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Lomefloxacin hydrochloride

Lomefloxacin hydrochloride Structure
Lomefloxacin hydrochloride structure
CAS No.
98079-52-8
Chemical Name:
Lomefloxacin hydrochloride
Synonyms
LOMEFLOXACIN HCL;1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride;ny198;omefL;Okacyn;Okacin;bareon;Chimono;Uniquin;LoMflox
CBNumber:
CB5723616
Molecular Formula:
C17H20ClF2N3O3
Molecular Weight:
387.81
MDL Number:
MFCD00214312
MOL File:
98079-52-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
Lomefloxacin hydrochloride L2906 1g $84.7
Lomefloxacin hydrochloride L2906 10g $505
Lomefloxacin Hydrochloride >98.0%(HPLC)(T) L0216 5g $65
Lomefloxacin Hydrochloride >98.0%(HPLC)(T) L0216 25g $277
Lomefloxacin (hydrochloride) ≥98% 28271 5g $81
More product size
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Lomefloxacin hydrochloride Properties

Melting point 290-3000C
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility 1 M NaOH: soluble50mg/mL
form powder to crystal
color white to off-white
biological source synthetic
Merck 14,5562
InChI InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
InChIKey KXEBLAPZMOQCKO-UHFFFAOYSA-N
SMILES N1(CC)C2=C(C=C(F)C(N3CCNC(C)C3)=C2F)C(=O)C(C(O)=O)=C1.[H]Cl
CAS DataBase Reference 98079-52-8(CAS DataBase Reference)
FDA UNII 9VC7S3ZXXB
UNSPSC Code 51282927
NACRES NA.85

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P261-P264-P270-P272-P280-P301+P312+P330-P302+P352+P333+P313+P363-P501
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  VB1997500
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
0
1 0

Lomefloxacin hydrochloride price More Price(81)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L2906 Lomefloxacin hydrochloride 98079-52-8 1g $84.7 2026-04-30 Buy
Sigma-Aldrich L2906 Lomefloxacin hydrochloride 98079-52-8 10g $505 2026-04-30 Buy
TCI Chemical L0216 Lomefloxacin Hydrochloride >98.0%(HPLC)(T) 98079-52-8 5g $65 2026-04-30 Buy
TCI Chemical L0216 Lomefloxacin Hydrochloride >98.0%(HPLC)(T) 98079-52-8 25g $277 2023-06-20 Buy
Cayman Chemical 28271 Lomefloxacin (hydrochloride) ≥98% 98079-52-8 5g $81 2026-04-30 Buy
Product number Packaging Price Buy
L2906 1g $84.7 Buy
L2906 10g $505 Buy
L0216 5g $65 Buy
L0216 25g $277 Buy
28271 5g $81 Buy

Lomefloxacin hydrochloride Chemical Properties,Uses,Production

Description

Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.

Description

Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic. In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC90 = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth. Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.

Chemical Properties

White powder with no smell, bitter taste

Originator

Foxil,Sarabhai Chemicals,India

Uses

Fluorinated quinolone antibacterial. DNA gyrase antagonist

Definition

ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for he treatment of otitis externa and otitis media.

Manufacturing Process

A mixture of 1.00 g of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid, 1.10 g of 2-methylpiperazine and 10 ml of pyridine was heated for 15 minutes under reflux. The reaction mixture was evaporated and methanol was added to the residue. The precipitate was filtered and recrystallized from ethanol to give 0.36 g of the 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid as colorless needles, melting point 239.0-240.5°C.
By the usual manner the hydrochloride was prepared and recrystallized from water as colorless needles, melting point 290-300°C (decomp.).

brand name

Maxaquin (Pharmacia).

Therapeutic Function

Antibacterial

References

Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.

Lomefloxacin hydrochloride Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 2-Methylpiperazine 1,2,3-Trifluoro-4-nitrobenzene Bromoethane Pyridine
Sodium bicarbonate 1-Ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-2-quinolinecarboxylic acid

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Preparation Products

Lomefloxacin

Lomefloxacin hydrochloride Suppliers

Global( 427)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20120 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6366 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460 faith@widelychemical.com CHINA 742 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32466 58
Longyan Tianhua Biological Technology Co., Ltd 		0086 18039857276 18039857276 CHINA 2783 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58
HubeiwidelychemicaltechnologyCo.,Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Longyan Tianhua Biological Technology Co., Ltd 		58

View Lastest Price from Lomefloxacin hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lomefloxacin hydrochloride pictures 2026-07-31 Lomefloxacin hydrochloride
98079-52-8
 1KG 99.5~101.0% 5ton/month WUHAN FORTUNA CHEMICAL CO., LTD
Lomefloxacin hydrochloride pictures 2026-07-15 Lomefloxacin hydrochloride
98079-52-8
 $37.00 99.86% 10g TargetMol Chemicals Inc.
Lomefloxacin hydrochloride pictures 2026-07-09 Lomefloxacin hydrochloride
98079-52-8
 $1.30-32.00 1KG 99% Henan Fengda Chemical Co., Ltd

Lomefloxacin hydrochloride Spectrum

Lomefloxacin hydrochloride(98079-52-8)1HNMR

98079-52-8(Lomefloxacin hydrochloride)Related Search:

N-Aminoethylpiperazine Methanol Paraquat dichloride Methyl acrylate Isoquinoline
Topotecan hydrochloride Dihydromyrcenol Ethoxyquin Quinclorac Methyl acetate
Lomefloxacin Basic Violet 1 Methylparaben 2-Ethylhexyl ferulate Kresoxim-methyl
Acetonitrile Methyl 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride

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1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacimonohydrochloride bareon ny198 sc-47111 1-ETHYL-6,8-DIFLUORO-1,4-DIHYDRO-7-[3-METHYL-1-PIPERAZINYL]-4-OXO-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE LOMEFLOXACIN HYDROCHLORIDE Chimono Lomebact Maxaquin Okacin Okacyn 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride (9CI) Mazaquin Uniquin 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acimonohydrochloride bareonny Lomoefloxacin HCL LomefloxacineHCl 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride Lomefloxacin hydroch Hydrochloric acid fleroxacin LoMefloxacin hydrochloride (Maxaquin) Alkaflox LoMef 400 LoMflox LoMitas LoMoxin Orchacin Lomeflon Lomefloxcin hydrochloride Lomefloxacin hydrochloride,1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 1-Ethyl-6,8-difluoro-7-(3-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride Lomefloxacin h 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, hydrochloride (1:1) Lomefloxacin·HCl≥ 99% (HPLC) omefL Lomefloxacin Hydrochloride Standard LomefloxacinHydrochloride> Lomefloxacin hydrochloride USP/EP/BP Lomefloxacin HydrochlorideQ: What is Lomefloxacin Hydrochloride Q: What is the CAS Number of Lomefloxacin Hydrochloride Q: What is the storage condition of Lomefloxacin Hydrochloride Q: What are the applications of Lomefloxacin Hydrochloride Lomefloxacin Hydrochloride (LMF), 98.5% C14646000 Lomefloxacin hydrochloride D5-Lomefloxacin hydrochloride LOMEFLOXACIN HCL 98079-52-8 C17H19F2N3O3HCl C17H20ClF2N3O3 C17H19F2N3O3ClH Halogenated Heterocycles ,Benzothiazoles Antibiotics for Research and Experimental Use Biochemistry Quinolones (Antibiotics for Research and Experimental Use) Intermediates & Fine Chemicals Pharmaceuticals Lomefloxacin