me-Ado
CBNumber:
CB5476675
Molecular Formula:
C11H15N5O4
Molecular Weight:
281.27
MDL Number:
MFCD00056002
MOL File:
2140-79-6.mol
MSDS File:
SDS
Last updated:2026-03-06 11:42:52
Product description Number Pack Size Price
2'-O-Methyladenosine >98.0%(HPLC)(T) M2291 1g $491
2'-O-Methyladenosine ≥98% 16936 5mg $32
2'-O-Methyladenosine ≥98% 16936 10mg $57
2'-O-Methyladenosine ≥98% 16936 50mg $115
2'-O-Methyladenosine ≥98% 16936 100mg $195
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2'-O-Methyladenosine Properties

Melting point 200-202 C
Boiling point 623.8±65.0 °C(Predicted)
Density 1.84±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
pka 13.13±0.70(Predicted)
form Powder
color White to Off-white
optical activity -50.5°(C=0.01 g/mL H2O)
Water Solubility Soluble in water.
λmax 259nm(H2O)(lit.)
InChI InChI=1S/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChIKey FPUGCISOLXNPPC-YGHVBYMHSA-N
SMILES OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](OC)[C@@H]1O
CAS DataBase Reference 2140-79-6(CAS DataBase Reference)
FDA UNII 02YX82IHZ5

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
HS Code  29349990

2'-O-Methyladenosine price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M2291 2'-O-Methyladenosine >98.0%(HPLC)(T) 2140-79-6 1g $491 2025-07-31 Buy
Cayman Chemical 16936 2'-O-Methyladenosine ≥98% 2140-79-6 5mg $32 2024-03-01 Buy
Cayman Chemical 16936 2'-O-Methyladenosine ≥98% 2140-79-6 10mg $57 2024-03-01 Buy
Cayman Chemical 16936 2'-O-Methyladenosine ≥98% 2140-79-6 50mg $115 2024-03-01 Buy
Cayman Chemical 16936 2'-O-Methyladenosine ≥98% 2140-79-6 100mg $195 2024-03-01 Buy
Product number Packaging Price Buy
M2291 1g $491 Buy
16936 5mg $32 Buy
16936 10mg $57 Buy
16936 50mg $115 Buy
16936 100mg $195 Buy

2'-O-Methyladenosine Chemical Properties,Uses,Production

Description

2'-O-Methyladenosine (Cordysinin B) is a member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis. It has a role as a fungal metabolite. It is a member of adenosines and an ether. It derives from an adenosine. analogue with antiviral properties, starting material for 2'-O'-methyl nucleotides. Potential metabolite of 2'-O-Me-cAMP.

Chemical Properties

White Solid

Uses

2'-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Uses

Adenosine analog.

Preparation

preparation of 2′-O-Methyladenosine
Methylation of adenosine with methyl iodide in anhydrous alkaline medium
Adenosine is treated with CH3I in an anhydrous alkaline medium at 0°C for 4 h. The major products of this reaction are monomethylated adenosine at either the 2′-O or 3′-O position (total of 64%) and the side products are dimethylated adenosine (2′,3′-O-dimethyladenosi, 21%, and N6-2′-O-dimethyladenosine, 11%). The ratio of 2′-O- and 3′-O-methyladenosine has been found to be 8 to 1. Therefore, this reaction preferentially favors the synthesis of 2′-O-methyladenosine. The monomethylated adenosine is isolated from reaction mixture by a silica gel column chromatography. Then the pure 2′-O-methyladenosine can be separated by crystallization in ethanol from the mixture of 2′-O and 3′-O-methylated isomers. The overall yield of 2′-O-methyladenosine is 42%.
https://doi.org/10.1016/0304-4165(80)90276-7

Definition

2'-O-Methyladenosine is nucleoside modification in which a methyl group is added to the 2' hydroxyl of the ribose moiety of adenosine.

General Description

The 2'-O-Methyladenosine (Am) was showed to be the first nucleotide adjacent to the N7-methylguanosine (m7G) cap and it can be further modified at the N6 position by methylation to generate N6,2’-O-dimethyladenosine (m6Am) (92% chance of being modified), where the structure of m7G5'ppp5'm6AmpNp comprises 20–30% of all the structures[1]. The 2'-O-methyladenosine (Am) modification displaying the lowest level in tumor tissues[2].

Biological Activity

2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities.

References

[1] Qinghai Li, Guohui Wan, Weiling He. “Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers.” Frontiers in Oncology (2021): 586789.
[2] Qihan He. “Correction: FTSJ1 regulates tRNA 2’-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression.” Cell Death & Disease 11 6 (2020): 418.

2'-O-Methyladenosine synthesis

194034-61-2
2140-79-6
Synthesis of 2'-O-Methyladenosine from 6-Chloro-9-(3,5-di-O-acetyl-2-O-methyl-β-D-ribofuranosyl)-9H-purine

2'-O-Methyladenosine Preparation Products And Raw materials

Raw materials

3'-O-Methyl-D-adenosine 6-Chloro-9-(3,5-di-O-acetyl-2-O-methyl-β-D-ribofuranosyl)-9H-purine TRIMETHYLSULFONIUM HYDROXIDE

Preparation Products

Adenosine, N-methyl-3'-O-methyl- (9CI) N(6),O(2)-Dimethyladenosine

2'-O-Methyladenosine Suppliers

Global( 299)Suppliers
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Zhejiang Hengkang Pharmaceutical Co., Ltd.
+86-576-83372028 +86-18868723926 bd1@hengkangpharm.cn China 119 58
Yunbio Tech Co.,Ltd.
+86-010-60605551 +86-18046518538 yunbiochem@126.com China 321 58
INNOBIO PHARM CO.,LTD
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Xinxiang Aurora Biotechnology Co.,Ltd.
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Hangzhou Verychem Science And Technology Co.Ltd 		+86-86-57188162785 13606544505 lucy@verychem.com China 1185 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13797 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29830 58
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Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Nanjing Baifuli Technology Co., Ltd. 		+86-15335185688 sales@unisyn.cn CHINA 332 58
Supplier Advantage
Zhejiang Hengkang Pharmaceutical Co., Ltd.
58
Yunbio Tech Co.,Ltd.
58
INNOBIO PHARM CO.,LTD
58
Xinxiang Aurora Biotechnology Co.,Ltd.
58
Hangzhou Verychem Science And Technology Co.Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Accela ChemBio Inc. 		58
Nanjing Baifuli Technology Co., Ltd. 		58

View Lastest Price from 2'-O-Methyladenosine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'-O-Methyladenosine pictures 2026-03-09 2'-O-Methyladenosine
2140-79-6
 US $0.00 / G 1G 98%min 30kg/month WUHAN FORTUNA CHEMICAL CO., LTD
2'-O-Methyladenosine pictures 2026-03-05 2'-O-Methyladenosine
2140-79-6
 US $106.00-72.00 / mg 99.89% 10g TargetMol Chemicals Inc.
2'-O-Methyladenosine pictures 2026-03-05 2'-O-Methyladenosine
2140-79-6
 US $106.00-72.00 / mg 99.89% 10g TargetMol Chemicals Inc.

2'-O-Methyladenosine Spectrum

2'-O-Methyladenosine(2140-79-6)1HNMR

2140-79-6(2'-O-Methyladenosine)Related Search:

Guanosine NUCLEOSIDE PHOSPHORYLASE BACTERIAL Coenzyme B12 Adenosine Cyclic AMP
S-ADENOSYL-L-METHIONINE Adenine Adenine phosphate salt（1：1） PUROMYCIN AMINONUCLEOSIDE Vidarabine
Adenine Sulfate Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) ADENOSINE 5'-TRIPHOSPHATASE 3-METHYLADENINE 6-Chloropurine ribonucleoside
2''-Deoxy-N6-methyladenosine 5'-Guanylic acid Adenosine Deaminase

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2'-OMe-rA 2'-O-Methyladenosine, 99.0% 2'-O-Me-Ado -O-Methyladenosine 2-Amino-N6-(dimethylaminomethylidene)-N2-isobutyryl-2&rsquo AMI 2'-O-Methyladdenosine (2R,3R,4R,5R)-5-(6-AMino-9H-purin-9-yl)-2-(hydroxyMethyl)-4-Methoxytetrahydrofuran-3-ol 2'-O-Methyl-D-adenosine 5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol 2'-OMe-A (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-methoxy-2-methylol-tetrahydrofuran-3-ol (2R,3R,4R,5R)-5-(6-azanylpurin-9-yl)-2-(hydroxymethyl)-4-methoxy-oxolan-3-ol 2'-OMe Adenosine cordysinin B (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxy-tetrahydrofuran-3-ol 2'-OMe-Ar 2'-O-Methyladenosine> Adenosine, 2'-O-methyl- 2'-O-Methyladenosine USP/EP/BP 2’-O-Methyl adenosine,RNA modified nucleoside Am RNA modified nucleoside Am OMe-rA 2'-O-Methyladenosine 2'-O-Me-dA 2 ' - 0 -Methyladenosine 2'-OMe A 2''-O-Methyladenosine 2''-O-Methyladenosine, 10 mM in DMSO 2'-Methoxyadenosine 2′,-O-Me-Ado 2'-O-methyladenosine 2140-79-6 Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs BioChemical Biochemicals and Reagents Biochemicals and Reagents Nucleoside Analogs Nucleosides, Nucleotides, Oligonucleotides Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleotides Nucleosides Modified（deoxy）nucleoside Nucleosides-2'-OMe Nucleosides