2-Fluoro-4-iodo-5-picoline
- CAS No.
- 153034-94-7
- Chemical Name:
- 2-Fluoro-4-iodo-5-picoline
- Synonyms
- 2-Fluoro-4-iodo-5-methylpyridine;2-FLUORO-4-IODO-5-PICOLINE;6-Fluoro-4-iodo-b-picoline;6-Fluoro-4-iodo-3-picoline;Pyridine, 2-fluoro-4-iodo-5-methyl-;2-Fluoro-4-iodo-5-methylpyridine,95%;2-Fluoro-4-iodo-5-methylpyridine, 98%;2-Fluoro-4-iodo-5-methylpyridine≥ 99% (GC);2-Fluoro-4-iodo-5-picoline ISO 9001：2015 REACH;2-FLUORO-4-IODO-5-PICOLINE (2-FLUORO-4-IODO-5-METHYLPYRIDINE)
- CBNumber:
- CB5752355
- Molecular Formula:
- C6H5FIN
- Molecular Weight:
- 237.01
- MDL Number:
- MFCD03095297
- MOL File:
- 153034-94-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Fluoro-4-iodo-5-methylpyridine 97% | 731404 | 250mg | $31.1 |
| 2-Fluoro-4-iodo-5-methylpyridine >98.0%(GC) | F1035 | 1g | $26 |
| 2-Fluoro-4-iodo-5-methylpyridine >98.0%(GC) | F1035 | 5g | $86 |
| 2-Fluoro-4-iodo-5-methylpyridine 99+% (GC) ≥99%(GC) | 230325 | 1g | $199 |
| 2-Fluoro-4-iodo-5-methylpyridine 99+% (GC) ≥99%(GC) | 230325 | 5g | $403 |
| More product size | |||
| Melting point | 40-45℃ |
|---|---|
| Boiling point | <50 C |
| Density | 1.892±0.06 g/cm3(Predicted) |
| Flash point | >110°C |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | soluble in Methanol |
| pka | -1.53±0.18(Predicted) |
| form | Solid |
| color | Off-white |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C6H5FIN/c1-4-3-9-6(7)2-5(4)8/h2-3H,1H3 |
| InChIKey | BVKQLNXPPQEELX-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=C(C)C(I)=C1 |
| CAS DataBase Reference | 153034-94-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-22 | |||||||||
| Safety Statements | 26-36-36/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
|||||||||
| NFPA 704 |
|
2-Fluoro-4-iodo-5-picoline price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 731404 | 2-Fluoro-4-iodo-5-methylpyridine 97% | 153034-94-7 | 250mg | $31.1 | 2023-01-07 | Buy |
| TCI Chemical | F1035 | 2-Fluoro-4-iodo-5-methylpyridine >98.0%(GC) | 153034-94-7 | 1g | $26 | 2026-04-30 | Buy |
| TCI Chemical | F1035 | 2-Fluoro-4-iodo-5-methylpyridine >98.0%(GC) | 153034-94-7 | 5g | $86 | 2026-04-30 | Buy |
| Usbiological | 230325 | 2-Fluoro-4-iodo-5-methylpyridine 99+% (GC) ≥99%(GC) | 1g | $199 | 2026-06-03 | Buy | |
| Usbiological | 230325 | 2-Fluoro-4-iodo-5-methylpyridine 99+% (GC) ≥99%(GC) | 5g | $403 | 2026-06-03 | Buy |
2-Fluoro-4-iodo-5-picoline Chemical Properties,Uses,Production
Chemical Properties
crystals
Synthesis
2369-19-9
153034-94-7
The general procedure for the synthesis of 2-fluoro-4-iodo-5-methylpyridine from 2-fluoro-5-methylpyridine was as follows: diisopropylamine (92 mL) was added to tetrahydrofuran (THF, 1.2 L) under nitrogen protection and the mixture was cooled to -18 °C. A hexane solution of 2.69 M n-butyllithium (224 mL) was slowly added dropwise to this solution. After the dropwise addition was completed, the temperature of the reaction system was raised to -5 °C within 20 min under stirring and subsequently cooled to -73 °C. At this temperature, a THF solution (240 mL) of 2-fluoro-5-methylpyridine (61 g) was slowly added dropwise and the reaction was stirred at -75 °C for 3.5 hours. Subsequently, a THF solution (24 mL) of iodine (139 g) was added dropwise to the reaction solution and stirring was continued at -75 °C for 1 hour and 55 minutes. After the reaction was completed, water (220 mL) was added at the same temperature and stirred for 5 minutes. After returning the reaction system to room temperature, water (1.2 L) was added. Next, an aqueous solution (300 mL) of sodium thiosulfate pentahydrate (136 g) was added and stirred for 10 minutes. The mixture was extracted with methyl tert-butyl ether (MTBE, 1.2 L) and the organic layer was washed with saturated brine (500 mL). The combined aqueous layers were then extracted with MTBE (1 L). All organic layers were combined and dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. To the residue n-heptane was added, cooled and filtered to collect the precipitated solid. The solids were washed with n-heptane and the filtrate was cooled and filtered again to collect the precipitate. The process was repeated 5 times to finally obtain 2-fluoro-4-iodo-5-methylpyridine (109.69 g). The product was characterized by 1H-NMR (400 MHz, CDCl3) and ESI-MS to confirm the correct structure.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 18, p. 4603 - 4606
[2] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[3] Patent: US2016/46623, 2016, A1. Location in patent: Paragraph 0166-0168
2-Fluoro-4-iodo-5-picoline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from 2-Fluoro-4-iodo-5-picoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-16 | 2-Fluoro-4-iodo-5-picoline
153034-94-7
|
1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2025-11-18 | 2-Fluoro-4-iodo-5-picoline
153034-94-7
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-04-04 | 2-Fluoro-4-iodo-5-picoline
153034-94-7
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-Fluoro-4-iodo-5-picoline
153034-94-7
- $0.00
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 2-Fluoro-4-iodo-5-picoline
153034-94-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Fluoro-4-iodo-5-picoline
153034-94-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
