Ethyl 6-fluoroindole-2-carboxylate
- CAS No.
- 348-37-8
- Chemical Name:
- Ethyl 6-fluoroindole-2-carboxylate
- Synonyms
- Piperazine,4-(methylsulfonyl)-;ETHYL 6-FLUOROINDOLE-2-CARBOXYLATE;Ethyl 6-fluoro-1H-indol-2-carboxylate;2-(Ethoxycarbonyl)-6-fluoro-1H-indole;6-FLUOROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER;1H-Indole-2-carboxylic acid, 6-fluoro-, ethyl ester;6-Fluoro-1H-indole-2-carboxylic acid ethyl ester, 98%;6-fluoro-1H-Indole-2-carboxylic acid ethyl ester (9CI ACI);1H-Indole-2-carboxylic acid, 6-fluoro-, ethyl ester (9CI, ACI)
- CBNumber:
- CB5769115
- Molecular Formula:
- C11H10FNO2
- Molecular Weight:
- 207.2
- MDL Number:
- MFCD03095203
- MOL File:
- 348-37-8.mol
| Product description | Number | Pack Size | Price |
| Ethyl 6-fluoro-1H-indole-2-carboxylate AldrichCPR | PHB00185 | 1G | $87.5 |
| Ethyl6-Fluoro-1H-indole-2-carboxylate | E918358 | 50mg | $45 |
| Ethyl 6-fluoroindole-2-carboxylate | 4H23-3-X3 | 1g | $95 |
| Ethyl6-fluoro-1H-indole-2-carboxylate 95+% | 210636 | 1g | $108 |
| Ethyl6-fluoro-1H-indole-2-carboxylate 97.0% | 122419 | 1g | $149 |
| Melting point | 143 °C |
|---|---|
| Boiling point | 345.9±22.0 °C(Predicted) |
| Density | 1.291±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 14.41±0.30(Predicted) |
| form | solid |
| color | Light yellow |
| Sensitive | Light Sensitive |
| InChI | 1S/C11H10FNO2/c1-2-15-11(14)10-5-7-3-4-8(12)6-9(7)13-10/h3-6,13H,2H2,1H3 |
| InChIKey | KOLXHQLPMICACW-UHFFFAOYSA-N |
| SMILES | FC1=CC2=C(C=C1)C=C(C(OCC)=O)N2 |
| CAS DataBase Reference | 348-37-8(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| HS Code | 2933998090 |
| Storage Class | 11 - Combustible Solids |
Ethyl 6-fluoroindole-2-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHB00185 | Ethyl 6-fluoro-1H-indole-2-carboxylate AldrichCPR | 348-37-8 | 1G | $87.5 | 2025-07-31 | Buy |
| TRC | E918358 | Ethyl6-Fluoro-1H-indole-2-carboxylate | 348-37-8 | 50mg | $45 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H23-3-X3 | Ethyl 6-fluoroindole-2-carboxylate | 348-37-8 | 1g | $95 | 2021-12-16 | Buy |
| Oakwood | 210636 | Ethyl6-fluoro-1H-indole-2-carboxylate 95+% | 348-37-8 | 1g | $108 | 2021-12-16 | Buy |
| Matrix Scientific | 122419 | Ethyl6-fluoro-1H-indole-2-carboxylate 97.0% | 348-37-8 | 1g | $149 | 2021-12-16 | Buy |
Ethyl 6-fluoroindole-2-carboxylate Chemical Properties,Uses,Production
Synthesis
346-43-0
348-37-8
(3-2) Ethyl 3-(4-fluoro-2-nitrophenyl)-2-oxopropanoate (5.51 g, 21.6 mmol) obtained in Reference Example (3-1) was dissolved in a mixed solvent of ethanol and acetic acid (1:1, 84 mL, by volume). Iron powder (10.9 g, 144 mmol) was added to this solution and the mixture was subsequently heated to reflux for 3.5 hours. Upon completion of the reaction, the reaction mixture was diluted with tetrahydrofuran and filtered through diatomaceous earth to remove insoluble material. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/acetone = 15:1) to afford ethyl 6-fluoro-1H-indole-2-carboxylate (3.62 g, 81% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 8.89 (1H, br.s), 7.61 (1H, dd, J=8.8,5.5 Hz), 7.20 (1H, m), 7.09 (1H, dd, J=9.4,2.0 Hz), 6.94 (1H, dd, J=9.4,8.8,2.0 Hz). 4.41 (2H, q, J=7.0 Hz), 1.42 (3H, t, J=7.0 Hz). (9-6) Ethyl 3-(4-fluoro-2-nitrophenyl)-2-oxopropanoate (5.51 g, 21.6 mmol) obtained in Reference Example (9-5) was dissolved in a mixed solvent of ethanol and acetic acid (1:1, 84 mL, by volume). Iron powder (10.9 g, 144 mmol) was added to this solution and the mixture was subsequently heated to reflux for 3.5 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and diluted with tetrahydrofuran. Insoluble material was removed by filtration through diatomaceous earth and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/acetone=15:1) to afford ethyl 6-fluoro-1H-indole-2-carboxylate (3.62 g, 81% yield) as yellow crystalline. The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 8.89 (1H, br.s), 7.61 (1H, dd, J=8.8,5.5 Hz), 7.20 (1H, m), 7.09 (1H, dd, J=9.4,2.0 Hz), 6.94 (1H, dd, J=9.4,8.8,2.0 Hz). 4.41 (2H, q, J=7.0Hz), 1.42 (3H, t, J=7.0Hz).
References
[1] Patent: EP1764075, 2007, A1. Location in patent: Page/Page column 81-82; 91
[2] Patent: WO2006/109633, 2006, A1. Location in patent: Page/Page column 138-139
Ethyl 6-fluoroindole-2-carboxylate Preparation Products And Raw materials
Ethyl 6-fluoroindole-2-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
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| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
View Lastest Price from Ethyl 6-fluoroindole-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | Ethyl 6-fluoroindole-2-carboxylate
348-37-8
|
US $1.00 / KG | 1KG | 99% | 1kg-1000kg | Career Henan Chemical Co |
-
- Ethyl 6-fluoroindole-2-carboxylate
348-37-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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