Dermorphin
- CAS No.
- 77614-16-5
- Chemical Name:
- Dermorphin
- Synonyms
- DERMORPHIN;Dermorphin 5mg;Dermorphin HAc;Dermorphin Powder;DERMORPHIN ACETATE;dermorphin/DERMORPHIN ACETATE;Dermorphin trifluoroacetate salt;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro
- CBNumber:
- CB5498044
- Molecular Formula:
- C40H50N8O10
- Molecular Weight:
- 802.87
- MDL Number:
- MFCD00076694
- MOL File:
- 77614-16-5.mol
- MSDS File:
- SDS
| Melting point | 157-159 °C |
|---|---|
| Boiling point | 1323.8±65.0 °C(Predicted) |
| Density | 1.363±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO |
| pka | 9.83±0.15(Predicted) |
| form | powder |
| color | white to off-white |
| Sequence | H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 |
| InChIKey | FHZPGIUBXYVUOY-VWGYHWLBSA-N |
| SMILES | C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1 |
| FDA UNII | 2SEC01B703 |
Dermorphin price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-7103 | Dermorphin 99.64% | 77614-16-5 | 10mg | $216 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD108711 | Dermorphin | 77614-16-5 | 250mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD108711 | Dermorphin | 77614-16-5 | 500mg | $375 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0001209 | DERMORPHIN 95.00% | 77614-16-5 | 1MG | $427.2 | 2021-12-16 | Buy |
| ChemScene | CS-7103 | Dermorphin 99.64% | 77614-16-5 | 25mg | $468 | 2021-12-16 | Buy |
Dermorphin Chemical Properties,Uses,Production
Structure
Dermorphin does not contain the common N-terminal sequence for the traditional endogenous opioid peptides (Tyr–Gly–Gly–Phe), and its sequence is completely different from those of the endomorphins, which were identified as endogenous μ-opioid peptides that also do not contain the common sequence. Interestingly, DM contains D-alanine (a D-isomer amino acid) in its sequence. The primary structure of dermorphin is YDAFGYPS-NH2.
Description
Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu-opioid receptors.
Uses
A mu-opioid receptor agonist
Definition
ChEBI: Dermorphin is an oligopeptide.
Side effects
Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than morphine does[1].
in vitro
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.
References
[1] Negri, L. P. Melchiorri and R. Lattanzi. “Opioid and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.
Dermorphin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yimeixin Technology Co., LTD | China | 195 | 58 | ||
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1085 | 58 |
| Hebei Weimiao Import and Export Trade Co., Ltd. | +86-19948166995 | sale01@hbweimiao.com | China | 76 | 58 |
| Hebei Xunou new energy Technology Co., LTD | +86-17531957005; +undefined17531957005 | xunou8@hbxunou.com | China | 36 | 58 |
| Strong peptide cross-border e-commerce Co. LTD | +undefined13930052870 | qt01@qiangtaipharm.com | China | 84 | 58 |
| Shenzhen Aoxi Technology Co., Ltd. | +852-46424790 | frank88rawpowder@outlook.com | China | 161 | 58 |
| Hebei Sidaner Technology Co., Ltd. | +86-86-15732938890 +8615732938890 | 18631999880a@gmail.com | China | 113 | 58 |
| TsurgeX Pharmaceutical Technology Co., Ltd. | +8613393959797 | master@tsurgex.com | China | 44 | 58 |
| GUANGZHOU SHENGYOU IM&EX CO,.LTD | +8615373916629 | AlexDowson@163.com | China | 114 | 58 |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3390 | 58 |
View Lastest Price from Dermorphin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-04 | DERMORPHIN ACETATE
77614-16-5
|
US $1.00 / g | 1g | 99% | 100kg | RongNa Biotechnology Co.,Ltd | |
 |
2025-10-04 | Dermorphin 5mg
77614-16-5
|
US $30.00-10.00 / kit | 1kit | 99% | 10000kits | Shenzhen Aoxi Technology Co., Ltd. | |
 |
2025-10-01 | dermorphin
77614-16-5
|
US $20.00 / box | 1box | 99 | in stock | Ningbo Qingteng Plastic Cost.,Ltd. |
-
- DERMORPHIN ACETATE
77614-16-5
- US $1.00 / g
- 99%
- RongNa Biotechnology Co.,Ltd
-
- Dermorphin 5mg
77614-16-5
- US $30.00-10.00 / kit
- 99%
- Shenzhen Aoxi Technology Co., Ltd.
-
- dermorphin
77614-16-5
- US $20.00 / box
- 99
- Ningbo Qingteng Plastic Cost.,Ltd.
