2-AMINO-4-CHLOROBENZOTHIAZOLE
- CAS No.
- 19952-47-7
- Chemical Name:
- 2-AMINO-4-CHLOROBENZOTHIAZOLE
- Synonyms
- AKOS BB-8273;ASISCHEM A34695;TIMTEC-BB SBB000250;LABOTEST-BB LT00012587;4-Chlorobenzothiazol-2-amine;4-Chloro-2-benzothiazolamine;2-Amino-4-chlorbenzothiazole;4-Chlorbenzothiazol-2-ylamin;2-amino-4-chloro-benzothiazol;2-AMINO-4-CHLOROBENZOTHIAZOLE
- CBNumber:
- CB5707744
- Molecular Formula:
- C7H5ClN2S
- Molecular Weight:
- 184.65
- MDL Number:
- MFCD00005791
- MOL File:
- 19952-47-7.mol
- MSDS File:
- SDS
| Melting point | 203-205 °C (lit.) |
|---|---|
| Boiling point | 344.3±34.0 °C(Predicted) |
| Density | 1.4750 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 2.14±0.10(Predicted) |
| color | White to light beige or grayish |
| BRN | 136784 |
| InChIKey | OEQQFQXMCPMEIH-UHFFFAOYSA-N |
| CAS DataBase Reference | 19952-47-7(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Amino-4-chlorobenzothiazole (19952-47-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DL1225000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29342080 | |||||||||
| NFPA 704 |
|
2-AMINO-4-CHLOROBENZOTHIAZOLE price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 133434 | 2-Amino-4-chlorobenzothiazole 97% | 19952-47-7 | 5g | $24.1 | 2025-07-31 | Buy |
| Sigma-Aldrich | 133434 | 2-Amino-4-chlorobenzothiazole 97% | 19952-47-7 | 25g | $56.9 | 2025-07-31 | Buy |
| TCI Chemical | A1087 | 2-Amino-4-chlorobenzothiazole >98.0%(HPLC) | 19952-47-7 | 5g | $116 | 2025-07-31 | Buy |
| TCI Chemical | A1087 | 2-Amino-4-chlorobenzothiazole >98.0%(HPLC) | 19952-47-7 | 25g | $442 | 2025-07-31 | Buy |
| TRC | A603265 | 2-Amino-4-chlorobenzothiazole | 19952-47-7 | 1g | $120 | 2021-12-16 | Buy |
2-AMINO-4-CHLOROBENZOTHIAZOLE Chemical Properties,Uses,Production
Chemical Properties
white to light beige or greyish crystalline powder
Uses
2-Amino-4-chlorobenzothiazole is a benzothiazole derivative that shows in vivo antiviral effects against various influenza A2 strains.
General Description
Cream colored crystalline solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A halogenated amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 2-AMINO-4-CHLOROBENZOTHIAZOLE emits very toxic fumes of chloride ion, SOx and NOx.
Fire Hazard
Flash point data for 2-AMINO-4-CHLOROBENZOTHIAZOLE are not available; however, 2-AMINO-4-CHLOROBENZOTHIAZOLE is probably combustible.
Synthesis
333-20-0
95-51-2
19952-47-7
GENERAL METHOD: A solution of o-chloroaniline (2 mmol) in acetonitrile (15 mL) was slowly added to a solution of potassium thiocyanate (8 mmol) in acetonitrile (15 mL). Subsequently, nano BF3/SiO2 catalyst (0.06 g, 30 mol% BF3) was added to the reaction system and the mixture was placed in an ice-salt bath and mechanically stirred for 30 min. A solution of bromine (4 mmol, 0.2 mL) in acetonitrile (3 mL) was slowly added through a dropping funnel, and the rate of dropping was controlled to ensure that the reaction temperature did not exceed 0 °C. After the bromine solution was added, the reaction mixture continued to be stirred at room temperature for 4 h, during which the progress of the reaction was monitored by TLC. Upon completion of the reaction, the mixture was poured into water and heated to 70 °C on a steam bath followed by thermal filtration to isolate the catalyst. The catalyst was washed with acetone and recycled for reuse. The filtrate was neutralized with 10% NaOH solution and the resulting precipitate was collected by filtration, dried and recrystallized from ethanol (10 mL) to give the target product 2-amino-4-chlorobenzothiazole. All products were characterized by physical properties and spectral data including FT-IR, 1H NMR and 13C NMR and confirmed by comparison with known standards.
References
[1] Synlett, 2012, vol. 23, # 15, p. 2219 - 2222
[2] Research on Chemical Intermediates, 2016, vol. 42, # 12, p. 7855 - 7868
[3] Patent: WO2017/25980, 2017, A2. Location in patent: Page/Page column 9; 12
[4] Asian Journal of Chemistry, 2011, vol. 23, # 9, p. 3969 - 3974
[5] European Journal of Medicinal Chemistry, 2013, vol. 67, p. 1 - 13
2-AMINO-4-CHLOROBENZOTHIAZOLE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | sales@saferph.com | CHINA | 897 | 58 |
View Lastest Price from 2-AMINO-4-CHLOROBENZOTHIAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-15 | 4-chloro-1,3-benzothiazol-2-amine
19952-47-7
|
US $0.00 / KG | 1KG | 99.4% | 100 tons | Honest Joy Holdings Limited | |
 |
2021-07-02 | 2-AMINO-4-CHLOROBENZOTHIAZOLE
19952-47-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-13 | 2-AMINO-4-CHLOROBENZOTHIAZOLE
19952-47-7
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 4-chloro-1,3-benzothiazol-2-amine
19952-47-7
- US $0.00 / KG
- 99.4%
- Honest Joy Holdings Limited
-
- 2-AMINO-4-CHLOROBENZOTHIAZOLE
19952-47-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-AMINO-4-CHLOROBENZOTHIAZOLE
19952-47-7
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
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