Dansyl chloride
- CAS No.
- 605-65-2
- Chemical Name:
- Dansyl chloride
- Synonyms
- DNS;dansyl;DNSCL;5-DIMETHYLAMINO-1-NAPHTHALENESULFONYL CHLORIDE;SKL100;AI301174;AI3 01174;AI3-01174;DNS chloride;ansylchloride
- CBNumber:
- CB5696240
- Molecular Formula:
- C12H12ClNO2S
- Molecular Weight:
- 269.75
- MDL Number:
- MFCD00003985
- MOL File:
- 605-65-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 72-74 °C(lit.) |
|---|---|
| Boiling point | 371.3±22.0 °C(Predicted) |
| Density | 1.1702 (rough estimate) |
| refractive index | 1.5630 (estimate) |
| storage temp. | 2-8°C |
| solubility | acetone: 50 mg/mL |
| form | powder and chunks |
| pka | 2.38±0.40(Predicted) |
| color | yellow to orange |
| Appearance | Yellow solid |
| Water Solubility | Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water. |
| Sensitive | Moisture Sensitive |
| Merck | 14,2814 |
| BRN | 2217205 |
| Stability | Hygroscopic, Moisture Sensitive |
| InChI | 1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3 |
| InChIKey | XPDXVDYUQZHFPV-UHFFFAOYSA-N |
| SMILES | CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O |
| CAS DataBase Reference | 605-65-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | QMU9166TJ4 |
| EPA Substance Registry System | 1-Naphthalenesulfonyl chloride, 5-(dimethylamino)- (605-65-2) |
| UNSPSC Code | 41116105 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45-3 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QK3688000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214980 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Met. Corr. 1 Skin Corr. 1B |
|||||||||
| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Dansyl chloride price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 39220 | Dansyl chloride BioReagent, suitable for fluorescence, ≥99.0% (HPLC) | 605-65-2 | 1g | $132 | 2026-04-30 | Buy |
| Sigma-Aldrich | 39220 | Dansyl chloride BioReagent, suitable for fluorescence, ≥99.0% (HPLC) | 605-65-2 | 5G | $535 | 2026-04-30 | Buy |
| Sigma-Aldrich | 39220 | Dansyl chloride BioReagent, suitable for fluorescence, ≥99.0% (HPLC) | 605-65-2 | 50g | $2730 | 2026-04-30 | Buy |
| Sigma-Aldrich | 03641 | Dansyl chloride for HPLC derivatization, ≥99.0% (HPLC) | 605-65-2 | 100mg | $52.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 311155 | Dansyl Chloride - CAS 605-65-2 - Calbiochem Reagent used for fluorescent labeling of proteins, N-terminal amino acids, and amines. | 605-65-2 | 1G | $85.6 | 2026-04-30 | Buy |
Dansyl chloride Chemical Properties, Uses, Production
Uses
Dansyl chloride or 5-Dimethylaminonaphthalene-1-sulfonyl chloride (CAS 605-65-2) is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.
Dansyl chloride is non-fluorescent until it reacts with amines. The resulting Dansyl amides have environmentally sensitive fluorescence quantum yields and emission maxima along with large Stokes shifts. This environment-sensitive fluorescence property has made Dansyl chloride an important tool for biophysical studies.
Description
Dansyl Chloride is used for fluorescent labelling of amines, amino acids and proteins.
Chemical Properties
yellow to orange-yellow crystalline powder
Uses
Reagent for fluorescent labelling of amines, amino acids and proteins.
Uses
A fluorogenic reagent for N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.
Uses
In fluorescent labelling, column chromatography, HPLC.
Uses
Dansyl chloride is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.
Definition
ChEBI: Dansyl chloride is an aminonaphthalene and a sulfonic acid derivative.
General Description
Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids.
Biochem/physiol Actions
Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.
Safety Profile
Poison by intravenous route, When heated to decomposition it emits very toxic fumes of Cland NOx
Dansyl chloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bejing Famous Pharmaceutical Technology Co., Ltd. | 010-80339217; 13331045123 | 2559355526@qq.com | China | 14180 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Chongqing Botao Biotechnology Co., LTD | 15223382610 | danny@chemdad.com | China | 2030 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 17714337195 | sales@tybiochem.com | China | 683 | 58 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9954 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
Related articles
- Application of dansyl chloride
- Dansyl chloride or 5-Dimethylaminonaphthalene-1-sulfonyl chloride (CAS 605-65-2) is a fluorogenic reagent used for protein, N-....
- Dec 23,2019
View Latest Price from Dansyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Dansyl chloride
605-65-2
|
1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-02-02 | Dansyl chloride
605-65-2
|
$1000.00 | 1KG | 98%HPLC | 200tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-02-22 | 5-(Dimethylamino)naphthalene-1-sulfonyl chloride
605-65-2
|
1KG | 98.8% | 100 tons | Honest Joy Holdings Limited |
-
- Dansyl chloride
605-65-2
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- Dansyl chloride
605-65-2
- $1000.00
- 98%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-(Dimethylamino)naphthalene-1-sulfonyl chloride
605-65-2
- $0.00
- 98.8%
- Honest Joy Holdings Limited
