ChemicalBook >> CAS DataBase List >>4-Chloro-1H-pyrazolo[3,4-d]pyrimidine

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine structure

CAS No.: 5399-92-8

Chemical Name:: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine

Synonyms: NSC 4937;oro-1H-pyrazoL;AKOS BBS-00002106;o[3,4-d]pyrimidine;IFLAB-BB F0909-0060;4-chloro-1H-pyrazolo[3;Ibrutinib Impurity 115;4-Chloropyrazolo[3,4-d]pyrimidine;4-CHLORO-1H-PYRAZOLO3,4-DPYRIMIDINE;-chloro-1H-pyrazolo[3,4-d]pyrimidine

CBNumber:: CB5668331

Molecular Formula:: C5H3ClN4

Molecular Weight:: 154.56

MDL Number:: MFCD03030404

MOL File:: 5399-92-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:19:11

Product description	Number	Pack Size	Price
4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	267775	10g	$460
4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	267775	25g	$708
4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	267775	50g	$984
4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	267775	100g	$1380
4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	267775	250g	$2229
More product size

Request For Quotation

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Properties

Melting point	>350C
Boiling point	224.6±50.0 °C(Predicted)
Density	1.84±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	10.16±0.20(Predicted)
color	Yellow to Orange
CAS DataBase Reference	5399-92-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H315-H302-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
Hazard Note	Harmful
HazardClass	IRRITANT
HS Code	29335990

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	267775	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	5399-92-8	10g	$460	2026-06-03	Buy
Usbiological	267775	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	5399-92-8	25g	$708	2026-06-03	Buy
Usbiological	267775	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	5399-92-8	50g	$984	2026-06-03	Buy
Usbiological	267775	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	5399-92-8	100g	$1380	2026-06-03	Buy
Usbiological	267775	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Asreported	5399-92-8	250g	$2229	2026-06-03	Buy

Product number	Packaging	Price	Buy
267775	10g	$460	Buy
267775	25g	$708	Buy
267775	50g	$984	Buy
267775	100g	$1380	Buy
267775	250g	$2229	Buy

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

Has a SK channel blocker effect.

Synthesis

5305-40-8

5399-92-8

Synthesis of compound 4.1. Hydrazine hydrate (11.5 mL, 23.7 mmol) was slowly added dropwise to a 1,4-dioxane solution (600 mL) containing 4,6-dichloro-5-pyrimidinecarboxaldehyde (40.0 g, 22.6 mmol) and triethylamine (30 mL, 22 mmol) under the cooling of an ice bath, and the temperature of the reaction was controlled to be no more than 20°C. The reaction temperature was controlled to be no higher than 20°C. After dropwise addition, the reaction mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the precipitate was collected by filtration. The filtrate was concentrated under reduced pressure to give compound 4.1 (29 g, 83% yield) in the form of a light yellow solid. The product was characterized by 1H NMR (400.13 MHz, DMSO-d6) and mass spectrometry: 1H NMR δ 14.52 (br.s, 1H), 8.83 (s, 1H), 8.45 (s, 1H); MS m/z 155 [M + 1]+.

References

[1] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 18
[2] Patent: WO2008/153947, 2008, A2. Location in patent: Page/Page column 42; 63-64
[3] Molecules, 2017, vol. 22, # 4,
[4] Patent: CN106496232, 2017, A. Location in patent: Paragraph 0049; 0050; 0051; 0052
[5] Patent: CN107383014, 2017, A. Location in patent: Paragraph 0075; 0076; 0077; 0078

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2,5-dihydro- (9CI) Allopurinol Hydrazine hydrate 4,6-Dichloro-5-pyrimidinecarbaldehyde Triethylamine

1,4-Dioxane HYDRAZINE

1of2

Preparation Products

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine 4-(1H-Pyrazolo[3,4-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-methyl- (9CI) tert-butyl 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Suppliers

Global( 255)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shanghai Arbor Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Nanjing Baifuli Technology Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine 5399-92-8				10g	TargetMol Chemicals Inc.
2025-09-25	6-Chloropurine 5399-92-8	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2025-04-04	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine 5399-92-8		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
5399-92-8
TargetMol Chemicals Inc.

6-Chloropurine
5399-92-8
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
5399-92-8
98%
Henan Aochuang Chemical Co.,Ltd.

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Spectrum

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine(5399-92-8)¹HNMR

5399-92-8(4-Chloro-1H-pyrazolo[3,4-d]pyrimidine)Related Search:

Trazodone Zolpidem tartrate Sodium cloxacillin monohydrate Cloxacillin Chlorzoxazone

Pyrimidine Zolpidem 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE Difluorochloromethane ethyl 5,7-dichloro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylate

7-CHLORO-5-METHYLPYRAZOLO[1,5-A]PYRIMIDINE 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(4-METHOXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE

4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(2,4-DIMETHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(3,5-DI-O-TOLUOYL-BETA-D-2-DEOXYRIBOFURANOSYL)PYRAZOLO[3,4-D]PYRIMIDINE

1of4

IFLAB-BB F0909-0060 4-CHLORO-1H-PYRAZOLO3,4-DPYRIMIDINE AKOS BBS-00002106 1H-Pyrazolo[3,4-d]pyrimidine, 4-chloro- 4-Chloropyrazolo[3,4-d]pyrimidine NSC 4937 4-chloro-1H-pyrazolo[3 4-Chlor-1(2)Hpyrazolo[3,4-d]pyriMidine 4-chloro-1(2)H-pyrazolo[3,4-d]pyriMidine 4-Chloro-1H-pyrazolo[3,4-d]pyriMidine, 95+% 4-chloro-1H-pyrazolo[4,3-e]pyrimidine oro-1H-pyrazoL o[3,4-d]pyrimidine Ibrutinib Impurity 115 4-Chloro-5H-pyrazolo[3,4-d]pyrimidine -chloro-1H-pyrazolo[3,4-d]pyrimidine 5399-92-8 Heterocycle-Pyrimidine series Halides Bases & Related Reagents Heterocycles Inhibitors Nucleotides Fused Ring Systems