dTAG-13
- CAS No.
- 2064175-41-1
- Chemical Name:
- dTAG-13
- Synonyms
- dTAG-13;FKBP12 PROTAC DTAG-13;(2S)-(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)amino)-2-oxoethoxy)phenyl)propyl 1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate, d-TAG-13;(1R)-3-(3,4-dimethoxyphenyl)-1-(2-{[(6-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}hexyl)carbamoyl]methoxy}phenyl)propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate;2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester, (2S)-
- CBNumber:
- CB55582346
- Molecular Formula:
- C57H68N4O15
- Molecular Weight:
- 1049.17
- MDL Number:
- MFCD32670722
- MOL File:
- 2064175-41-1.mol
| Product description | Number | Pack Size | Price |
| dTAG-13 ≥98% (HPLC) | SML2601 | 1 mg | $177 |
| dTAG-13 ≥98% (HPLC) | SML2601 | 5 mg | $663.1 |
| dTAG-13 | D710020 | 10mg | $2575 |
dTAG-13 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2601 | dTAG-13 ≥98% (HPLC) | 2064175-41-1 | 1 mg | $177 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML2601 | dTAG-13 ≥98% (HPLC) | 2064175-41-1 | 5 mg | $663.1 | 2025-07-31 | Buy |
| TRC | D710020 | dTAG-13 | 2064175-41-1 | 10mg | $2575 | 2021-12-16 | Buy |
dTAG-13 Chemical Properties,Uses,Production
Uses
dTAG-13 is a degradation tag which was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.
Biological Activity
dTAG-13 is a degradation tag (dTAG) system heterobifunctional degrader composed of an E3 ubiquitin ligase cereblon (CRBN)-binding thalidomide moiety and an FKBP12(F36V) mutant-specific ligand AP1867 void of affinity for endogenous (wild-type) FKBP12, allowing selective degradation of target proteins of interest when expressed as an FKBP12(F36V) in-frame fusion (by transgene expression or locus-specific knock-in) by bridging them with CRBN for ubiquitination. dTAG-13 is shown to potently degrade FKBP12F36V-MELK(sg3R) in MDA-MB-468 cells (100 nM for 4 hrs) as well as ENL-FKBP12F36V-HA, but not endogenous ENL, in MV4;1 cells (500 nM for 0.5-1 hrs).
in vivo
Following bone marrow engraftment of MV4;11 cells expressing luc-FKBP12F36V in mice, the bioluminescent signal after vehicle or dTAG-13 administration is monitored. A significant, rapid, and durable effect on bioluminescent signal is observed four hours after dTAG-13 administration, indicating effective degradation of luc-FKBP12F36V. Twenty-eight hours following the final treatment, the recovery of cellular bioluminescence to levels comparable between vehicle and dTAG-13 treatment groups is observed[1].
IC 50
Cereblon; FKBP12(F36V)
storage
Store at -20°C
dTAG-13 Preparation Products And Raw materials
Raw materials
Preparation Products
dTAG-13 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3506 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7780 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1608 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | YN_research@163.com | China | 3003 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 19301387927 19301387927 | yh-wang@univ-bio.com | China | 25006 | 58 |
View Lastest Price from dTAG-13 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-16 | FKBP12 PROTAC dTAG-13
2064175-41-1
|
US $163.00 / mg | 97.31% | 10g | TargetMol Chemicals Inc. |
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- FKBP12 PROTAC dTAG-13
2064175-41-1
- US $163.00 / mg
- 97.31%
- TargetMol Chemicals Inc.
