5-BROMO-2-BENZOXAZOLINONE 97
- CAS No.
- 14733-73-4
- Chemical Name:
- 5-BROMO-2-BENZOXAZOLINONE 97
- Synonyms
- 5-Bromo-benzoxazolinone;5-Bromo-2-benzoxazolone;Venadaparib Impurity 84;5-bromo-2-benzoxazolinon;2-BENZOXAZOLINONE, 5-BROMO-;5-Bromobenzoxazol-2(3H)-one;5-Bromobenzo[d]oxazol-2(3H);5-Bromo-2-hydroxybenzoxazole;5-BROMO-2-BENZOXAZOLINONE 97;5-Bromo-2-benzoxazolinone >
- CBNumber:
- CB5505429
- Molecular Formula:
- C7H4BrNO2
- Molecular Weight:
- 214.02
- MDL Number:
- MFCD01664246
- MOL File:
- 14733-73-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-2-benzoxazolinone 97% | 653454 | 1g | $59 |
| 5-Bromo-2-benzoxazolinone 97% | 653454 | 5g | $157 |
| 5-Bromo-2-benzoxazolinone >98.0%(GC)(T) | B4438 | 1g | $34 |
| 5-Bromo-2-benzoxazolinone >98.0%(GC)(T) | B4438 | 5g | $133 |
| 5-Bromo-2-Benzoxazolinone 99.5+% (HPLC) ≥99.5%(HPLC) | 233942 | 1g | $233 |
| More product size | |||
| Melting point | 218-222 °C(lit.) |
|---|---|
| Boiling point | 10.85°C (rough estimate) |
| Density | 1.809 |
| refractive index | 1.6120 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 8.46±0.70(Predicted) |
| form | powder to crystal |
| color | White to Yellow to Orange |
| InChI | InChI=1S/C7H4BrNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10) |
| InChIKey | DMHTZWJRUUOALC-UHFFFAOYSA-N |
| SMILES | O1C2=CC=C(Br)C=C2NC1=O |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DM4950000 | |||||||||
| HS Code | 2934.99.4400 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
5-BROMO-2-BENZOXAZOLINONE 97 price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 653454 | 5-Bromo-2-benzoxazolinone 97% | 14733-73-4 | 1g | $59 | 2023-06-20 | Buy |
| Sigma-Aldrich | 653454 | 5-Bromo-2-benzoxazolinone 97% | 14733-73-4 | 5g | $157 | 2023-06-20 | Buy |
| TCI Chemical | B4438 | 5-Bromo-2-benzoxazolinone >98.0%(GC)(T) | 14733-73-4 | 1g | $34 | 2026-04-30 | Buy |
| TCI Chemical | B4438 | 5-Bromo-2-benzoxazolinone >98.0%(GC)(T) | 14733-73-4 | 5g | $133 | 2026-04-30 | Buy |
| Usbiological | 233942 | 5-Bromo-2-Benzoxazolinone 99.5+% (HPLC) ≥99.5%(HPLC) | 1g | $233 | 2026-06-03 | Buy |
5-BROMO-2-BENZOXAZOLINONE 97 Chemical Properties,Uses,Production
Chemical Properties
White to off-white crystalline solid
Synthesis
40925-68-6
530-62-1
14733-73-4
General procedure for the synthesis of 5-bromo-2(3H)-benzoxazolone from 2-amino-4-bromophenol and N,N'-carbonyldiimidazole: Referring to Example 2, to a solution of 2-amino-4-bromophenol (3.50 g, 18.6 mmol) in tetrahydrofuran (100 mL) was slowly added N,N'-carbonyldiimidazole (3.62 g, 22.3 mmol). The reaction mixture was heated to reflux for 1.5 hours. Upon completion of the reaction, the reaction solution was cooled to 20-25 °C, acidified by addition of 2N aqueous hydrochloric acid and subsequently extracted with ethyl acetate. The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride, then dried with anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give 5-bromo-1,3-benzoxazol-2(3H)-one (3.89 g, quantitative yield).IR (cm-1): 960, 1149, 1474, 1622, 1751.
References
[1] Patent: EP1719761, 2006, A1. Location in patent: Page/Page column 26
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 18, p. 5568 - 5582
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8191 - 8195
[4] Synthesis (Germany), 2013, vol. 45, # 23, p. 3269 - 3275
[5] Patent: WO2013/64984, 2013, A1. Location in patent: Page/Page column 125
5-BROMO-2-BENZOXAZOLINONE 97 Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9543 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
View Lastest Price from 5-BROMO-2-BENZOXAZOLINONE 97 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 5-BROMO-2-BENZOXAZOLINONE 97
14733-73-4
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 5-BROMO-2-BENZOXAZOLINONE 97
14733-73-4
- $1.00
- 99%
- Career Henan Chemical Co
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