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4-Piperidinemethanol

4-Piperidinemethanol structure

CAS No.: 6457-49-4

Chemical Name:: 4-Piperidinemethanol

Synonyms: PIPERIDIN-4-YLMETHANOL;piperidin-4-ylmethanol hydrochloride;PiperidineMethanol;4-PIPERIDYLMETHANOL;4-(HYDROXYMETHYL)PIPERIDINE;55-59℃;BUTTPARK 27\08-74;4-piperdinemethanol;4-PIPERIDINEMETHANOL;4-Piperidinecarbinol

CBNumber:: CB5710894

Molecular Formula:: C6H13NO

Molecular Weight:: 115.17

MDL Number:: MFCD00174228

MOL File:: 6457-49-4.mol

MSDS File:: SDS

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
4-Piperidinemethanol 97%	497312	5g	$203
4-Piperidinemethanol 97%	497312	25g	$995
4-Piperidinemethanol >97.0%(GC)(T)	P1653	5g	$82
4-Piperidinemethanol >97.0%(GC)(T)	P1653	25g	$239
4-Piperidinemethanol	P481945	10g	$385
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4-Piperidinemethanol Properties

Melting point	55-59 °C(lit.)
Boiling point	118-120 °C10 mm Hg(lit.)
Density	0,997 g/cm³
Flash point	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Water Solubility	Soluble in water
form	Crystalline Powder, Chunks and/or Solid
pka	14.94±0.10(Predicted)
color	White to off-white
Sensitive	Hygroscopic
BRN	103071
InChI	InChI=1S/C6H13NO/c8-5-6-1-3-7-4-2-6/h6-8H,1-5H2
InChIKey	XBXHCBLBYQEYTI-UHFFFAOYSA-N
SMILES	N1CCC(CO)CC1
CAS DataBase Reference	6457-49-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

Hazard Codes

C,Xi

Risk Statements

34-22

Safety Statements

26-27-36/37/39-45

RIDADR

UN 3263 8/PG 2

WGK Germany

Hazard Note

Irritant/Hygroscopic

HazardClass

PackingGroup

III

HS Code

29333990

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	0
3		1

4-Piperidinemethanol price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	497312	4-Piperidinemethanol 97%	6457-49-4	5g	$203	2025-07-31	Buy
Sigma-Aldrich	497312	4-Piperidinemethanol 97%	6457-49-4	25g	$995	2025-07-31	Buy
TCI Chemical	P1653	4-Piperidinemethanol >97.0%(GC)(T)	6457-49-4	5g	$82	2025-07-31	Buy
TCI Chemical	P1653	4-Piperidinemethanol >97.0%(GC)(T)	6457-49-4	25g	$239	2025-07-31	Buy
TRC	P481945	4-Piperidinemethanol	6457-49-4	10g	$385	2021-12-16	Buy

Product number	Packaging	Price	Buy
497312	5g	$203	Buy
497312	25g	$995	Buy
P1653	5g	$82	Buy
P1653	25g	$239	Buy
P481945	10g	$385	Buy

4-Piperidinemethanol Chemical Properties,Uses,Production

Chemical Properties

white to off-white crystalline powder, chunks

Uses

4-Piperidinemethanol may be used in the preparation of:

N-tert-butoxycarbonyl-4-hydroxymethyl piperidine
desferrioxamine B (DFO) containing third generation triazine dendrimer
ethyl 3-(4-(hydroxymethyl)piperidin-1-yl)propanoate (EHMPP)
4-(hydroxymethyl)piperidine-1-carbodithioic acid (HL)
1-[[(1E)-2-(4-chlorophenyl)ethenyl]sulfonyl]-4-piperidinemethanol

General Description

4-Piperidinemethanol is a cyclic secondary amine. Its standard molar enthalpies of combustion, sublimation and formation have been determined.

Synthesis

1126-09-6

6457-49-4

The general procedure for the synthesis of 4-hydroxymethylpiperidine from ethyl 4-piperidinecarboxylate was as follows: lithium aluminum hydride (LiAlH4, 10.10 g, 0.266 mol) was suspended in tetrahydrofuran (THF, 150 mL) at 0 °C. Subsequently, a solution of ethyl 4-piperidinecarboxylate (18.13 g, 0.120 mol) dissolved in THF (300 mL) was slowly added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, it was cooled in an ice bath and a mixture of water (14 mL) and THF (28 mL) was slowly added. Next, a mixture of 15% aqueous sodium hydroxide (14 mL) and water (37 mL) was added and stirring was continued for 30 minutes at room temperature. The reaction mixture was filtered to remove the precipitate and the filtrate was concentrated to give 17.88 g of the target product 4-hydroxymethylpiperidine in quantitative yield.

References

[1] Patent: WO2004/76450, 2004, A1. Location in patent: Page 59
[2] Patent: WO2010/12611, 2010, A1. Location in patent: Page/Page column 27
[3] RSC Advances, 2016, vol. 6, # 22, p. 17929 - 17940
[4] European Journal of Medicinal Chemistry, 2019, p. 234 - 248
[5] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 773 - 791

4-Piperidinemethanol synthesis

Synthesis of 4-Piperidinemethanol from Ethyl 4-piperidinecarboxylate

4-Piperidinemethanol Preparation Products And Raw materials

Raw materials

Ethyl 4-piperidinecarboxylate 2H-Pyran-4-carboxylic acid, tetrahydro-4-[(4-hydroxy-1-piperidinyl)sulfonyl]-, 1,1-dimethylethyl ester Sodium hydroxide Tetrahydrofuran 2-Piperidinone, 4-(methoxymethyl)-

4-Methoxy-7-Morpholinobenzo[d]thiazol-2-aMine N-Boc-4-piperidinemethanol ETHYL 1-PIPERIDINECARBOXYLATE 4-(METHOXYMETHYL)PIPERIDINE 1-Iodoheptane

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Preparation Products

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 2-(4-Chloromethylpiperidin-1-yl)pyrimidine-5-carboxamide ,97% 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxamide 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate

(2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidin-5-yl)methanol 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate 2-(4-(Hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide 1-Boc-4-(aminomethyl)piperidine Terfenadine

Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate (1-(4-(Hydroxymethyl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yl)methanol

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4-Piperidinemethanol Suppliers

Global( 433)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Siyang Liaoning Biochemical Products Co. Ltd	+86-15221114306; +8615221114306	2594582574@qq.com	China	561	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20175	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	299	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1001	58

Supplier	Advantage
Siyang Liaoning Biochemical Products Co. Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Shanghai Bojing Chemical Co.,Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Zjartschem	58
Shanxi Naipu Import and Export Co.,Ltd	58

View Lastest Price from 4-Piperidinemethanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	4-Piperidinemethanol 6457-49-4	US $10.00 / KG	1KG	99%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	4-Piperidinemethanol 6457-49-4	US $35.00-1.20 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-01-03	4-Piperidinemethanol 6457-49-4	US $0.00-0.00 / KG	1g	99%	2000tons	Shaanxi Dideu Medichem Co. Ltd

4-Piperidinemethanol
6457-49-4
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Piperidinemethanol
6457-49-4
US $35.00-1.20 / kg
99%
Henan Fengda Chemical Co., Ltd

4-Piperidinemethanol
6457-49-4
US $0.00-0.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

4-Piperidinemethanol Spectrum

4-Piperidinemethanol(6457-49-4)¹HNMR

6457-49-4(4-Piperidinemethanol)Related Search:

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Methyl isonipecotate Ethyl 4-piperidinecarboxylate Isonipecotic acid 4,4-Piperidinediol hydrochloride Tris(hydroxymethyl)aminomethane

Isonipecotic acid hydrochloride 3-Quinuclidinol hydrochloride Piperidine

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4-(Hydroxymethyl)piperidine, 98 % (NMR+TLC) Piperidine-4-methanol 4-Piperidinemethanol ,98% piperidin-4-ylmethanol hydrochloride 2-HydroMethyl piperidine 4-PiperidineMethanol, 98% 5GR 4-PiperidineMethanol or 4-(HydroxyMethyl)piperidine PiperidineMethanol 4-PiperidineMethanol 97% 4-PiperidineMethanol, 97+% China 4-Piperidinemethanol (4-Piperidinyl)methanol PIPERIDIN-4-YLMETHANOL PIPERIDINEMETHANOL(4-) 4-(HYDROXYMETHYL)PIPERIDINE 4-PIPERIDINEMETHANOL 4-PIPERIDYLMETHANOL BUTTPARK 27\08-74 4-Piperidinecarbinol 4-Piperidine-methanol(4-(Hydroxymethyl)-piperidine) 4-piperdinemethanol 4-(Hydroxymethyl)piperidine 97% 55-59℃ 4-PIPERIDINEMETHANOL 99.5+% 4-HYDROXYMETHYLPIPERIDINE PIPERIDIN-4-YL-METHANOL 4-Piperidine-methanol(4-(Hydroxymethyl)-piperi 4-Piperidinemethanol> 4- piperidinyl alcohol 4-PIPERIDINEMETHANOL, PYPERIDINEMETHANOL 4-Piperidinemethanol (6CI, 7CI, 9CI, ACI) Butenafine Impurity 36 4-Piperidinemethanol, 95% 6457-49-4 Heterocyclic Building Blocks Piperidines Building Blocks Piperidine Series Pyrans, Piperidines & Piperazines Alkohols pharmacetical PiperidineDerivative Hydroxymethyl's Pyrans, Piperidines &Piperazines Piperidine Alcohols and Derivatives Amines and Anilines