HOECHST 34580
- CAS No.
- 23555-00-2
- Chemical Name:
- HOECHST 34580
- Synonyms
- ProaMine;HOE 34580;HOECHST 34580;Hoechst 34580 ，S0486;Hoechst 34580 (HOE 34580);2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
- CBNumber:
- CB5729663
- Molecular Formula:
- C27H29N7
- Molecular Weight:
- 451.57
- MDL Number:
- MFCD25541584
- MOL File:
- 23555-00-2.mol
| Product description | Number | Pack Size | Price |
| Hoechst 34580 ≥98%(HPLC) | CDX-B0094-M005 | 5mg | $59 |
| Hoechst 34580 99.84% | CS-1303 | 5mg | $72 |
| Hoechst 34580 99.84% | CS-1303 | 10mg | $108 |
| Hoechst 34580 | A3475 | 25mg | $112 |
| Hoechst 34580 99.84% | CS-1303 | 50mg | $288 |
| More product size | |||
| Melting point | >300℃ |
|---|---|
| Boiling point | 733.2±70.0 °C(Predicted) |
| Density | 1.280±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in dimethyl sulfoxide, water |
| form | powder |
| pka | 10.97±0.10, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic(at 25℃) |
| color | Yellow to green |
| Appearance | Yellow Solid |
| λmax | 392nm |
| Biological Applications | Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing |
HOECHST 34580 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Adipogen Life Sciences | CDX-B0094-M005 | Hoechst 34580 ≥98%(HPLC) | 23555-00-2 | 5mg | $59 | 2021-12-16 | Buy |
| ChemScene | CS-1303 | Hoechst 34580 99.84% | 23555-00-2 | 5mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-1303 | Hoechst 34580 99.84% | 23555-00-2 | 10mg | $108 | 2021-12-16 | Buy |
| ApexBio Technology | A3475 | Hoechst 34580 | 23555-00-2 | 25mg | $112 | 2021-12-16 | Buy |
| ChemScene | CS-1303 | Hoechst 34580 99.84% | 23555-00-2 | 50mg | $288 | 2021-12-16 | Buy |
HOECHST 34580 Chemical Properties,Uses,Production
Description
Hoechst 34580 is one of Hoechst stains which are Bis-benzimides used as blue fluorescent dyes to stain DNA.
Uses
Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1].
Biological Activity
Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye used to stain DNA and cell nuclei. It is also a good candidate for the treatment of Alzheimer's disease by inhibiting the formation of amyloid beta (Aβ) with an IC50 value of 0.86 μM.
in vitro
Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC 50 of 0.86±0.05 μM for Hoechst 34580. It is a good candidate for treating the Alzheimer's disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose- dependent manner. And the half-maximal concentration (IC 50 ) is examined. The IC 50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86 ±0.05 μM for Hoechst 34580.
target
| Target | Value |
| Aβ (Cell-free assay) | 0.86 μM |
References
[1] Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50. DOI:10.1007/s10822-016-9932-1
HOECHST 34580 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2990 | 60 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| TargetMol Chemicals Inc. | 58 |
| InvivoChem | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
| AdooQ BioScience, LLC | 58 |
| Bide Pharmatech Ltd. | 60 |
| AdooQ Bioscience CHINA | 60 |
| SPIRO PHARMA | 55 |
View Lastest Price from HOECHST 34580 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-26 | Hoechst 34580
23555-00-2
|
US $302.00 / mg | 98.84% | 10g | TargetMol Chemicals Inc. |
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- Hoechst 34580
23555-00-2
- US $302.00 / mg
- 98.84%
- TargetMol Chemicals Inc.
