Carbobenzoxyhydrazide
- CAS No.
- 5331-43-1
- Chemical Name:
- Carbobenzoxyhydrazide
- Synonyms
- Benzyl hydrazinecarboxylate;BENZYL CARBAZATE;Benzyl carbazate 97%;Phenylmethyl N-aminocarbamate;BzNN;Z-NHNH2;NSC 2287;Z-HYDRAZIDE;Z-HYDRAZINE;Cbz-Hydrazine
- CBNumber:
- CB5679119
- Molecular Formula:
- C8H10N2O2
- Molecular Weight:
- 166.18
- MDL Number:
- MFCD00041890
- MOL File:
- 5331-43-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Benzyl carbazate 97% | 499781 | 5g | $39.8 |
| Benzyl carbazate 97% | 499781 | 25g | $167 |
| Benzyl Carbazate >98.0%(T) | C1564 | 5g | $20 |
| Benzyl Carbazate >98.0%(T) | C1564 | 25g | $49 |
| N-alpha-Z-hydrazide | 279895 | 25g | $340 |
| More product size | |||
| Melting point | 65-68 °C (lit.) |
|---|---|
| Boiling point | 294.38°C (rough estimate) |
| Density | 1.2265 (rough estimate) |
| refractive index | 1.6180 (estimate) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| pka | 10.56±0.20(Predicted) |
| form | Solid |
| color | Beige |
| Water Solubility | Soluble in water (slightly), methanol and DMSO. |
| BRN | 1952982 |
| Major Application | peptide synthesis |
| InChI | 1S/C8H10N2O2/c9-10-8(11)12-6-7-4-2-1-3-5-7/h1-5H,6,9H2,(H,10,11) |
| InChIKey | RXUBZLMIGSAPEJ-UHFFFAOYSA-N |
| SMILES | NNC(=O)OCc1ccccc1 |
| CAS DataBase Reference | 5331-43-1(CAS DataBase Reference) |
| FDA UNII | H7GM2H55TC |
| NIST Chemistry Reference | Hydrazinecarboxylic acid, phenylmethyl ester(5331-43-1) |
| EPA Substance Registry System | Hydrazinecarboxylic acid, phenylmethyl ester (5331-43-1) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 41 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MV1724950 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29280000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 | |||||||||
| NFPA 704 |
|
Carbobenzoxyhydrazide price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 499781 | Benzyl carbazate 97% | 5331-43-1 | 5g | $39.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | 499781 | Benzyl carbazate 97% | 5331-43-1 | 25g | $167 | 2025-07-31 | Buy |
| TCI Chemical | C1564 | Benzyl Carbazate >98.0%(T) | 5331-43-1 | 5g | $20 | 2025-07-31 | Buy |
| TCI Chemical | C1564 | Benzyl Carbazate >98.0%(T) | 5331-43-1 | 25g | $49 | 2025-07-31 | Buy |
| Usbiological | 279895 | N-alpha-Z-hydrazide | 5331-43-1 | 25g | $340 | 2021-12-16 | Buy |
Carbobenzoxyhydrazide Chemical Properties,Uses,Production
Chemical Properties
LIGHT BEIGE SHINY FLAKES
Uses
Benzyl Carbazate has been shown to prevent the occurrence of oligonucleosome-sized DNA fragmentation in the cell-free system.
Uses
Benzyl carbazate is used as a reagent for preparation of benzyloxycarbonyl (Z, Cbz) hydrazides of carboxylic acids, particularly N-protected amino acids. Subsequent hydrogenolysis gives the hydrazide which can be converted to the azide for coupling with a further amino acid residue by the azide method. It is also used in the preparation of simple acyl or sulfonyl hydrazides avoiding diacylation.
Synthesis
501-53-1
5331-43-1
1. General procedure for the synthesis of benzyl hydrazinecarboxylate: In a three-necked reaction flask equipped with temperature control, hydrazine hydrate (2.0 mol), potassium carbonate (2.0 mol), and 50 mL of tetrahydrofuran are added sequentially. After cooling the reaction system to -20°C, benzyl chloroformate (2.0 mol) was slowly added. After completion of the reaction, stirring was continued for 2 h. The potassium carbonate was subsequently removed by filtration and washed with water. The organic phase was concentrated to give the crude product of benzyl hydrazinecarboxylate (95.0% yield, 96.0% purity as determined by high performance gas chromatography (GC)). 2. Purification of the crude product of benzyl hydrazinecarboxylate: In another three-necked reaction flask, add the crude product of benzyl hydrazinecarboxylate (40.0 g, purity 96.0%, determined by high performance gas chromatography (GC)) and 400 mL of dichloromethane. 80 mL of 30% hydrochloric acid was added dropwise to the reaction system and solid precipitation was observed. 150 mL of water was added to dissolve some of the solids. The organic layer was separated and retained. Add 80 mL of ammonia dropwise to the aqueous layer and adjust the pH to alkaline. The aqueous layer was extracted three times with 250 mL of dichloromethane. The organic phases were combined and concentrated to give purified benzyl hydrazinecarboxylate (36.0 g, 99.5% purity, 90.0% yield as determined by high performance gas chromatography (GC)).
References
[1] Patent: CN103819366, 2016, B. Location in patent: Paragraph 0024-0027
[2] Canadian Journal of Chemistry, 2000, vol. 78, # 7, p. 942 - 949
[3] Chemische Berichte, 1959, vol. 92, p. 1478
[4] Chemische Berichte, 1965, vol. 98, p. 797 - 802
Carbobenzoxyhydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8752 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Tianjin Zhongxin Chemtech Co., Ltd. | 86-22-66880623 +8618622897568 | sales@tjzxchem.com | China | 572 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29830 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
View Lastest Price from Carbobenzoxyhydrazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-06 | Carbobenzoxyhydrazide
5331-43-1
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-03-06 | Carbobenzoxyhydrazide
5331-43-1
|
US $0.00 / Kg/Drum | 1KG | 98%min HPLC | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-05-23 | Carbobenzoxyhydrazide
5331-43-1
|
US $99.00-45.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- Carbobenzoxyhydrazide
5331-43-1
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Carbobenzoxyhydrazide
5331-43-1
- US $0.00 / Kg/Drum
- 98%min HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Carbobenzoxyhydrazide
5331-43-1
- US $99.00-45.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
