IRAK 2 antibody
- CAS No.
- Chemical Name:
- IRAK 2 antibody
- Synonyms
- IRAK 2 antibody
- CBNumber:
- CB55648345
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
IRAK 2 antibody price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb622646 | IRAK2 Antibody | 50μl | $400 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb622646 | IRAK2 Antibody | 100μl | $540 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb195189 | IRAK2 Antibody | 50μl | $260 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb195189 | IRAK2 Antibody | 100μl | $360 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb10933 | IRAK2 antibody Affinity purified by Protein A | 100μg | $421.6 | 2021-12-16 | Buy |
IRAK 2 antibody Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Interleukin-1 receptor-associated kinase is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members. The binding of IL-1 to IL-1 receptor type I initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs. IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases.Unlike IRAK1 and IRAK4, IRAK2 and IRAK-M do not have significant kinase activity although they can still activate NF-κB when overexpressed. Antisense oligonucleotide depletion of IRAK2 can inhibit IL-1 mediated NF-κB activation.
References
[1] Dinarello, C.A. (1996) Blood 87, 2095-147.
[2] Takaesu, G. et al. (2001) Mol Cell Biol 21, 2475-84.
[3] Janssens, S. and Beyaert, R. (2003) Mol Cell 11, 293-302.
[4] Wesche, H. et al. (1999) J Biol Chem 274, 19403-10.
[5] Muzio, M. et al. (1997) Science 278, 1612-5.
[6] Guo, F. et al. (1999) Inflammation 23, 535-43.
IRAK 2 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
IRAK 2 antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 027-19371278702 18008634902 | 19384116026@163.com | China | 3008 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 58 |
