AG 1295
- CAS No.
- 71897-07-9
- Chemical Name:
- AG 1295
- Synonyms
- AG 1295;NSC 380341;AG 1295 USP/EP/BP;TYRPHOSTIN AG 1295;TYROPHOSTIN AG1295;AG-1295 (NSC 380341;AG 1295, 10 mM in DMSO;TYRPHOSTIN AG 1295, 99+%;AG 1295 PLATELET-DERIVED GROW;6,7-DIMETHYL-2-PHENYLQUINOXALINE
- CBNumber:
- CB5683675
- Molecular Formula:
- C16H14N2
- Molecular Weight:
- 234.3
- MDL Number:
- MFCD00270912
- MOL File:
- 71897-07-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| AG 1295 | 658550 | 5mg | $149 |
| 6,7-DIMETHYL-2-PHENYL-QUINOXALINE AldrichCPR | R365327 | 25MG | $28.6 |
| AG-1295 ≥98% | 14529 | 1mg | $36 |
| AG-1295 ≥98% | 14529 | 5mg | $110 |
| AG-1295 ≥98% | 14529 | 10mg | $203 |
| More product size | |||
| Melting point | 121 °C |
|---|---|
| Boiling point | 398.3±37.0 °C(Predicted) |
| Density | 1.127±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | 1.29±0.30(Predicted) |
| form | White solid |
| color | Yellow |
| InChI | 1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3 |
| InChIKey | FQNCLVJEQCJWSU-UHFFFAOYSA-N |
| SMILES | n1c2c(ncc1c3ccccc3)cc(c(c2)C)C |
| FDA UNII | FWH2FYS649 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
AG 1295 price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 658550 | AG 1295 | 71897-07-9 | 5mg | $149 | 2026-04-30 | Buy |
| Sigma-Aldrich | R365327 | 6,7-DIMETHYL-2-PHENYL-QUINOXALINE AldrichCPR | 71897-07-9 | 25MG | $28.6 | 2023-06-20 | Buy |
| Cayman Chemical | 14529 | AG-1295 ≥98% | 71897-07-9 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 14529 | AG-1295 ≥98% | 71897-07-9 | 5mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 14529 | AG-1295 ≥98% | 71897-07-9 | 10mg | $203 | 2026-04-30 | Buy |
AG 1295 Chemical Properties,Uses,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-
Uses
AG-1295 is a protein tyrosine kinase inhibitor. Antiproliferative agent used in the treatment of atherosclerosis, pulmonary fibrosis, and gliomas.
Definition
ChEBI: 6,7-dimethyl-2-phenylquinoxaline is a quinoxaline derivative. It has a role as a geroprotector.
in vitro
the previous study investigated the effect of pdgf receptor-beta (pdgfr-β) inhibition by ag-1295 on the osteogenic differentiation of the mouse pre-osteoblastic cell line mc3t3-e1. results showed that ag-1295 could significantly increase the alkaline phosphatase (alp) activity and enhance the formation of mineralized nodules dose-dependently. moreover, the treatment with ag-1295 led to the up-regulated mrna expression of the osteogenic marker genes collagen type i, runt-related transcription factor 2, osterix, tissue-nonspecific alkaline phosphatase, as well as osteocalcin. consistent with its effect on osteoblast differentiation, ag-1295 was also able to significantly suppress the phosphorylation of erk1/2 in mc3t3-e1 cells [1].
in vivo
a previous animal study was designed to evaluated the possible effects of ag1295 on the development of interstitial fibrosis in rats with unilateral ureteral obstruction, monitored by ed-a+ fibronectin expression, the number of macrophages. results showed that the i.p.treatment with ag1295 at 12 mg/kg could significantly reduce interstitial fibrosis as verified by a smaller sirius-red stained area and also by a reduced number of macrophages, and by the ed-a+ fibronectin deposition and the number of cells positive for α-smooth muscle actin [2].
IC 50
0.3-1 μm for pdgf receptor kinase in vitro and in swiss 3t3 cells
References
[1] zhang yy, cui yz, luan j, zhou xy, zhang gl, han jx. platelet-derived growth factor receptor kinase inhibitor ag-1295 promotes osteoblast differentiation in mc3t3-e1 cells via the erk pathway. biosci trends. 2012 jun;6(3):130-5.
[2] ludewig d, kosmehl h, sommer m, bhmer fd, stein g. pdgf receptor kinase blocker ag1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction. cell tissue res. 2000 jan;299(1):97-103.
AG 1295 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39866 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
View Lastest Price from AG 1295 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | AG 1295
71897-07-9
|
$47.00-146.00 | 99.93% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | AG 1295
71897-07-9
|
$47.00-146.00 | 99.93% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | AG 1295
71897-07-9
|
$1.00 | 1KG | 98-100% | 1000kg | Career Henan Chemical Co |
