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4-Hydroxy-6-(trifluoromethyl)pyrimidine

4-Hydroxy-6-(trifluoromethyl)pyrimidine structure

CAS No.: 1546-78-7

Chemical Name:: 4-Hydroxy-6-(trifluoromethyl)pyrimidine

Synonyms: 6-TRIFLUOROMETHYL-4-PYRIMIDINOL;6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL;4-PYRIMIDINOL, 6-(TRIFLUOROMETHYL)-;6-Trifluoromethyl-4(1H)-pyrimidinone;6-TRIFLUOROMETHYL-4-PYRIMIDINOL 98+%;4-HYDROXY-6-TRIFLUOROMETHYLPYRIMIDINE;6-trifluoromethyl-4-hydroxypyrimidine;4-Hydroxy-6-(trifluormethyl)-pyrimidin;6-(trifluoromethyl)pyrimidin-4(3H)-one;6-(trifluoromethyl)-1H-pyrimidin-4-one

CBNumber:: CB5488081

Molecular Formula:: C5H3F3N2O

Molecular Weight:: 164.09

MDL Number:: MFCD00192530

MOL File:: 1546-78-7.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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4-Hydroxy-6-(trifluoromethyl)pyrimidine Properties

Melting point	169-171 °C(lit.)
Boiling point	130.3±50.0 °C(Predicted)
Density	1.55±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	6.41±0.40(Predicted)
form	Crystalline
color	White
Water Solubility	Solubility in methanol (almost transparency). Slightly soluble in water.
BRN	145548
CAS DataBase Reference	1546-78-7(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29335990

NFPA 704

	1
2		0

4-Hydroxy-6-(trifluoromethyl)pyrimidine price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	385344	4-Hydroxy-6-(trifluoromethyl)pyrimidine 99%	1546-78-7	1g	$43.3	2023-01-07	Buy
TCI Chemical	T1601	6-Trifluoromethyl-4-pyrimidinol >98.0%(GC)(T)	1546-78-7	5g	$36	2024-03-01	Buy
TCI Chemical	T1601	6-Trifluoromethyl-4-pyrimidinol >98.0%(GC)(T)	1546-78-7	25g	$129	2024-03-01	Buy
Alfa Aesar	H64381	4-Hydroxy-6-(trifluoromethyl)pyrimidine, 97%	1546-78-7	1g	$31.4	2023-06-20	Buy
Alfa Aesar	H64381	4-Hydroxy-6-(trifluoromethyl)pyrimidine, 97%	1546-78-7	5g	$141	2023-06-20	Buy

Product number	Packaging	Price	Buy
385344	1g	$43.3	Buy
T1601	5g	$36	Buy
T1601	25g	$129	Buy
H64381	1g	$31.4	Buy
H64381	5g	$141	Buy

4-Hydroxy-6-(trifluoromethyl)pyrimidine Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

4-Hydroxy-6-(trifluoromethyl)pyrimidine is used as building block in chemical synthesis. Attributes Development Product Contact

Uses

4-Hydroxy-6-(trifluoromethyl)pyrimidine (6-(Trifluoromethyl)-4-pyrimidinol) may be used in the synthesis of 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 5744, 1958 DOI: 10.1021/ja01554a041

General Description

4-Hydroxy-6-(trifluoromethyl)pyrimidine, a pyrimidine derivative, is a heterocyclic building block.

4-Hydroxy-6-(trifluoromethyl)pyrimidine synthesis

Synthesis of 4-Hydroxy-6-(trifluoromethyl)pyrimidine from FORMAMIDINE HYDROCHLORIDE and Ethyl 4,4,4-trifluoroacetoacetate

4-Hydroxy-6-(trifluoromethyl)pyrimidine Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Hexane Ethanol Formamidine acetate Sodium sulfate

Sodium FORMAMIDINE HYDROCHLORIDE Ethyl acetate Hydrochloric acid Methanol

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Preparation Products

4-Chloro-6-trifluoromethylpyrimidine

4-Hydroxy-6-(trifluoromethyl)pyrimidine Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29856	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	20103	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1087@dideu.com	China	3292	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from 4-Hydroxy-6-(trifluoromethyl)pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	4-Hydroxy-6-(trifluoromethyl)pyrimidine 1546-78-7	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2025-01-03	4-Hydroxy-6-(trifluoromethyl)pyrimidine 1546-78-7	US $1.00-900.00 / KG	1g	98%	50ton	Shaanxi Dideu Medichem Co. Ltd
2021-12-07	4-Hydroxy-6-(trifluoromethyl)pyrimidine 1546-78-7	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

4-Hydroxy-6-(trifluoromethyl)pyrimidine
1546-78-7
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

4-Hydroxy-6-(trifluoromethyl)pyrimidine
1546-78-7
US $1.00-900.00 / KG
98%
Shaanxi Dideu Medichem Co. Ltd

4-Hydroxy-6-(trifluoromethyl)pyrimidine
1546-78-7
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-Hydroxy-6-(trifluoromethyl)pyrimidine Spectrum

4-Hydroxy-6-(trifluoromethyl)pyrimidine(1546-78-7)MS 4-Hydroxy-6-(trifluoromethyl)pyrimidine(1546-78-7)¹HNMR 4-Hydroxy-6-(trifluoromethyl)pyrimidine(1546-78-7)¹³CNMR 4-Hydroxy-6-(trifluoromethyl)pyrimidine(1546-78-7)IR1 4-Hydroxy-6-(trifluoromethyl)pyrimidine(1546-78-7)IR2

1546-78-7(4-Hydroxy-6-(trifluoromethyl)pyrimidine)Related Search:

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Trifluoromethanesulfonic acid Trifluridine 4-HYDROXY-2-(METHYLTHIO)-6-(TRIFLUOROMETHYL)PYRIMIDINE 4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE-2-THIOL 2-Hydroxy-4-(trifluoromethyl)pyrimidine

ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-Hydroxy-2-(trifluoromethyl)pyrimidine 2-AMINO-4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE

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6-TRIFLUOROMETHYL-4-PYRIMIDINOL 6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL 4-HYDROXY-6-TRIFLUOROMETHYLPYRIMIDINE 4-PYRIMIDINOL, 6-(TRIFLUOROMETHYL)- 4-Hydroxy-6-(trifluormethyl)-pyrimidin 6-TRIFLUOROMETHYL-4-PYRIMIDINOL 98+% 6-Trifluoromethyl-4(1H)-pyrimidinone 4-Hydroxy-6-(trifluoromethyl)pyrimidine ,98% 4(3H)-PyriMidinone, 6-(trifluoroMethyl)- 4-Hydroxy-6-(trifluoromethyl)pyrimidine 6-(Trifluoromethyl)pyrimidin-4-ol 4-Hydroxy-6-(trifluoromethyl)pyrimidine 99% 6-(trifluoromethyl)pyrimidin-4(3H)-one 6-trifluoromethyl-4-hydroxypyrimidine 6-(trifluoromethyl)-1H-pyrimidin-4-one 4-Hydroxy-6-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH 6-(Trifluoromethyl)-4(3H)-pyrimidinone 1546-78-7 Heterocyclic Building Blocks Pyrimidines Building Blocks Boronic Acid Heterocyclic Compounds Fluorinated pyrimidine derivatives Pyrimidines Pyrimidine series alcohol Fluorine series