4-Bromo-6-(1H)indazole carboxylic acid
- CAS No.
- 885520-26-3
- Chemical Name:
- 4-Bromo-6-(1H)indazole carboxylic acid
- Synonyms
- 4,7-difluoroindazole;1H-Indazole, 4,6-difluoro-;4-Bromo-6-(1H)indazole carboxylic acid
- CBNumber:
- CB5771677
- Molecular Formula:
- C7H4F2N2
- Molecular Weight:
- 154.12
- MDL Number:
- MFCD07781445
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
4-Bromo-6-(1H)indazole carboxylic acid price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC53227 | 4,6-Difluoro-1H-indazole 98% | 885520-26-3 | 100mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | PC53227 | 4,6-Difluoro-1H-indazole 98% | 885520-26-3 | 250mg | $30 | 2026-06-04 | Buy |
| Apolloscientific | PC53227 | 4,6-Difluoro-1H-indazole 98% | 885520-26-3 | 1g | $54 | 2026-06-04 | Buy |
| Apolloscientific | PC53227 | 4,6-Difluoro-1H-indazole 98% | 885520-26-3 | 5g | $260 | 2026-06-04 | Buy |
| Activate Scientific | AS43769 | 4,6-Difluoro-1H-indazole 97% | 885520-26-3 | 1g | $93 | 2026-06-04 | Buy |
4-Bromo-6-(1H)indazole carboxylic acid Chemical Properties, Uses, Production
Uses
4,6-Difluoro-1H-indazole is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.
Synthesis
58551-83-0
885520-26-3
General procedure for the synthesis of 4,6-difluoro-1H-indazoles from 2,4,6-trifluorobenzaldehyde: Step 1: Synthesis of 4,6-difluoro-1H-indazole 2,4,6-Trifluorobenzaldehyde (0.80 g, 5.0 mmol) was dissolved in 1,2-dimethoxyethane (10 mL) and potassium carbonate (1.04 g, 7.5 mmol) and O-methylhydroxylamine hydrochloride (438 mg, 5.25 mmol) were added sequentially. The reaction mixture was heated at 50 °C for 5 h. After cooling to room temperature, it was filtered and washed with dichloromethane. The filtrate was concentrated and the residue was redissolved in 1,2-dimethoxyethane (10 mL) and hydrazine (0.17 mL, 5.5 mmol) was added. The reaction mixture was heated at 100 °C for 1.5 h. Hydrazine (0.17 mL, 5.5 mmol) was added and heating was continued for 30 min. After completion of the reaction, it was cooled to room temperature, poured into water and extracted with ethyl acetate. The organic layer was washed sequentially with saturated LiCl solution and brine, dried over MgSO4 and concentrated. The residue was purified by silica gel column chromatography (eluent: 20% to 50% EtOAc/heptane) to afford 358 mg (47% yield) of 4,6-difluoro-1H-indazole as a light yellow solid. 1H NMR (DMSO-d6, 300 MHz) δ (ppm): 13.47 (br.s, 1H), 8.19 (s, 1H), 7.22 (d, J = 9.1 Hz, 1H), 6.96 (td, J = 10.0, 1.9 Hz, 1H).
References
[1] Patent: WO2013/30138, 2013, A1. Location in patent: Page/Page column 237; 238
4-Bromo-6-(1H)indazole carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-6-(1H)indazole carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3830 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3987 | 55 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3538 | 55 |
| Shanghai Devinchem Ltd | 027-65318838 13646286950 | sales@devinchem.com | China | 2983 | 58 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4906 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
