LL-37 Polyclonal Antibody

Description

LL-37 is a cationic α-helical peptide expressed in human bone marrow, testis, granulocytes, gingival epithelium, and a variety of immune cells.1 It is produced by proteolytic cleavage of the cathelicidin human cationic antimicrobial protein of 18 kDa (hCAP18).2 LL-37 has antimicrobial and antiviral activity, and protein levels of LL-37 are increased in epithelial cells, macrophages, and neutrophils following bacterial infection in vitro.1,3,4,5 It functions as a chemoattractant for human monocytes, neutrophils, and T cells, and induces chemokine secretion from epithelial cells in infected tissues.6,2 LL-37 is a component of LPS-induced NETs produced from human neutrophils isolated from patients with systemic lupus erythrematosus (SLE) or individuals without SLE.7 It also enhances PMA- or S. aureus-induced formation of NETs.8 LL-37 can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4, a modification that reduces its antibacterial and antiviral activities.9,5 Native, but not citrullinated, LL-37 prevents mortality in a mouse model of D-galactosamine-sensitized endotoxic shock.9 Cayman's LL-37 Polyclonal Antibody can be used for Western blot.WARNING This product is not for human or veterinary use.