Diethyl maleate
- CAS No.
- 141-05-9
- Chemical Name:
- Diethyl maleate
- Synonyms
- DEM;Staflex DEM;ETHYL MALEATE;iethylmaleate;DIETHYL MALEATE;Diethyl malcate;DiethylMaleate>Diethylbutenedioate;Maleic acid diethyl;Diethyl Maleate 97%
- CBNumber:
- CB5772427
- Molecular Formula:
- C8H12O4
- Molecular Weight:
- 172.18
- MDL Number:
- MFCD00009191
- MOL File:
- 141-05-9.mol
| Product description | Number | Pack Size | Price |
| Diethyl maleate ≥96%, FG | W505005 | 1 unit | $59.8 |
| Diethyl maleate ≥96%, FG | W505005 | 1 unit | $59.8 |
| Diethyl maleate 97% | D97703 | 5g | $37.5 |
| Diethyl maleate analytical standard | 07553 | 1ml | $85.6 |
| Diethyl Maleate >90.0%(GC) | M0010 | 25mL | $18 |
| More product size | |||
| Melting point | -10 °C (lit.) |
|---|---|
| Boiling point | 225 °C (lit.) |
| Density | 1.064 g/mL at 25 °C (lit.) |
| vapor density | 5.93 (vs air) |
| vapor pressure | 1 mm Hg ( 14 °C) |
| refractive index |
n |
| Flash point | 200 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 14mg/l |
| form | Liquid |
| color | Clear |
| Odor | at 100.00 %. fruity banana citrus |
| Odor Type | fruity |
| biological source | synthetic |
| Water Solubility | insoluble |
| Merck | 14,3123 |
| BRN | 1100825 |
| Dielectric constant | 8.6（23℃） |
| Stability | Stable. Combustible. Incompatible with oxidizing agents, bases, acids, reducing agents. |
| Major Application |
cleaning products cosmetics food and beverages personal care |
| InChI | 1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3/b6-5- |
| InChIKey | IEPRKVQEAMIZSS-AATRIKPKSA-N |
| SMILES | CCOC(=O)\C=C/C(=O)OCC |
| LogP | 2.2 |
| Indirect Additives used in Food Contact Substances | ETHYL MALEATE |
| CAS DataBase Reference | 141-05-9(CAS DataBase Reference) |
| FDA UNII | G81WQB56OL |
| NIST Chemistry Reference | 2-Butenedioic acid (Z)-, diethyl ester(141-05-9) |
| EPA Substance Registry System | 2-Butenedioic acid (2Z)-, 1,4-diethyl ester (141-05-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319-H412 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-43-52/53 | |||||||||
| Safety Statements | 26-36/37-37-24-24/25 | |||||||||
| RIDADR | 3334 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | ON1225000 | |||||||||
| Autoignition Temperature | 662 °F | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29171990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Aquatic Chronic 3 Eye Irrit. 2 Skin Sens. 1 |
|||||||||
| Toxicity | LD50 orally in rats: 0.30 g/kg (Smyth) | |||||||||
| NFPA 704 |
|
Diethyl maleate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W505005 | Diethyl maleate ≥96%, FG | 141-05-9 | 1 unit | $59.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | W505005 | Diethyl maleate ≥96%, FG | 141-05-9 | 1 unit | $59.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | D97703 | Diethyl maleate 97% | 141-05-9 | 5g | $37.5 | 2025-07-31 | Buy |
| Sigma-Aldrich | 07553 | Diethyl maleate analytical standard | 141-05-9 | 1ml | $85.6 | 2022-05-15 | Buy |
| TCI Chemical | M0010 | Diethyl Maleate >90.0%(GC) | 141-05-9 | 25mL | $18 | 2025-07-31 | Buy |
Diethyl maleate Chemical Properties,Uses,Production
Chemical Properties
Diethyl maleate is a colorless clear liquid between the temperatures of -10°C (pour point) and 225°C (boiling point). Insoluble in water, soluble in ethanol and ether. its odor type is fruity and its odor at 100% is described as "fruity bananacitrus". It is prohibited by lFRA and theEU because of sensitization and is notused anymore as fragrance.
Occurrence
Has apparently not been reported to occur in nature.
Uses
Diethyl maleate can be used for the preparation of organophosphorus insecticide malathion. It is unsaturated polyester resins that are used in applications, such as reinforced glass fiber for boats, piping, bathtubs, roof panels, etc., and as protective coatings, finishes, and lacquers.
Uses
Diethyl Maleate is used as a reagent in the synthesis of several organic compounds including that of polyaspartic acid ester based polyurea coatings. It was found to inhibit MCA and TPA transformed cell growth via modulation of glutathione, mitogen-activated protein kinase and cancer pathways.
Definition
ChEBI: Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10℃) with boiling point 220℃ at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis. It has a role as a glutathione depleting agent. It is a maleate ester and an ethyl ester. It derives from an ethanol.
Preparation
Diethyl maleate is synthesized by the direct esterification of maleic anhydride and ethanol in the presence of sulfuric acid. Esterification is a commonly used reaction in organic synthesis.
General Description
Diethyl maleate is reported to occur in the cabernet sauvignon wine.
Synthesis
5g maleic anhydride, 12g dehydrated alcohol, 0.3g acid zeolite, 15ml benzene are added to the reaction vessel, install water trap, reflux condensing tube, and thermometer on the reaction vessel, reflux water-dividing is carried out in heating, reaction reacts 30min again after occurring without the globule, stops heating, after normal temperature cooling 30min, release water layer, reaction solution washes with water, distill after drying, first steam front-end volatiles, the cut regathering 216 ~ 220°C is product Diethyl maleate.
Metabolism
α/β-Unsaturated compounds, such as diethyl maleate, react enzymically with gluta thione. The reaction has been demonstrated in fractions of rat liver (Boyland & Chasseaud, 1967) and avian liver (Wit & Snel, 1968). The enzyme differs from other known S-alkyl, S-aryl and S- epoxide transferase enzymes responsible for glutathione-conjugate formation (Boyland & Chasseaud, 1967). Diethyl maleate, administered parenterally to rats, reduced the hepatic glutathione content (Boyland & Chasseaud, 1970; Varga, Fischer & Szily, 1974). The latter workers also showed that diethyl maleate pretreatment of rats inhibited the glutathione conjugation of subsequently-adminis tered bromsulphthalein.
Diethyl maleate Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Weifang Integratechem Co., Ltd. | +86-13026568913 +86-13026568913 | info@integratechem.com | China | 293 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 6011 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5242 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21599 | 55 |
Related articles
- Preparation and Biological Activity of Diethyl maleate
- Diethyl maleate can be prepared by the esterification of maleic anhydride with ethanol in the presence of sulfuric acid.
- Dec 30，2025
View Lastest Price from Diethyl maleate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-01-23 | Diethyl maleate
141-05-9
|
US $0.00 / kg | 1kg | 98%min | 20 tons | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2026-01-16 | Diethylmaleate
141-05-9
|
US $40.00-73.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2025-09-25 | Diethyl maleate
141-05-9
|
US $5.00-2.40 / KG | 1KG | 99% | 100 ton/month | Henan Fengda Chemical Co., Ltd |
-
- Diethyl maleate
141-05-9
- US $0.00 / kg
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Diethylmaleate
141-05-9
- US $40.00-73.00 / mg
- TargetMol Chemicals Inc.
-
- Diethyl maleate
141-05-9
- US $5.00-2.40 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
141-05-9(Diethyl maleate)Related Search:
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