TG003
- CAS No.
- 300801-52-9
- Chemical Name:
- TG003
- Synonyms
- CS-955;CS-1704;(E/Z)-TG003;TG003/TG-003;TG003 ，S7320;TG003 USP/EP/BP;(E/Z)-TG003, 10 mM in DMSO;Cdc2-Like Kinase Inhibitor, TG003;1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-
- CBNumber:
- CB5505045
- Molecular Formula:
- C13H15NO2S
- Molecular Weight:
- 249.33
- MDL Number:
- MFCD00624584
- MOL File:
- 300801-52-9.mol
| Product description | Number | Pack Size | Price |
| TG003 ≥98% (HPLC) | T5575 | 5mg | $191.9 |
| TG003 ≥98% (HPLC) | T5575 | 25mg | $800 |
| TG003 ≥95% | 10398 | 1mg | $23 |
| TG003 ≥95% | 10398 | 5mg | $100 |
| TG003 ≥95% | 10398 | 10mg | $177 |
| More product size | |||
| Melting point | 132-132.5 °C |
|---|---|
| Boiling point | 386.0±42.0 °C(Predicted) |
| Density | 1.237±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 33 mg/mL |
| pka | -1.76±0.20(Predicted) |
| form | solid |
| color | pale yellow |
| Sensitive | Light Sensitive |
| InChI | 1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7- |
| InChIKey | BGVLELSCIHASRV-QPEQYQDCSA-N |
| SMILES | CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
TG003 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T5575 | TG003 ≥98% (HPLC) | 300801-52-9 | 5mg | $191.9 | 2025-07-31 | Buy |
| Sigma-Aldrich | T5575 | TG003 ≥98% (HPLC) | 300801-52-9 | 25mg | $800 | 2025-07-31 | Buy |
| Cayman Chemical | 10398 | TG003 ≥95% | 300801-52-9 | 1mg | $23 | 2024-03-01 | Buy |
| Cayman Chemical | 10398 | TG003 ≥95% | 300801-52-9 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 10398 | TG003 ≥95% | 300801-52-9 | 10mg | $177 | 2024-03-01 | Buy |
TG003 Chemical Properties,Uses,Production
Description
Cdc2-
Uses
TG003 has been used in PAC1 cell culture and in vitro kinase assays.
Uses
TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.
Uses
Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Reports show that TG003 modifies the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro, and rescues defects in the development of Xenopus caused by an overabundance of Clk activity.
Biochem/physiol Actions
TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.
References
[1] MICHIKO MURAKI. Manipulation of alternative splicing by a newly developed inhibitor of Clks.[J]. The Journal of Biological Chemistry, 2004: 24246-24254. DOI: 10.1074/jbc.m314298200
TG003 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 19681 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8498 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from TG003 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-05 | (E/Z)-TG003
300801-52-9
|
US $48.00-167.00 / mg | 98.73% | 10g | TargetMol Chemicals Inc. |
-
- (E/Z)-TG003
300801-52-9
- US $48.00-167.00 / mg
- 98.73%
- TargetMol Chemicals Inc.
