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2-Bromo-5-thiazolecarboxylic acid

2-Bromo-5-thiazolecarboxylic acid structure

CAS No.: 54045-76-0

Chemical Name:: 2-Bromo-5-thiazolecarboxylic acid

Synonyms: RARECHEM AL BE 1435;2-BROMOTHIAZOLE-5-CARBOXYLIC ACID;2-BROMO-5-THIAZOLECARBOXYLIC ACID;2-BROMOTHAIZOLE-5-CARBOXYLIC ACID;2-BROMO-5-THLAZOLECARBOXYLIC ACID;5-Thiazolecarboxylicacid, 2-broMo-;2-Bromothiazole-5-carboxylicacid,97%;2-Bromothiazole-5-carboxylic acid 97%;2-Bromothiazole-5-carboxylic Acid >2-BROMO-1,3-THIAZOLE-5-CARBOXYLIC ACID

CBNumber:: CB5780794

Molecular Formula:: C4H2BrNO2S

Molecular Weight:: 208.03

MDL Number:: MFCD04115730

MOL File:: 54045-76-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:53

Product description	Number	Pack Size	Price
2-Bromothiazole-5-carboxylic acid 97%	642487	1g	$75
2-Bromothiazole-5-carboxylic acid 97%	642487	5g	$125
2-Bromothiazole-5-carboxylic Acid >97.0%(GC)(T)	B4329	1g	$49
2-Bromothiazole-5-carboxylic Acid >97.0%(GC)(T)	B4329	5g	$196
2-Bromothiazole-5-carboxylic acid	B688210	1g	$120
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2-Bromo-5-thiazolecarboxylic acid Properties

Melting point	182 °C (dec.)
Boiling point	350.0±15.0 °C(Predicted)
Density	2.062±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	2.52±0.10(Predicted)
form	Crystalline Powder
color	White to off-white
InChI	InChI=1S/C4H2BrNO2S/c5-4-6-1-2(9-4)3(7)8/h1H,(H,7,8)
InChIKey	BESGTWHUMYHYEQ-UHFFFAOYSA-N
SMILES	S1C(C(O)=O)=CN=C1Br
CAS DataBase Reference	54045-76-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317-H315-H319-H335

Precautionary statements

P280-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

Hazard Note

Irritant

HS Code

29341000

NFPA 704

	1
2		0

2-Bromo-5-thiazolecarboxylic acid price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	642487	2-Bromothiazole-5-carboxylic acid 97%	54045-76-0	1g	$75	2023-06-20	Buy
Sigma-Aldrich	642487	2-Bromothiazole-5-carboxylic acid 97%	54045-76-0	5g	$125	2023-06-20	Buy
TCI Chemical	B4329	2-Bromothiazole-5-carboxylic Acid >97.0%(GC)(T)	54045-76-0	1g	$49	2025-07-31	Buy
TCI Chemical	B4329	2-Bromothiazole-5-carboxylic Acid >97.0%(GC)(T)	54045-76-0	5g	$196	2025-07-31	Buy
TRC	B688210	2-Bromothiazole-5-carboxylic acid	54045-76-0	1g	$120	2021-12-16	Buy

Product number	Packaging	Price	Buy
642487	1g	$75	Buy
642487	5g	$125	Buy
B4329	1g	$49	Buy
B4329	5g	$196	Buy
B688210	1g	$120	Buy

2-Bromo-5-thiazolecarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

White to brown solid

Uses

2-Bromothiazole-5-carboxylic acid is used as a reagent to synthesize azole-based protein kinase B inhibitors, some of which have anti-cancer properties.

Synthesis

41731-83-3

54045-76-0

General procedure for the synthesis of 2-bromothiazole-5-carboxylic acid from ethyl 2-bromothiazole-5-carboxylate: an aqueous solution (100 mL) of sodium hydroxide (4.1 g, 102 mmol) was added slowly and dropwise at 0 °C to a solution of tetrahydrofuran (THF, 100 mL) of ethyl 2-bromothiazole-5-carboxylate (20 g, 84.7 mmol). The reaction mixture was stirred continuously at 10 °C for 1 hour. Subsequently, the reaction mixture was neutralized with 6 M hydrochloric acid and extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-bromothiazole-5-carboxylic acid (17.7 g, 100% yield) as a yellow solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6) with chemical shift δ 8.21 (s, 1H).

References

[1] Patent: WO2015/116663, 2015, A1. Location in patent: Paragraph 0103
[2] Patent: US2011/92475, 2011, A1. Location in patent: Page/Page column 14
[3] Helvetica Chimica Acta, 1954, vol. 37, p. 2057,2064
[4] Patent: US6066639, 2000, A

2-Bromo-5-thiazolecarboxylic acid Preparation Products And Raw materials

Raw materials

Ethyl 2-bromothiazole-5-carboxylate Tetrahydrofuran Water Sodium hydroxide

Preparation Products

2-Bromo-5-thiazolecarboxylic acid Suppliers

Global( 279)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI SAGACHEM CO., LTD.	+86-02168404722 +86-13816115801	david_si@shjlchem.com	China	211	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2953	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
SHANGHAI SAGACHEM CO., LTD.	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Jinan Finer Chemical Co., Ltd	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 2-Bromo-5-thiazolecarboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-25	2-Bromo-5-thiazolecarboxylic acid 54045-76-0	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2021-07-13	2-Bromo-5-thiazolecarboxylic acid 54045-76-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	2-Bromo-5-thiazolecarboxylic acid 54045-76-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

2-Bromo-5-thiazolecarboxylic acid
54045-76-0
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

2-Bromo-5-thiazolecarboxylic acid
54045-76-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Bromo-5-thiazolecarboxylic acid
54045-76-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Bromo-5-thiazolecarboxylic acid Spectrum

2-Bromo-5-thiazolecarboxylic acid(54045-76-0)¹HNMR

54045-76-0(2-Bromo-5-thiazolecarboxylic acid)Related Search:

2-Methyl-4-isothiazolin-3-one 4-Bromobenzoic acid 2,2'-Dithiobis(benzothiazole) Methyl 2-bromobenzoate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)

Benzothiazole Ethyl 2-(Chlorosulfonyl)acetate 4-Bromomethylbenzoic acid 2-Bromothiazole Fosthiazate

2-BROMO-4-THIAZOLECARBOXYLIC ACID Ascoric Acid Bromine CARBOXYLIC ACID 2-Bromo-5-thiazolecarboxylic acid

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2-Bromo-1,3-thiazole-5-carboxylic acid 97% 2-BROMO-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-BROMO-5-THIAZOLECARBOXYLIC ACID 2-BROMOTHIAZOLE-5-CARBOXYLIC ACID RARECHEM AL BE 1435 2-BROMO-5-THLAZOLECARBOXYLIC ACID 2-BROMOTHAIZOLE-5-CARBOXYLIC ACID 2-Bromothiazole-5-carboxylicacid,97% 2-Bromothiazole-5-carboxylic acid 97% 2-Bromo-1,3-thiazole-5-carboxylicacid97% 5-Thiazolecarboxylicacid, 2-broMo- 2-Bromothiazole-5-carboxylic Acid > 54045-76-0 54045-79-0 4045-76-0 C4HBrNO2S Thiazoles Halogenated Heterocycles Heterocyclic Building Blocks Building Blocks Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks ThiazolesHeterocyclic Building Blocks Carboxylic Acids Thiazoles, Isothiazoles & Benzothiazoles Carboxylic Acids Thiazoles, Isothiazoles &Benzothiazoles Organic acids Building Blocks Thiazole blocks Bromides Carboxes Thiazoles