Ethanone, 1-?[9-?(6-?amino-?3-?pyridinyl)?-?6,?7-?dichloro-?1,?3,?4,?5-?tetrahydro-?2H-?pyrido[4,?3-?b]?indol-?2-?yl]?-?2-?hydroxy-
![Ethanone, 1-?[9-?(6-?amino-?3-?pyridinyl)?-?6,?7-?dichloro-?1,?3,?4,?5-?tetrahydro-?2H-?pyrido[4,?3-?b]?indol-?2-?yl]?-?2-?hydroxy- Structure](CAS/20210111/GIF/2369751-30-2.gif)
- CAS No.
- 2369751-30-2
- Chemical Name:
- Ethanone, 1-?[9-?(6-?amino-?3-?pyridinyl)?-?6,?7-?dichloro-?1,?3,?4,?5-?tetrahydro-?2H-?pyrido[4,?3-?b]?indol-?2-?yl]?-?2-?hydroxy-
- Synonyms
- G150, 10 mM in DMSO;Ethanone, 1-[9-(6-amino-3-pyridinyl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy-;1-(9-(6-Aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one;human myeloid cell,macrophage,G 150,dsDNA,cGAS,THP1,G150,Cyclic GMP-AMP Synthase,Inhibitor,G-150,anti-inflammatory,high-throughput screening,inhibit
- CBNumber:
- CB55965493
- Molecular Formula:
- C18H16Cl2N4O2
- Molecular Weight:
- 391.25
- MDL Number:
- MFCD32067964
- MOL File:
- 2369751-30-2.mol
| Product description | Number | Pack Size | Price |
| G150 ≥98% (HPLC) | SML3698 | 5mg | $154.85 |
| G150 ≥98% (HPLC) | SML3698 | 25mg | $647 |
| G150 98.20% | CS-0095946 | 50mg | $1650 |
| G150 98.20% | CS-0095946 | 100mg | $2250 |
| G150 98.20% | CS-0095946 | 5mg | $350 |
Ethanone, 1-?[9-?(6-?amino-?3-?pyridinyl)?-?6,?7-?dichloro-?1,?3,?4,?5-?tetrahydro-?2H-?pyrido[4,?3-?b]?indol-?2-?yl]?-?2-?hydroxy- Properties
| Boiling point | 694.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.545±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 13.47±0.10(Predicted) |
| color | White to off-white |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
Ethanone, 1-?[9-?(6-?amino-?3-?pyridinyl)?-?6,?7-?dichloro-?1,?3,?4,?5-?tetrahydro-?2H-?pyrido[4,?3-?b]?indol-?2-?yl]?-?2-?hydroxy- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3698 | G150 ≥98% (HPLC) | 2369751-30-2 | 5mg | $154.85 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML3698 | G150 ≥98% (HPLC) | 2369751-30-2 | 25mg | $647 | 2025-07-31 | Buy |
| ChemScene | CS-0095946 | G150 98.20% | 2369751-30-2 | 50mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0095946 | G150 98.20% | 2369751-30-2 | 100mg | $2250 | 2021-12-16 | Buy |
| ChemScene | CS-0095946 | G150 98.20% | 2369751-30-2 | 5mg | $350 | 2021-12-16 | Buy |
Ethanone, 1-?[9-?(6-?amino-?3-?pyridinyl)?-?6,?7-?dichloro-?1,?3,?4,?5-?tetrahydro-?2H-?pyrido[4,?3-?b]?indol-?2-?yl]?-?2-?hydroxy- Chemical Properties,Uses,Production
Uses
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory[1].
Biological Activity
G150 is a substrate site-targeting, potent and selective human cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 10.2 nM; 100 nM h-cGAS, 0.1 mM ATP & GTP, 25 nM 100-bp dsDNA) with no murine cGAS potency (IC50 >25 μM) and low cytotoxicity (THP1 LD50 = 53 μM). G150 selectively inhibits dsDNA-induced IFNB1/CXCL10 transcription in THP1 (IC50 = 1.96/7.57 μM) & primary human macrophages (IC50 = 0.62/0.87 μM) without affecting adenylyl cyclase activity, direct STING activation by cGAMP, or immune responses induced by hpRNA (RIG-I pathway), poly(I:C) (OAS/RNase L pathway), LPS (TLR4 pathway).
References
[1] Lama L, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21;10(1):2261. DOI:10.1038/s41467-019-08620-4
Ethanone, 1-?[9-?(6-?amino-?3-?pyridinyl)?-?6,?7-?dichloro-?1,?3,?4,?5-?tetrahydro-?2H-?pyrido[4,?3-?b]?indol-?2-?yl]?-?2-?hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
Ethanone, 1-?[9-?(6-?amino-?3-?pyridinyl)?-?6,?7-?dichloro-?1,?3,?4,?5-?tetrahydro-?2H-?pyrido[4,?3-?b]?indol-?2-?yl]?-?2-?hydroxy- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4801 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 985 | 55 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2496 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
