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ChemicalBook >> CAS DataBase List >>2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)-

2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)-

2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- Structure
2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- structure
CAS No.
2052130-80-8
Chemical Name:
2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)-
Synonyms
H3B-6545;H3B6545,H-3B-6545,H3B 6545;(2E)-N,N-dimethyl-4-{[2-({5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]pyridin-2-yl}oxy)ethyl]amino}but-2-enamide;2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)-
CBNumber:
CB55484189
Molecular Formula:
C30H29F4N5O2
Molecular Weight:
567.58
MDL Number:
MFCD31692408
MOL File:
2052130-80-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- Properties

Boiling point 702.0±60.0 °C(Predicted)
Density 1.286±0.06 g/cm3(Predicted)
pka 12.02±0.40(Predicted)
form Solid
color Light yellow to yellow

2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth CHD13080 H3B-6545 2052130-80-8 5mg $1038.4 2026-06-04 Buy
Biosynth CHD13080 H3B-6545 2052130-80-8 10mg $1557.6 2026-06-04 Buy
ChemScene CS-0047714 H3B-6545 99.44% 2052130-80-8 5mg $379 2026-06-04 Buy
ChemScene CS-0047714 H3B-6545 99.44% 2052130-80-8 10mg $650 2026-06-04 Buy
ChemScene CS-0047714 H3B-6545 99.44% 2052130-80-8 50mg $1950 2026-06-04 Buy
Product number Packaging Price Buy
CHD13080 5mg $1038.4 Buy
CHD13080 10mg $1557.6 Buy
CS-0047714 5mg $379 Buy
CS-0047714 10mg $650 Buy
CS-0047714 50mg $1950 Buy

2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- Chemical Properties, Uses, Production

Uses

H3B-6545 is an oral, selective estrogen receptor covalent antagonist (SERCA) for the research of metastatic ER-positive, HER2-negative breast cancer[1][2].

in vivo

In vivo, once daily oral dosing of H3B-6545 shows potent activity and superior efficacy to fulvestrant in the MCF-7 xenograft model with maximal antitumor activity at doses >10x below the maximum tolerated dose in mice. In addition, H3B-6545 shows superior antitumor activity to Tamoxifen and Fulvestrant in patient derived xenograft models of estrogen receptor positive breast cancer including models carrying ERα mutations in rat and monkeys, H3B-6545 is well tolerated across a broad dose range and at exposures that significantly exceed those required for efficacy in mouse xenograft models[1].

References

[1] Peter G. Smith, et al. Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer.AACR Annual Meeting 2017; April 1-5.
[2] Amy H Kim, et al. H3B-6545, a selective estrogen receptor covalent antagonist, prevents bone loss in ovariectomized Sprague-Dawley rats. J Pharmacol Toxicol Methods. Sep-Oct 2019;99:106595.

2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- Suppliers

Global Suppliers ( 25)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 63313187 15358055255 63313187@qq.com China 1982 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9867 58
Wuhan Topule +86-02787215551 19945035818 2936752263@qq.com China 7983 58
Supplier Advantage
BOC Sciences 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
TargetMol Chemicals Inc. 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Wuhan Topule 58

View Latest Price from 2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
H3B-6545 pictures 2026-07-27 H3B-6545
2052130-80-8
 $1130.00 10g TargetMol Chemicals Inc.
H3B-6545 pictures 2026-07-27 H3B-6545
2052130-80-8
 $1130.00 10g TargetMol Chemicals Inc.
H3B-6545 pictures 2025-09-17 H3B-6545
2052130-80-8
 $1130.00 10g TargetMol Chemicals Inc.
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    2052130-80-8
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  • TargetMol Chemicals Inc.
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    2052130-80-8
  • $1130.00
  • TargetMol Chemicals Inc.
  • H3B-6545 pictures
  • H3B-6545
    2052130-80-8
  • $1130.00
  • TargetMol Chemicals Inc.

2052130-80-8 (2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)-) Related Search:

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2-Butenamide, N,N-dimethyl-4-[[2-[[5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]-2-pyridinyl]oxy]ethyl]amino]-, (2E)- H3B-6545 H3B6545,H-3B-6545,H3B 6545 (2E)-N,N-dimethyl-4-{[2-({5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]pyridin-2-yl}oxy)ethyl]amino}but-2-enamide 2052130-80-8 C30H29F4N5O2