CARVEDILOL-D5
- CAS No.
- 929106-58-1
- Chemical Name:
- CARVEDILOL-D5
- Synonyms
- CARVEDILOL-D5;D5-Carvedilol;Carvedilol-D5 (Standard);Carvedilol-d5 N’-?-D-Glucuronide;1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;Carvedilol-D5Q: What is Carvedilol-D5 Q: What is the CAS Number of Carvedilol-D5 Q: What is the storage condition of Carvedilol-D5 Q: What are the applications of Carvedilol-D5
- CBNumber:
- CB5704859
- Molecular Formula:
- C24H21D5N2O4
- Molecular Weight:
- 411.51
- MDL Number:
- MFCD08063416
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Hazard statements | H401-H411 |
| Precautionary statements | P273-P391-P501 |
CARVEDILOL-D5 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25218 | Carvedilol-d5 ≥99%deuteratedforms(d1-d5) | 929106-58-1 | 500μg | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 25218 | Carvedilol-d5 ≥99%deuteratedforms(d1-d5) | 929106-58-1 | 1mg | $203 | 2026-04-30 | Buy |
| Usbiological | 005808 | Carvedilol-d5 | 1mg | $509 | 2026-06-03 | Buy | |
| ChemScene | CS-0375190 | Carvedilol-d5 | 929106-58-1 | 500??g | $274 | 2026-06-04 | Buy |
| ChemScene | CS-0375190 | Carvedilol-d5 | 929106-58-1 | 1mg | $439 | 2026-06-04 | Buy |
CARVEDILOL-D5 Chemical Properties, Uses, Production
Description
Carvedilol-d5 is intended for use as an internal standard for the quantification of carvedilol by GC- or LC-MS. Carvedilol is a non-selective antagonist of the β-adrenergic receptor (β-AR; Kds = 1.78, 0.4, and 5.01 nM for β1-, β2-, and β3-ARs, respectively). It also binds to α1-, but not α2-, adrenergic receptors (Kis = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the β1-AR agonist isoproterenol in isolated guinea pig atria (Kb = 0.8 nM) and induces relaxation of isolated precontracted guinea pig trachea (Kb = 1.3 nM). It prevents epinephrine-induced premature ventricular beats in a rat model of arrhythmia with an ED50 value of 0.25 mg/kg. Carvedilol also inhibits the contractile response to the α1-AR agonist norepinephrine in isolated rabbit aorta (Kb = 11 nM). It decreases systolic blood pressure and heart rate in rat models of hypertension, including spontaneously hypertensive, renal hypertensive, and deoxycorticosterone acetate-treated rats when administered at doses ranging from 3 to 30 mg/kg. Carvedilol also activates cardioprotective signaling through β-arrestin and ERK1/2 activation. Formulations containing carvedilol have been used in the treatment of congestive heart failure and hypertension.
Chemical Properties
White Solid
Uses
Carvedilol-d5 is the labelled analog of Carvedilol, a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.
Uses
Labeled Carvedilol, intended for use as an internal standard for the quantification of Carvedilol by GC- or LC-mass spectrometry.
References
[1] GRAYNA GROSZEK . Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2[J]. European Journal of Medicinal Chemistry, 2009, 44 12: Pages 5103-5111. DOI: 10.1016/j.ejmech.2009.07.012
[2] A J NICHOLS. In vitro pharmacologic profile of the novel beta-adrenoceptor antagonist and vasodilator, carvedilol.[J]. Pharmacology, 1989, 39 5: 327-336. DOI: 10.1159/000138616
[3] M TANAKA. Studies on the antihypertensive properties of carvedilol, a compound with beta-blocking and vasodilating effects.[J]. Journal of Cardiovascular Pharmacology, 1987, 10 Suppl 11: S52-7.
[4] JAMES W WISLER. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 42: 16657-16662. DOI: 10.1073/pnas.0707936104
[5] ISLAM A.A.E.-H. IBRAHIM Hitoshi K. β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics[J]. Journal of pharmacological sciences, 2012, 118 4: Pages 408-412. DOI: 10.1254/jphs.11r10cp
[6] HAMED M I A, DARWISH K M, SOLTANE R, et al. β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization[J]. RSC Advances, 2021, 56: 35536-35558. DOI: 10.1039/d1ra04820a
CARVEDILOL-D5 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1949 | 55 |
| Clearsynth Canada Inc. | +1.415.685.4395 | enquiry@clearsynth.com | Canada | 912 | 58 |
| PI & PI BIOTECH INC. | +86-13602409664 +86-17788709170 | Sales@pipitech.com | China | 2644 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2469 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Manhag Testing Technology Co., Ltd | 400-818 0104 18918165978 | yanyan.guo@bestown.net.cn | China | 7770 | 58 |
| Foshan Treasure Biotechnology Co., Ltd | 0757-85921206 18520245316 | 2329783215@qq.com | China | 12649 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24318 | 58 |
