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N-Ethylmaleimide

N-Ethylmaleimide structure

CAS No.: 128-53-0

Chemical Name:: N-Ethylmaleimide

Synonyms: NEM;1-ETHYL-1H-PYRROLE-2,5-DIONE;N-Ethylmaleinimide;1H-Pyrrole-2,5-dione, 1-ethyl-;NEMI;NSC 7638;N-Ethylm;NEMI/NEM;usafb-121;USAF B-121

CBNumber:: CB5748314

Molecular Formula:: C6H7NO2

Molecular Weight:: 125.13

MDL Number:: MFCD00005509

MOL File:: 128-53-0.mol

Last updated:2025-05-13 19:34:56

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N-Ethylmaleimide Properties

Melting point	43-46 °C(lit.)
Boiling point	210 °C(lit.)
Density	1.2500 (rough estimate)
refractive index	1.4430 (estimate)
Flash point	73 °C
storage temp.	2-8°C
solubility	methanol: 1 M at 20 °C, clear, colorless
form	Crystalline Powder
pka	-2.18±0.20(Predicted)
color	White to off-white
biological source	synthetic (organic)
Water Solubility	1 g/L (20 ºC)
Sensitive	Light Sensitive
Merck	14,3822
BRN	112448
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.
InChIKey	HDFGOPSGAURCEO-UHFFFAOYSA-N
CAS DataBase Reference	128-53-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	O3C74ACM9V
NIST Chemistry Reference	1H-pyrrole-2,5-dione, 1-ethyl-(128-53-0)
EPA Substance Registry System	N-Ethylmaleimide (128-53-0)
Absorption	cut-off at 382nm in methanol at 1M
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H300-H311-H314-H317

Precautionary statements

P260-P280-P301+P310+P330-P303+P361+P353-P305+P351+P338+P310

Hazard Codes

T+

Risk Statements

21-28-34-43-20/21

Safety Statements

26-28-36/37/39-45-28A

RIDADR

UN 2928 6.1/PG 2

WGK Germany

RTECS

UX9625000

TSCA

Yes

HazardClass

6.1

PackingGroup

HS Code

29251900

NFPA 704

	0
3		0

N-Ethylmaleimide price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	04260	N-Ethylmaleimide purum p.a., ≥99.0% (HPLC)	128-53-0	5G-F	$90.2	2024-03-01	Buy
Sigma-Aldrich	04260	N-Ethylmaleimide purum p.a., ≥99.0% (HPLC)	128-53-0	25G-F	$286	2024-03-01	Buy
Sigma-Aldrich	04259	N-Ethylmaleimide BioUltra, ≥99.0% (HPLC)	128-53-0	5g	$170	2024-03-01	Buy
Sigma-Aldrich	04259	N-Ethylmaleimide BioUltra, ≥99.0% (HPLC)	128-53-0	25g	$661	2024-03-01	Buy
Sigma-Aldrich	04260	N-Ethylmaleimide purum p.a., ≥99.0% (HPLC)	128-53-0	5G	$86.7	2023-01-07	Buy

Product number	Packaging	Price	Buy
04260	5G-F	$90.2	Buy
04260	25G-F	$286	Buy
04259	5g	$170	Buy
04259	25g	$661	Buy
04260	5G	$86.7	Buy

N-Ethylmaleimide Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

Reagent for the covalent modification of cysteine residues in proteins. NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.

Uses

In cancer research (possible antimitotic activity.)

Uses

N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.

Definition

ChEBI: N-ethylmaleimide is a member of the class of maleimides that is the N-ethyl derivative of maleimide. It has a role as an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, an EC 2.7.1.1 (hexokinase) inhibitor, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor and an anticoronaviral agent. It is functionally related to a maleimide.

Hazard

Lachrymator when liquid, a strong irritant.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.

Safety Profile

Poison by intraperitoneal route. Human mutation data reported. Vapors are hlghly irritating. When heated to decomposition it emits toxic fumes of NOx.

N-Ethylmaleimide synthesis

Synthesis of N-Ethylmaleimide from Maleic anhydride and Ethylamine hydrochloride

N-Ethylmaleimide Preparation Products And Raw materials

Raw materials

Maleic anhydride Paraffin, liquid Ethylamine N-ETHYLMALEAMIC ACID N-ETHYLMALEAMIC ACID

Ethylamine hydrochloride

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Preparation Products

3-(1-Ethyl-3-pyrrolidinyl)-1H-indole

N-Ethylmaleimide Suppliers

Global( 317)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29856	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32268	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from N-Ethylmaleimide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-05-13	N-Ethylmaleimide 128-53-0	US $39.00-82.00 / mg		99.92%	10g	TargetMol Chemicals Inc.
2021-07-13	N-Ethylmaleimide 128-53-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	N-Ethylmaleimide 128-53-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

N-Ethylmaleimide
128-53-0
US $39.00-82.00 / mg
99.92%
TargetMol Chemicals Inc.

N-Ethylmaleimide
128-53-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-Ethylmaleimide
128-53-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-Ethylmaleimide Spectrum

N-Ethylmaleimide(128-53-0)MS N-Ethylmaleimide(128-53-0)¹HNMR N-Ethylmaleimide(128-53-0)¹³CNMR N-Ethylmaleimide(128-53-0)IR1 N-Ethylmaleimide(128-53-0)IR2

128-53-0(N-Ethylmaleimide)Related Search:

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N,N'-1,3-Phenylene bismaleimide N-Phenylmaleimide DIALIFOS N-Succinimidyl 3-maleimidopropionate 3-MALEIMIDOPROPIONIC ACID

4-MALEIMIDOBUTYRIC ACID 3-Maleimidopropionic acid GMBS N-PROPYLMALEIMIDE N-Succinimidyl 6-maleimidohexanoate

N-Butylmaleimide 6-Maleimidocaproic acid 4-MALEIMIDO-TEMPO

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usafb-121 1-ETHYL-1H-PYRROLE-2,5-DIONE NEM N-ETHYLMALEIMIDE 1-Ethyl-1H-pyrrole-2,5-dione~NEM N-ETHYLMALEIMIDE SIGMAULTRA N-ETHYLMALEIMIDE 99+% N-EthylmaleimideA.R. N-Ethylmaleimide-D5 1H-Pyrrole-2,5-dione, 1-ethyl- 1-ETHYLPYRROLE-2,5-DIONE N-Ethylmaleinimid N-ETHYLMALEIMIDE extrapure 2,5-Dioxo-1-ethyl-3-pyrroline N-Ethylmaleinimide N-ETHYLMALEIMIDERESEARCH GRADE NEMI N-Ethylmaleimide, 98+% N-EthylMaleiMide(NEMI) N-EthylMaleiMide, 99+% 5GR NSC 7638 N-Ethylmaleimide - CAS 128-53-0 - Calbiochem 1-ethyl-1h-pyrrole-5-dione 5-dione,1-ethyl-1H-Pyrrole-2 ethvlmaleimide Ethylmaleimide Maleic acid N-ethylimide maleicacidn-ethylimide Maleimide, N-ethyl- n-ethvlmaleimide n-ethyl-maleimid USAF B-121 N-ETHYLMALEIMIDE BIOULTRA, >= 99.0% N-ETHYLMALEIMIDE BIOXTRA N-Ethylmaleimide≥ 99.5% (GC) N-Ethylmaleimide, 99%, reagent grade N-Ethylmaleimide> N-Ethylm N-Ethylmaleimide(NEMI),≥98% N-Ethylmaleimide ISO 9001：2015 REACH n-Ethylmaleimide, ≥99.0% (HPLC) N-Ethylmaleimide ExiPlus, Multi-Compendial, 99% N-ETHYL MALEIMIDE For Synthesis N-ETHYLMALEMIDE N-ETHYLMALEIMIDE NEM 1-Ethyl-1H-pyrrole-2,5-dione NEMI/NEM N-Ethyl Maleimide 99% (NEM) For Synthesis N-Ethylmaleimide, 10 mM in DMSO N-Ethylmaleimide NEM (N-Ethylmaleimide) 128-53-0 204-892-4 C6D5H2NO2 N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Maleimides Life Science Chemical Reagents N-Substituted Maleimides N-Substituted Maleimides, Succinimides & Phthalimides