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4-Piperidinemethanol

4-Piperidinemethanol Structure
4-Piperidinemethanol structure
CAS No.
6457-49-4
Chemical Name:
4-Piperidinemethanol
Synonyms
PIPERIDIN-4-YLMETHANOL;PiperidineMethanol;piperidin-4-ylmethanol hydrochloride;4-PIPERIDYLMETHANOL;4-(HYDROXYMETHYL)PIPERIDINE;55-59℃;BUTTPARK 27\08-74;4-piperdinemethanol;4-PIPERIDINEMETHANOL;4-Piperidinecarbinol
CBNumber:
CB5710894
Molecular Formula:
C6H13NO
Molecular Weight:
115.17
MDL Number:
MFCD00174228
MOL File:
6457-49-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-09 12:03:46
Product description Number Pack Size Price
4-Piperidinemethanol 97% 497312 5g $216
4-Piperidinemethanol 97% 497312 25g $1050
4-Piperidinemethanol >97.0%(GC)(T) P1653 5g $48
4-Piperidinemethanol >97.0%(GC)(T) P1653 25g $145
4-Piperidinemethanol TRC-P481945-2.5G 2.5g $262
More product size
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4-Piperidinemethanol Properties

Melting point 55-59 °C(lit.)
Boiling point 118-120 °C10 mm Hg(lit.)
Density 0,997 g/cm3
Flash point >230 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
Water Solubility Soluble in water
form Crystalline Powder, Chunks and/or Solid
pka 14.94±0.10(Predicted)
color White to off-white
Sensitive Hygroscopic
BRN 103071
InChI InChI=1S/C6H13NO/c8-5-6-1-3-7-4-2-6/h6-8H,1-5H2
InChIKey XBXHCBLBYQEYTI-UHFFFAOYSA-N
SMILES N1CCC(CO)CC1
CAS DataBase Reference 6457-49-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C,Xi
Risk Statements  34-22
Safety Statements  26-27-36/37/39-45
RIDADR  UN 3263 8/PG 2
WGK Germany  3
Hazard Note  Irritant/Hygroscopic
HazardClass  8
PackingGroup  III
HS Code  29333990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
Limited Quantities 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
0
3 1

4-Piperidinemethanol price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 497312 4-Piperidinemethanol 97% 6457-49-4 5g $216 2026-04-30 Buy
Sigma-Aldrich 497312 4-Piperidinemethanol 97% 6457-49-4 25g $1050 2026-04-30 Buy
TCI Chemical P1653 4-Piperidinemethanol >97.0%(GC)(T) 6457-49-4 5g $48 2026-04-30 Buy
TCI Chemical P1653 4-Piperidinemethanol >97.0%(GC)(T) 6457-49-4 25g $145 2026-04-30 Buy
TRC TRC-P481945-2.5G 4-Piperidinemethanol 6457-49-4 2.5g $262 2026-06-03 Buy
Product number Packaging Price Buy
497312 5g $216 Buy
497312 25g $1050 Buy
P1653 5g $48 Buy
P1653 25g $145 Buy
TRC-P481945-2.5G 2.5g $262 Buy

4-Piperidinemethanol Chemical Properties,Uses,Production

Chemical Properties

white to off-white crystalline powder, chunks

Uses

4-Piperidinemethanol may be used in the preparation of:

  • N-tert-butoxycarbonyl-4-hydroxymethyl piperidine
  • desferrioxamine B (DFO) containing third generation triazine dendrimer
  • ethyl 3-(4-(hydroxymethyl)piperidin-1-yl)propanoate (EHMPP)
  • 4-(hydroxymethyl)piperidine-1-carbodithioic acid (HL)
  • 1-[[(1E)-2-(4-chlorophenyl)ethenyl]sulfonyl]-4-piperidinemethanol

General Description

4-Piperidinemethanol is a cyclic secondary amine. Its standard molar enthalpies of combustion, sublimation and formation have been determined.

Synthesis

Ethyl 4-piperidinecarboxylate

1126-09-6

4-Piperidinemethanol

6457-49-4

The general procedure for the synthesis of 4-hydroxymethylpiperidine from ethyl 4-piperidinecarboxylate was as follows: lithium aluminum hydride (LiAlH4, 10.10 g, 0.266 mol) was suspended in tetrahydrofuran (THF, 150 mL) at 0 °C. Subsequently, a solution of ethyl 4-piperidinecarboxylate (18.13 g, 0.120 mol) dissolved in THF (300 mL) was slowly added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, it was cooled in an ice bath and a mixture of water (14 mL) and THF (28 mL) was slowly added. Next, a mixture of 15% aqueous sodium hydroxide (14 mL) and water (37 mL) was added and stirring was continued for 30 minutes at room temperature. The reaction mixture was filtered to remove the precipitate and the filtrate was concentrated to give 17.88 g of the target product 4-hydroxymethylpiperidine in quantitative yield.

References

[1] Patent: WO2004/76450, 2004, A1. Location in patent: Page 59
[2] Patent: WO2010/12611, 2010, A1. Location in patent: Page/Page column 27
[3] RSC Advances, 2016, vol. 6, # 22, p. 17929 - 17940
[4] European Journal of Medicinal Chemistry, 2019, p. 234 - 248
[5] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 773 - 791

4-Piperidinemethanol synthesis

1126-09-6
6457-49-4
Synthesis of 4-Piperidinemethanol from Ethyl 4-piperidinecarboxylate

4-Piperidinemethanol Preparation Products And Raw materials

Raw materials

Ethyl 4-piperidinecarboxylate 2H-Pyran-4-carboxylic acid, tetrahydro-4-[(4-hydroxy-1-piperidinyl)sulfonyl]-, 1,1-dimethylethyl ester Sodium hydroxide Tetrahydrofuran 2-Piperidinone, 4-(methoxymethyl)-
4-Methoxy-7-Morpholinobenzo[d]thiazol-2-aMine N-Boc-4-piperidinemethanol ETHYL 1-PIPERIDINECARBOXYLATE 4-(METHOXYMETHYL)PIPERIDINE 1-Iodoheptane

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Preparation Products

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 2-(4-Chloromethylpiperidin-1-yl)pyrimidine-5-carboxamide ,97% 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxamide 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
(2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidin-5-yl)methanol 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate 2-(4-(Hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide 1-Boc-4-(aminomethyl)piperidine Terfenadine
Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate (1-(4-(Hydroxymethyl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yl)methanol

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4-Piperidinemethanol Suppliers

Global( 424)Suppliers
Supplier Tel Email Country ProdList Advantage
Siyang Liaoning Biochemical Products Co. Ltd
+86-15221114306; +86-15221114306 2594582574@qq.com China 561 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8738 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20120 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Shanghai Bojing Chemical Co.,Ltd. 		+86-86-02137122233 +86-13795318958 bj1@bj-chem.com China 299 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Shanxi Naipu Import and Export Co.,Ltd 		+86-13734021967 13734021967 kaia@neputrading.com China 1001 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Accela ChemBio Inc. 		+1-858-6993322 +86-18019713315 info@accelachem.com United States 21193 58
Supplier Advantage
Siyang Liaoning Biochemical Products Co. Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Shanghai Bojing Chemical Co.,Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Shanxi Naipu Import and Export Co.,Ltd 		58
career henan chemical co 		58
Accela ChemBio Inc. 		58

View Lastest Price from 4-Piperidinemethanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Piperidinemethanol pictures 2026-07-09 4-Piperidinemethanol
6457-49-4
 $1.20-35.00 1kg 99% Henan Fengda Chemical Co., Ltd
4-Piperidinemethanol pictures 2026-07-08 4-Piperidinemethanol
6457-49-4
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
4-Piperidinemethanol pictures 2026-03-20 4-Piperidinemethanol
6457-49-4
 $10.00 1KG 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd

4-Piperidinemethanol Spectrum

4-Piperidinemethanol(6457-49-4)1HNMR

6457-49-4(4-Piperidinemethanol)Related Search:

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PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Isonipecotamide Methyl 4-piperidinecarboxylate Methyl isonipecotate
Ethyl 4-piperidinecarboxylate Isonipecotic acid 4,4-Piperidinediol hydrochloride Tris(hydroxymethyl)aminomethane 2,2,6,6-Tetramethyl-4-piperidinol
Isonipecotic acid hydrochloride 3-Quinuclidinol hydrochloride Piperidine

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4-(Hydroxymethyl)piperidine, 98 % (NMR+TLC) Piperidine-4-methanol 4-Piperidinemethanol ,98% piperidin-4-ylmethanol hydrochloride 2-HydroMethyl piperidine 4-PiperidineMethanol, 98% 5GR 4-PiperidineMethanol or 4-(HydroxyMethyl)piperidine 4-PiperidineMethanol 97% 4-PiperidineMethanol, 97+% China 4-Piperidinemethanol (4-Piperidinyl)methanol PIPERIDINEMETHANOL(4-) 4-(HYDROXYMETHYL)PIPERIDINE 4-PIPERIDINEMETHANOL 4-PIPERIDYLMETHANOL BUTTPARK 27\08-74 4-Piperidinecarbinol 4-Piperidine-methanol(4-(Hydroxymethyl)-piperidine) 4-piperdinemethanol 4-(Hydroxymethyl)piperidine 97% 55-59℃ 4-PIPERIDINEMETHANOL 99.5+% 4-HYDROXYMETHYLPIPERIDINE PIPERIDIN-4-YL-METHANOL 4-Piperidine-methanol(4-(Hydroxymethyl)-piperi 4-Piperidinemethanol> 4- piperidinyl alcohol 4-PIPERIDINEMETHANOL, PYPERIDINEMETHANOL 4-Piperidinemethanol (6CI, 7CI, 9CI, ACI) Butenafine Impurity 36 4-Piperidinemethanol, 95% PiperidineMethanol PIPERIDIN-4-YLMETHANOL 6457-49-4 Heterocyclic Building Blocks Piperidines Building Blocks Piperidine Series Pyrans, Piperidines & Piperazines Alkohols pharmacetical PiperidineDerivative Hydroxymethyl's Pyrans, Piperidines &Piperazines Piperidine Alcohols and Derivatives Amines and Anilines