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TYRPHOSTIN AG 1024

TYRPHOSTIN AG 1024 Structure
TYRPHOSTIN AG 1024 structure
CAS No.
65678-07-1
Chemical Name:
TYRPHOSTIN AG 1024
Synonyms
CS-241;AGS 200;HY-10253;Tyrphostin;AG-1024 ，S1234;AG-1024 (Tyrphostin);AG1024, 10 mM in DMSO;AG1024; TYRPHOSTIN AG 1024;TYRPHOSTIN AG 1024 USP/EP/BP;AG-1024;TYRPHOSTIN AG1024;AGS 200
CBNumber:
CB5505050
Molecular Formula:
C14H13BrN2O
Molecular Weight:
305.17
MDL Number:
MFCD02179365
MOL File:
65678-07-1.mol
MSDS File:
SDS
Last updated:2025-10-31 16:30:25
Product description Number Pack Size Price
AG 1024 121767 1mg $116
AG 1024 ≥98% 14833 1mg $49
AG 1024 ≥98% 14833 5mg $85
AG 1024 ≥98% 14833 10mg $143
TyrphostinAG1024 T923510 1mg $45
More product size
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TYRPHOSTIN AG 1024 Properties

storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: soluble
form solid
color yellow
FDA UNII NF4XN6A8V9
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3

TYRPHOSTIN AG 1024 price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 121767 AG 1024 65678-07-1 1mg $116 2025-07-31 Buy
Cayman Chemical 14833 AG 1024 ≥98% 65678-07-1 1mg $49 2024-03-01 Buy
Cayman Chemical 14833 AG 1024 ≥98% 65678-07-1 5mg $85 2024-03-01 Buy
Cayman Chemical 14833 AG 1024 ≥98% 65678-07-1 10mg $143 2024-03-01 Buy
TRC T923510 TyrphostinAG1024 65678-07-1 1mg $45 2021-12-16 Buy
Product number Packaging Price Buy
121767 1mg $116 Buy
14833 1mg $49 Buy
14833 5mg $85 Buy
14833 10mg $143 Buy
T923510 1mg $45 Buy

TYRPHOSTIN AG 1024 Chemical Properties,Uses,Production

Description

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM.

Uses

Tyrphostin AG 1024 is an insulin-like growth factor (IGF)-I receptor antagonist.

Definition

ChEBI: 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile is an alkylbenzene.

in vivo

AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth[1].

Animal Model:Female nude mice (6-8 weeks old)[1]
Dosage:30 μg
Administration:IP; per day; for 2 weeks
Result:Significantly delayed the tumour growth.

target

IGF-1R

References

[1] párrizas m1, gazit a, levitzki a, wertheimer e, leroith d. specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. endocrinology. 1997 apr;138(4):1427-33.
[2] fan p1, agboke fa1, mcdaniel re1, sweeney ee1, zou x1, creswell k1, jordan vc2.inhibition of c-src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. eur j cancer. 2014 jan; 50(2):457-68.

TYRPHOSTIN AG 1024 Preparation Products And Raw materials

Raw materials

Preparation Products

TYRPHOSTIN AG 1024 Suppliers

Global( 117)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29850 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20284 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24727 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9984 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Coresyn Pharmatech Co., Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58

View Lastest Price from TYRPHOSTIN AG 1024 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AG1024 pictures 2025-10-31 AG1024
65678-07-1
 US $52.00-163.00 / mg 99.23% 10g TargetMol Chemicals Inc.
TYRPHOSTIN AG 1024 pictures 2019-09-02 TYRPHOSTIN AG 1024
65678-07-1
 US $1.00 / KG 1KG 98% 1lg; 2kg; 5kg; 10kg; 100kg Career Henan Chemical Co
  • AG1024 pictures
  • AG1024
    65678-07-1
  • US $52.00-163.00 / mg
  • 99.23%
  • TargetMol Chemicals Inc.

TYRPHOSTIN AG 1024 Spectrum

TYRPHOSTIN AG 1024(65678-07-1)1HNMR

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AG1024; TYRPHOSTIN AG 1024 AG 1024 - CAS 65678-07-1 - Calbiochem CS-241 2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200 Tyrphostin 2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200 AG-1024;HY-10253; AG 1024; AGS 200 HY-10253 AG-1024 (Tyrphostin) 2-(3-broMo-5-tert-butyl-4-hydroxybenzylidene)Malononitrile AG-1024;TYRPHOSTIN AG1024;AGS 200 Propanedinitrile, 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]- TYRPHOSTIN AG 1024 USP/EP/BP AG-1024 Selective IGF-1R inhibitor AG1024 IGF-1R,IGF1R,DNA-PKcs,phosphorylation,growth,AG1024,Apoptosis,Tyrphostin AG1024,Tyrphostin AG-1024,AG-1024,BCR-ABL,AG 1024,factor-1,Insulin Receptor,anti-cancer,Inhibitor,Akt,inhibit AG1024, 10 mM in DMSO AG-1024 ，S1234 65678-07-1