HC≡C-CH2-PEG3-SH
- CAS No.
- 1412905-18-0
- Chemical Name:
- HC≡C-CH2-PEG3-SH
- Synonyms
- HC≡C-CH2-PEG3-SH;Propargyl-PEG3-SH;Ethanethiol, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-;2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethane-1-thiol
- CBNumber:
- CB54868344
- Molecular Formula:
- C9H16O3S
- Molecular Weight:
- 204.29
- MDL Number:
- MFCD31747070
- MOL File:
- 1412905-18-0.mol
HC≡C-CH2-PEG3-SH price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA01K5CX | 2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethanethiol ≥95% | 1412905-18-0 | 100mg | $445 | 2026-05-30 | Buy |
| aablocks | AA01K5CX | 2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethanethiol ≥95% | 1412905-18-0 | 250mg | $645 | 2026-05-30 | Buy |
| aablocks | AA01K5CX | 2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethanethiol ≥95% | 1412905-18-0 | 500mg | $895 | 2026-05-30 | Buy |
| aablocks | AA01K5CX | 2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethanethiol ≥95% | 1412905-18-0 | 1g | $1283 | 2026-05-30 | Buy |
| aablocks | AA01K5CX | 2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethanethiol >96% | 1412905-18-0 | 5g | $4990 | 2026-05-30 | Buy |
HC≡C-CH2-PEG3-SH Chemical Properties, Uses, Production
Uses
Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-SH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
HC≡C-CH2-PEG3-SH Preparation Products And Raw materials
Raw materials
Preparation Products
HC≡C-CH2-PEG3-SH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Minhan Pharmaceutical Technology Co., Ltd. | 17612188245 | 2816925681@qq.com | China | 8316 | 58 |
| Affinity（Wuhan）Ltd. | 15841022315 | sales@affinitytech.cn | China | 2980 | 58 |
| Zhengzhou Converging Chemical Co. LTD | 0371-53399770 18037166334 | 3857571523@qq.com | China | 7173 | 58 |
| Nanjing Bairuikang Biotechnology Co., Ltd. | 18168036974 | wangweicss@126.com | China | 1379 | 58 |
| Shochem(Shanghai)Co.,Ltd | +86-021-50800795 13816874662 | info@shochem.com | China | 500 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Yanfen Biochemical Technology Co.,LTD | 13611955358 15002190549 | yanfen2023@126.com | China | 2573 | 58 |
| Henan Mengtai Pharmaceutical Technology Co., Ltd | 17634413542 | 1959525201@qq.com | China | 9011 | 58 |
| Affinity Linkers Ltd. | 15841022315 15841022315 | sales@affinitytech.cn | China | 7039 | 58 |
