PIAA
- CAS No.
- 851814-28-3
- Chemical Name:
- PIAA
- Synonyms
- PIAA;TBK1/IKKε-IN-3;3-(3-Phenyl-2,1-benzisoxazol-5-yl)-2-propenoic acid;2-Propenoic acid, 3-(3-phenyl-2,1-benzisoxazol-5-yl)-
- CBNumber:
- CB55867544
- Molecular Formula:
- C16H11NO3
- Molecular Weight:
- 265.26
- MDL Number:
- MFCD06386715
- MOL File:
- 851814-28-3.mol
| Boiling point | 511.9±35.0 °C(Predicted) |
|---|---|
| Density | 1.323±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 2mg/mL, clear (warmed) |
| pka | 4.08±0.50(Predicted) |
| form | powder |
| color | white to beige |
| InChI | 1S/C16H11NO3/c18-15(19)9-7-11-6-8-14-13(10-11)16(20-17-14)12-4-2-1-3-5-12/h1-10H,(H,18,19)/b9-7+ |
| InChIKey | FCMHXGNYHDXIPU-VQHVLOKHSA-N |
| SMILES | n1[o]c(c3c1ccc(c3)\C=C\C(=O)O)c2ccccc2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
PIAA price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2564 | PIAA ≥98% (HPLC) | 851814-28-3 | 5 mg | $69.02 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2564 | PIAA ≥98% (HPLC) | 851814-28-3 | 25 mg | $278.8 | 2026-04-30 | Buy |
| Biosynth | BJB81428 | 3-(3-Phenyl-2,1-benzisoxazol-5-yl)-2-propenoic acid | 851814-28-3 | 5mg | $250 | 2026-06-04 | Buy |
| Biosynth | BJB81428 | 3-(3-Phenyl-2,1-benzisoxazol-5-yl)-2-propenoic acid | 851814-28-3 | 10mg | $308.5 | 2026-06-04 | Buy |
| Biosynth | BJB81428 | 3-(3-Phenyl-2,1-benzisoxazol-5-yl)-2-propenoic acid | 851814-28-3 | 25mg | $578.25 | 2026-06-04 | Buy |
PIAA Chemical Properties, Uses, Production
Definition
ChEBI: 3-(3-phenyl-2,1-benzoxazol-5-yl)-2-propenoic acid is a member of cinnamic acids.
Biological Activity
PIAA is an inhibitor of TANK binding kinase 1 (TBK1) and IKB kinase epsilon (IKKε) th at has been shown to promote regeneration of pancreatic β-cells. PIAA improved function and replication of mammalian β-cells including primary human β-cells and induced β-cell proliferation in streptozotocin-induced diabetic mice resulting in increased pancreas insulin content and improved glycemic control. PIAA exhibited an IC50 value of 400 nM for TBK1 and 1.07 μM for IKKε with minimum toxicity
PIAA Preparation Products And Raw materials
Raw materials
Preparation Products
PIAA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
