5-Amino-2-methylbenzoic acid
- CAS No.
- 2840-04-2
- Chemical Name:
- 5-Amino-2-methylbenzoic acid
- Synonyms
- TIMTEC-BB SBB007566;RARECHEM AL BO 1282;5-Amino-2-methylbenz;5-Amino-o-toluic acid;2-Methyl-5-Aminobenzoic;2-METHYL-5-AMINOBENZOIC ACID;5-AMINO-2-METHYL-BENZOIC ACID;METHYL 5-AMION-2-METHYLBENZOATE;Benzoic acid, 5-amino-2-methyl-;5-Amino-2-methylbenzoic Acid >
- CBNumber:
- CB5732692
- Molecular Formula:
- C8H9NO2
- Molecular Weight:
- 151.16
- MDL Number:
- MFCD06208351
- MOL File:
- 2840-04-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Amino-2-methylbenzoic Acid >98.0%(T) | A2373 | 5g | $94 |
| 5-Amino-2-methylbenzoic Acid >98.0%(T) | A2373 | 25g | $283 |
| 5-Amino-2-methylbenzoic acid ≥98%(HPLC) | 28928 | 1G | $27.34 |
| 5-Amino-2-methylbenzoic acid ≥98%(HPLC) | 28928 | 5G | $77.62 |
| 5-Amino-2-methylbenzoic acid ≥98%(HPLC) | 28928 | 25G | $294.44 |
| More product size | |||
| Melting point | 194-199 °C |
|---|---|
| Boiling point | 348.8±30.0 °C(Predicted) |
| Density | 1.254±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Ethyl acetate (Very Slightly, Heated) |
| pka | 2.95±0.25(Predicted) |
| form | Solid |
| color | Light Brown |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C8H9NO2/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4H,9H2,1H3,(H,10,11) |
| InChIKey | FSXVZWAWYKMFMX-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(N)=CC=C1C |
| CAS DataBase Reference | 2840-04-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H302-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29224999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Amino-2-methylbenzoic acid price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2373 | 5-Amino-2-methylbenzoic Acid >98.0%(T) | 2840-04-2 | 5g | $94 | 2026-04-30 | Buy |
| TCI Chemical | A2373 | 5-Amino-2-methylbenzoic Acid >98.0%(T) | 2840-04-2 | 25g | $283 | 2026-04-30 | Buy |
| Chem-Impex | 28928 | 5-Amino-2-methylbenzoic acid ≥98%(HPLC) | 2840-04-2 | 1G | $27.34 | 2026-05-19 | Buy |
| Chem-Impex | 28928 | 5-Amino-2-methylbenzoic acid ≥98%(HPLC) | 2840-04-2 | 5G | $77.62 | 2026-05-19 | Buy |
| Chem-Impex | 28928 | 5-Amino-2-methylbenzoic acid ≥98%(HPLC) | 2840-04-2 | 25G | $294.44 | 2026-05-19 | Buy |
5-Amino-2-methylbenzoic acid Chemical Properties,Uses,Production
Chemical Properties
Beige powder
Uses
5-Amino-2-methylbenzoic Acid is used as a reagent in synthesis of several organic compounds including that of dihydroxylphenyl amides which are Hsp90 inhibitors. Also used in synthesis of a series of 2,5-diaminopyrimidine inhibitors of bruton’s tyrosine kinase with potential for use in cancer drug development.
Synthesis
1975-52-6
2840-04-2
General procedure for the synthesis of 5-amino-2-methylbenzoic acid from 2-methyl-5-nitrobenzoic acid: 2-methyl-5-nitrobenzoic acid (30.0 g, 0.166 mol) and Pd/C catalyst (1.8 g) were suspended in anhydrous methanol (1600 mL). The reaction mixture was stirred at 40 °C for 3 to 4 h at a hydrogen pressure of 50 Psi. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether: ethyl acetate = 1:2) and after confirming that the reaction was complete, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to afford 5-amino-2-methylbenzoic acid (24 g, 96% yield) as a white solid.1H NMR (400 MHz, CDCl3) data were as follows: δ 7.10 (s, 1H), 6.89-6.91 (d, J=8.0 Hz, 1H), 6.64-6.66 (dd, J=8.0 Hz, 1H), 2.31 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 17, p. 3343 - 3356
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6273 - 6278
[3] Patent: WO2006/117669, 2006, A1. Location in patent: Page/Page column 41; 114
[4] Tetrahedron, 2018, vol. 74, # 47, p. 6795 - 6803
[5] Chemische Berichte, 1883, vol. 16, p. 1959
5-Amino-2-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CE Pharm Co.,Ltd | +86 13816833708 | binbin.lin@cepharm.cn | CHINA | 52 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 5-Amino-2-methylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-29 | 5-Amino-2-methylbenzoic acid
2840-04-2
|
1kg | 98% | Changzhou waston chemical technology Co.,Ltd | |||
 |
2025-12-01 | 5-Amino-2-methylbenzoic acid
2840-04-2
|
1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-12-25 | 5-Amino-2-methylbenzoic acid
2840-04-2
|
1KG | 99% | 10tons | CE Pharm Co.,Ltd |
-
- 5-Amino-2-methylbenzoic acid
2840-04-2
- $0.00
- 98%
- Changzhou waston chemical technology Co.,Ltd
-
- 5-Amino-2-methylbenzoic acid
2840-04-2
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Amino-2-methylbenzoic acid
2840-04-2
- $0.00
- 99%
- CE Pharm Co.,Ltd
