1400 W DIHYDROCHLORIDE, 96
- CAS No.
- 214358-33-5
- Chemical Name:
- 1400 W DIHYDROCHLORIDE, 96
- Synonyms
- 1400W2HCl;CAS:214358-33-5;1400W, iNOS inhibitor;1400W (hydrochloride);1400 W DIHYDROCHLORIDE, 96;1400W dihydrochloride, 10 mM in DMSO;1400W - CAS 214358-33-5 - Calbiochem;N-(3-(aMinoMethyl)benzyl)acetiMidaMide dihydrochloride;N-[3-(AMinoMethyl)benzyl]ethaniMidaMide dihydrochloride;inhibit,1400W dihydrochloride,NO Synthase,NOS,Nitric oxide synthases,1400W,Inhibitor
- CBNumber:
- CB5502105
- Molecular Formula:
- C8H11NO
- Molecular Weight:
- 137.17904
- MDL Number:
- MFCD03428622
- MOL File:
- 214358-33-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1400W dihydrochloride >98%, solid | W4262 | 10mg | $172 |
| 1400W | 100050 | 5mg | $192 |
| 1400W (hydrochloride) ≥98% | 81520 | 5mg | $54 |
| 1400W (hydrochloride) ≥98% | 81520 | 10mg | $98 |
| 1400W (hydrochloride) ≥98% | 81520 | 50mg | $410 |
| More product size | |||
| Melting point | 208 °C |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in Water (up to 25 mg/ml). |
| form | White solid |
| color | White |
| Water Solubility | Soluble to 100 mM in water |
| Stability | Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day. |
| FDA UNII | K1BH573TYJ |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| HS Code | 29242998 |
1400 W DIHYDROCHLORIDE, 96 price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W4262 | 1400W dihydrochloride >98%, solid | 214358-33-5 | 10mg | $172 | 2025-07-31 | Buy |
| Sigma-Aldrich | 100050 | 1400W | 214358-33-5 | 5mg | $192 | 2025-07-31 | Buy |
| Cayman Chemical | 81520 | 1400W (hydrochloride) ≥98% | 214358-33-5 | 5mg | $54 | 2024-03-01 | Buy |
| Cayman Chemical | 81520 | 1400W (hydrochloride) ≥98% | 214358-33-5 | 10mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 81520 | 1400W (hydrochloride) ≥98% | 214358-33-5 | 50mg | $410 | 2024-03-01 | Buy |
1400 W DIHYDROCHLORIDE, 96 Chemical Properties,Uses,Production
Description
1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3?(Ki?= 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1?1400W is cell permeable and active?in vivo.2
Chemical Properties
white to off-white powder
Uses
A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.
Uses
1400W dihydrochloride has been used:
- as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
- as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
- to study its efficacy on renal ischemia/ reperfusion injury in rats
- as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation
General Description
A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at RT
References
[1] E P GARVEY. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo.[J]. The Journal of Biological Chemistry, 1997, 272 8: 4959-4963. DOI:10.1074/jbc.272.8.4959
[2] L L THOMSEN. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.[J]. Cancer research, 1997, 57 15: 3300-3304.
[3] B PIGOTT J G K Bartus. On the selectivity of neuronal NOS inhibitors[J]. British Journal of Pharmacology, 2012, 168 5: 1255-1265. DOI:10.1111/bph.12016
1400 W DIHYDROCHLORIDE, 96 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from 1400 W DIHYDROCHLORIDE, 96 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-09 | 1400W dihydrochloride
214358-33-5
|
US $43.00-127.00 / mg | 100.00% | 10g | TargetMol Chemicals Inc. |
-
- 1400W dihydrochloride
214358-33-5
- US $43.00-127.00 / mg
- 100.00%
- TargetMol Chemicals Inc.
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