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Formoterol fumarate

Formoterol fumarate structure

CAS No.: 43229-80-7

Chemical Name:: Formoterol fumarate

Synonyms: Aformoterol;FORMOTEROL HEMIFUMARATE;YM 08316;FarMeterol;CGP 25827A;NSC 299587;CGP-25827A-e;Fumarate dihydrate;FORMAMIDE FUMARATE;FORADIL;FORMOTEROL

CBNumber:: CB5689602

Molecular Formula:: C42H52N4O12

Molecular Weight:: 804.88

MDL Number:: MFCD03093863

MOL File:: 43229-80-7.mol

MSDS File:: SDS

Last updated:2026-01-13 11:22:27

Product description	Number	Pack Size	Price
Formoterol for system suitability European Pharmacopoeia (EP) Reference Standard	Y0002298	10 mg	$180
Formoterol for impurity I identification European Pharmacopoeia (EP) Reference Standard	Y0000339	10 mg	$167
Formoterol for impurity I identification European Pharmacopoeia (EP) Reference Standard	Y0000339	y0000339	$153
Formoterol fumarate for system suitability European Pharmacopoeia (EP) Reference Standard	Y0000340	y0000340	$218
Formoterol (hemifumarate) ≥99%	15584	10mg	$88
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Formoterol fumarate Properties

Melting point	138-140°C
storage temp.	Room temperature
solubility	Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile.
pka	pKa1 7.9; pKa2 9.2(at 25℃)
form	Solid
color	White to off-white
λmax	284nm(lit.)
Merck	14,4245
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Major Application	pharmaceutical
InChIKey	OBRNDARFFFHCGE-WXXKFALUSA-N
SMILES	N(C(Cc4ccc(cc4)OC)C)CC(O)c3cc(c(cc3)O)NC=O.N(C(Cc2ccc(cc2)OC)C)CC(O)c1cc(c(cc1)O)NC=O.OC(=O)\C=C\C(=O)O
FDA UNII	P3T5QA5J9N
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H300-H361d-H370-H373-H412
Precautionary statements	P201-P202-P260-P264-P273-P301+P310
RIDADR	3249
WGK Germany	WGK 3
RTECS	LQ2988000
HazardClass	6.1(b)
PackingGroup	II
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Inhalation Aquatic Chronic 3 Repr. 2 STOT RE 2 STOT SE 1
Toxicity	LD50 in male, female, rats, mice (mg/kg): 3130, 5580, 6700, 8310 orally; 98, 100, 72, 71 i.v.; 1000, 1100, 640, 670 s.c.; 170, 210, 240, 210 i.p. (Yoshida)

Formoterol fumarate price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0002298	Formoterol for system suitability European Pharmacopoeia (EP) Reference Standard	43229-80-7	10 mg	$180	2026-03-19	Buy
Sigma-Aldrich	Y0000339	Formoterol for impurity I identification European Pharmacopoeia (EP) Reference Standard	43229-80-7	10 mg	$167	2026-03-19	Buy
Sigma-Aldrich	Y0000339	Formoterol for impurity I identification European Pharmacopoeia (EP) Reference Standard	43229-80-7	y0000339	$153	2024-03-01	Buy
Sigma-Aldrich	Y0000340	Formoterol fumarate for system suitability European Pharmacopoeia (EP) Reference Standard	43229-80-7	y0000340	$218	2023-01-07	Buy
Cayman Chemical	15584	Formoterol (hemifumarate) ≥99%	43229-80-7	10mg	$88	2021-12-16	Buy

Product number	Packaging	Price	Buy
Y0002298	10 mg	$180	Buy
Y0000339	10 mg	$167	Buy
Y0000339	y0000339	$153	Buy
Y0000340	y0000340	$218	Buy
15584	10mg	$88	Buy

Formoterol fumarate Chemical Properties,Uses,Production

Description

Formoterol fumarate is a β2-selective adrenergic agonist useful in the treatment of bronchial asthma. It s potency and duration of action a r e reported to exceed those of salbutamol, as is its ability to inhibit allergic and non-allergic histamine release.

Chemical Properties

Crystalline Solid

Originator

Yarnanouchi (Japan)

Uses

long-acting β 2-agonist, anti-asthmatic

Uses

Formoterol fumarate is a potent β2-AR agonist.

Uses

A selective 2-adrenergic receptor agonist. Used as an antiasthmatic

Uses

antiasthmatic;2-agonist

Definition

ChEBI: (S,S)-formoterol fumarate is a fumarate salt prepared from (S,S)-formoterol by reaction of one molecule of fumaric acid for every two molecules of (S,S)-formoterol. It contains a (S,S)-formoterol(1+). It is an enantiomer of an arformoterol fumarate.

brand name

Foradil (Novartis);ATOCK.

Mechanism of action

This is believed to result from formoterol's greater water solubility, allowing it to get to the receptor sites faster, whereas its moderate lipophilicity keeps it in the lungs longer. It is indicated for the long-term maintenance treatment of asthma and for patients with symptoms of nocturnal asthma who require regular treatment with inhaled, short-acting, β2-agonists. It is not indicated for patients whose asthma can be managed by occasional use of inhaled, short-acting, β2-agonists. Formoterol is available only as a powder in a capsule for administration via the aerosolizer. Patients should be cautioned not to take the capsules orally and to keep them in a safe place to avoid accidental oral administration.

Clinical Use

Formoterol has a β-directing N-isopropyl-p-methoxyphenyl group and a unique m-formamide and p-hydroxyphenyl ring, which provides selectivity for β2-receptors. It is resistant to MAO and COMT, making it a long-acting agonist. Formoterol has a more rapid onset as compared to salmeterol while maintaining the same long duration of action.

storage

Store at RT

References

[1] ANDERSON G P. Formoterol: Pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β2-adrenoceptor agonist bronchodilator[J]. Life sciences, 1993, 52 26: Pages 2145-2160. DOI:10.1016/0024-3205(93)90729-m
[2] XIN TENG . Structure–activity relationship study of novel necroptosis inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2005, 15 22: Pages 5039-5044. DOI:10.1016/j.bmcl.2005.07.077
[3] TORU NOGUCHI . Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation[J]. Allergology International, 2015, 64: Pages S46-S53. DOI:10.1016/j.alit.2015.05.009
[4] SÍLVIA BUSQUETS. Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting.[J]. Cancer research, 2004, 64 18: 6725-6731. DOI:10.1158/0008-5472.can-04-0425
[5] EOIN O’NEILL. Pharmacological targeting of β2-adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson’s disease[J]. British Journal of Pharmacology, 2019, 177 2: 282-297. DOI:10.1111/bph.14862

Formoterol fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

Formoterol fumarate Suppliers

Global( 387)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
Longyan Tianhua Biological Technology Co., Ltd	0086 18039857276 18039857276		CHINA	2783	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Qiuxian Baitai New Material Co., LTD	+8618330912755	sale2@hbyalin.com	China	1658	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2251	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hubei Ipure Biology Co., Ltd	58
Longyan Tianhua Biological Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Qiuxian Baitai New Material Co., LTD	58
Xi'an MC Biotech, Co., Ltd.	58

View Lastest Price from Formoterol fumarate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-20	Formoterol fumarate 43229-80-7			0.99		RongNa Biotechnology Co.,Ltd
2025-11-18	Formoterol fumarate USP/EP/BP 43229-80-7	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2023-06-26	Formoterol Hemifumarate 43229-80-7	US $200.00 / kg	1kg	99%	1000kg/Month	Hebei Mingeng Biotechnology Co., Ltd

Formoterol fumarate
43229-80-7
0.99
RongNa Biotechnology Co.,Ltd

Formoterol fumarate USP/EP/BP
43229-80-7
US $1.10 / g
99.9%
Dideu Industries Group Limited

Formoterol Hemifumarate
43229-80-7
US $200.00 / kg
99%
Hebei Mingeng Biotechnology Co., Ltd

Formoterol fumarate Spectrum

Formoterol fumarate(43229-80-7)¹HNMR

43229-80-7(Formoterol fumarate)Related Search:

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1,5-Diphenylcarbazide Formoterol fumarate dihydrate Formoterol (N,O-DIBENZYLATED) FORMOTEROL FUMARATE, 98% ( FOR FORMOTEROL FUMARATE ),N,O-DIBENZYLATED FORMOTEROL FUMARATE Formamide

FUMARATE FORMOTEROL FUMARATE FOR SYSTEM SUITABILITY FORMOTEROL FUMARATE HYDRATE

1of4

formamide,n-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amin o)ethyl)phenyl)-,(e)-2-butenedioate(2:1)(salt),dihydrate (+/-)-(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL] FORMAMIDE HEMIFUMARATE (R*,R*)-(+)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-PHENYL]FORMAMIDE FUMARATE (R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL]FORMAMIDE FUMARATE Formoterol fumarate JP13 Formoterol fumarate 50 gram FORMATEROL FUMATATE FORMOTEROL FUMARATE, FOR SYSTEM SUITABILITY EP STANDARD FORMOTEROL FUMARATE, FOR IMPURITY D IDENTIFICATION EP STANDARD FORMOTEROL FUMARATE, EP STANDARD rel-N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide Fumarate Dihydrate Formoterol & Formoterol Fumarate FarMeterol ForMaterol FuMarate (R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2 ForMoterol FuMarate EP/USP ForMoterol FuMarate Dihydrate API N-(2-hydroxy-5-((S)-1-hydroxy-2-((S)-1-(4-methoxyphenyl)propan-2-ylamino)ethyl)phenyl)formamide hemifumaric acid Formoterol fumarate N-[2-Hydroxy-5-[[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (E)-2-butenedioate Aformoterol CGP 25827A Eformoterol fumarate Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel-, (2E)-2-butenedioate (2:1) (salt) Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(+-)-, (E)-2-butenedioate (2:1) (salt) Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-, (E)-2-butenedioate (2:1) (salt) NSC 299587 YM 08316 FORMOTEROL FUMARATE FORMOTEROL HEMIFUMARATE n-[2-hydroxy-5-[[(1rs)-1-hydroxy-2-[[(1rs)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (e)-2-butenedioate BD-40A, Atock, Foradil, Oxeze Formoterol dihydrate fumarate Formoterol monohydrate hemifumarate salt, (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate (2:1) salt CGP-25827A-e Fumarate dihydrate FORMAMIDE FUMARATE rel-N-(2-hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide hemifumarate FORADIL;FORMOTEROL N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-(4-methoxyphenyl)-1-methylethyl]-amino]ethyl]phenyl]formamide Formoterol for impurity I identification CRS Formoterol fumarate for system suitability CRS Eformoterol Hemifumarate Formoterol fumarate USP/EP/BP Formoterol Fumarate Anhydrous Formoterol D6 fumarateQ: What is Formoterol D6 fumarate Q: What is the CAS Number of Formoterol D6 fumarate Q: What is the storage condition of Formoterol D6 fumarate Q: What are the applications of Formoterol D6 fumarate Formoterol for impurity I identification (Y0000339) Formoterol FumarateQ: What is Formoterol Fumarate Q: What is the CAS Number of Formoterol Fumarate Q: What is the storage condition of Formoterol Fumarate Q: What are the applications of Formoterol Fumarate Formoterol fumerate dihydrate Formoterol Furoate 43229-80-7 Formoterol Fumarate N-(2-hydroxy-5-((S)-1-hydroxy-2-(((S)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide fumarate Formoterol Fumarate Base Sialyllactose Impurity 21 N-(2-hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide, fumarate (2:1) Formoterol hemifumarate, beta2 adrenoceptor agonist Formoterol fumarate, 10 mM in DMSO