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Trimethylamine N-oxide dihydrate

Trimethylamine N-oxide dihydrate Structure
Trimethylamine N-oxide dihydrate structure
CAS No.
62637-93-8
Chemical Name:
Trimethylamine N-oxide dihydrate
Synonyms
TMO;Trimethylamine N-Oxide-D9;TRIMETHYLAMINE OXIDE DIHYDRATE;TMANO;amine N-oxide;TMANO Dihydrate;Trimethylamine oxid;amine N-oxide dihydrate;trimethylammoniumoxidhydrat;TriMethylaMine N-Oxide 
CBNumber:
CB5487802
Molecular Formula:
C3H13NO3
Molecular Weight:
111.14
MDL Number:
MFCD00149077
MOL File:
62637-93-8.mol
MSDS File:
SDS
Last updated:2026-04-14 09:55:04
Product description Number Pack Size Price
Trimethylamine N-oxide dihydrate 98% T0514 100g $225
Trimethylamine N-Oxide Dihydrate [for Biochemical Research] T4321 5G $57
Trimethylamine N-Oxide Dihydrate >98.0%(T) T0466 25g $49
Trimethylamine N-Oxide Dihydrate [for Biochemical Research] T4321 25G $179
Trimethylamine N-Oxide Dihydrate >98.0%(T) T0466 100g $119
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Trimethylamine N-oxide dihydrate Properties

Melting point 95-99 °C(lit.)
Flash point 95 °C
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Sparingly)
form Fine Crystalline Powder
color White to off-white
Water Solubility Soluble in water, ethanol, dimethyl sulfoxide and methanol. Sparingly soluble in hot chloroform. Insoluble in diethyl ether, benzene and hydrocarbon solvents.
Merck 14,9711
BRN 3612927
Cosmetics Ingredients Functions FRAGRANCE
HUMECTANT
InChI InChI=1S/C3H9NO.2H2O/c1-4(2,3)5;;/h1-3H3;2*1H2
InChIKey PGFPZGKEDZGJQZ-UHFFFAOYSA-N
SMILES [N+]([O-])(C)(C)C.O.O
CAS DataBase Reference 62637-93-8(CAS DataBase Reference)
FDA UNII C73WZ0186W
UNSPSC Code 12352116
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/38-20/21/22
Safety Statements  26-36-37/39
WGK Germany  2
RTECS  YH2850000
F  4.10
TSCA  Yes
HS Code  29211990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
NFPA 704
1
2 0

Trimethylamine N-oxide dihydrate price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T0514 Trimethylamine N-oxide dihydrate 98% 62637-93-8 100g $225 2026-03-19 Buy
TCI Chemical T4321 Trimethylamine N-Oxide Dihydrate [for Biochemical Research] 62637-93-8 5G $57 2026-03-19 Buy
TCI Chemical T0466 Trimethylamine N-Oxide Dihydrate >98.0%(T) 62637-93-8 25g $49 2026-03-19 Buy
TCI Chemical T4321 Trimethylamine N-Oxide Dihydrate [for Biochemical Research] 62637-93-8 25G $179 2026-03-19 Buy
TCI Chemical T0466 Trimethylamine N-Oxide Dihydrate >98.0%(T) 62637-93-8 100g $119 2026-03-19 Buy
Product number Packaging Price Buy
T0514 100g $225 Buy
T4321 5G $57 Buy
T0466 25g $49 Buy
T4321 25G $179 Buy
T0466 100g $119 Buy

Trimethylamine N-oxide dihydrate Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

Trimethylamine N-Oxide Dihydrate is as an oxygen transfer agent used to promote heterometallic cluster catalyzing coordinative hydrogenation. Trimethylamine N-Oxide Dihydrate is also used as a catalyst in the preparation of thermally stable TiO2 nanorod incorporated polymers and semiconductor/metal nanocomposites.

Uses

Oxidizing reagent in organic synthesis.

Uses

Trimethylamine N-oxide dihydrate is used as an oxidizing agent in organic synthesis. It is also used to make quaternary ammonium compounds and a warning agent for flammable gas. Further, it acts as a flavoring agent or adjuvant. It serves as an oxidant for the catalytic osmium tetraoxide cis-hydroxylation of hindered olefins. In addition to this, it is used as a reactant for C-H bond cleavage and decarbonylating agent for solvent-free reactions.

General Description

Trimethylamine N-oxide (TMAO) is an amphiphilic osmolyte that can counteract the denaturing effects of urea, pressure, and ice and stabilize the proteins.

reaction suitability

reagent type: oxidant

in vivo

Trimethylamine N-oxide (TMAO) dihydrate contributes to cardiovascular diseases by promoting inflammatory responses. C57BL/6 mice are fed a normal diet, high-choline diet and/or 3-dimethyl-1-butanol (DMB) diet. The levels of Trimethylamine N-oxide dihydrate and choline are increased in choline-fed mice. Left ventricular hypertrophy, pulmonary congestion, and diastolic dysfunction are markedly exacerbated in heart failure with preserved ejection fraction (HFpEF) mice fed high-choline diets compared with mice fed the control diet. Myocardial fibrosis and inflammation were markedly increased in HFpEF mice fed high-choline diets compared with animals fed the control diet[1].
Trimethylamine N-oxide (dihydrate) can be used in animal modeling to construct models of cardiovascular and metabolic diseases[1].

Induction of cardiovascular and metabolic diseases
Background
Trimethylamine N-oxide (dihydrate) stimulated cardiac hypertrophy, as indicated by increased cell area of cardiomyocytes and expression of hypertrophic markers including atrial natriuretic peptide (ANP) and beta-myosin heavy chain (β-MHC). Additionally, Trimethylamine N-oxide (dihydrate) induced cardiac hypertrophy and cardiac fibrosis in SD rats[2].
Specific Mmodeling Methods
Rats: Wistar male weighing 200-250 g[1]
Administration: 100 μM and 1 mM perfusion or incubation in TMAO-containing buffer solution incubated for 1 h[1]
Mice: CD-1 male weighing 25-30 g 6-8 weeks of age[1]
Administration: 120 mg/kg mixed with drinking water a single dose or daily for 7 days[1]
Note
(1)Rat hearts were perfused, and aortic rings from each experimental animal were immersed in K+-H+ buffer solution with or without the addition of Trimethylamine N-oxide (dihydrate) (100 μM final concentration). After 1 h of perfusion or incubation, the tissue samples were washed to eliminate the residues of TMAO-containing buffer solution and further homogenized with water in an OMNI Bead Ruptor 24 at a w/v ratio of 1:10[1].
(2)All experimental animals were housed under standard conditions (21-23℃, 12-hour light/dark cycle, relative humidity 45-65%) with unlimited access to food (R70 diet) and water[1].
(3)The mice from the first experimental group received Isoproterenol (HY-B1670A) at a dose of 10 μg/mouse, but the animals from the second group received Isoproterenol (HY-B1670A) and Trimethylamine N-oxide (dihydrate) at doses of 10 μg/mouse and 120 mg/kg, respectively. After 30 min, the experimental animals were anesthetized with isoflurane once more to record the cardiac response to acute cardiac stress and the impact of Trimethylamine N-oxide (dihydrate) on the inotropic and chronotropic effects. For the next seven days, the mice in the second group received Trimethylamine N-oxide (dihydrate) together with drinking water at a dose of 120 mg/kg, while the animals from the first group received pure drinking water[1].
Modeling Indicators
Molecular changes: The addition of 100 μM Trimethylamine N-oxide (dihydrate) to the buffer solution increased the content of Trimethylamine N-oxide (dihydrate) in cardiac tissue by three and in the aortic rings by two points five times[1].
Pathology change: Trimethylamine N-oxide (dihydrate) had no influence on Isoproterenol (HY-B1670A)-induced increase on left ventricular ejection fraction, fractional shortening and heart rate[1].
Histological analysis: Promote myocardial hypertrophy, fibrosis, and inflammation in a model of cardiovascular disease (CVD)[3].
Correlated Product(s):Isoproterenol (HY-B1670A)
3,3-dimethyl-1-butanol (HY-W012977)

IC 50

Human Endogenous Metabolite; NLRP3; Microbial Metabolite

Trimethylamine N-oxide dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Trimethylamine N-oxide dihydrate Suppliers

Global( 283)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dideu Industries Group Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from Trimethylamine N-oxide dihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trimethylamine N-oxide dihydrate pictures 2026-04-13 Trimethylamine N-oxide dihydrate
62637-93-8
 US $0.00 / removed 98.75% 10g TargetMol Chemicals Inc.
Trimethylamine N-oxide dihydrate pictures 2026-03-20 Trimethylamine N-oxide dihydrate
62637-93-8
 US $10.00 / kg 1kg 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
Trimethylamine N-oxide dihydrate pictures 2025-11-18 Trimethylamine N-oxide dihydrate
62637-93-8
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited

Trimethylamine N-oxide dihydrate Spectrum

Trimethylamine N-oxide dihydrate(62637-93-8)1HNMRTrimethylamine N-oxide dihydrate(62637-93-8)RamanTrimethylamine N-oxide dihydrate(62637-93-8)IRTrimethylamine N-oxide dihydrate(62637-93-8)FT-IR

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