ChemicalBook >> CAS DataBase List >>1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-
1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-
![1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- Structure](CAS/20200611/GIF/1623416-31-8.gif)
- CAS No.
- 1623416-31-8
- Chemical Name:
- 1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-
- Synonyms
- AG-636;1-Methyl-5-(2'-methyl-[1,1'-biphenyl]-4-yl)-1H-benzo[d][1,2,3]triazole-7-carboxylic acid;AG-636, 10 mM in DMSO;1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-;inhibit,oral,AG 636,AG-636,reversible,DHODH,anticancer,AG636,Inhibitor,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis
- CBNumber:
- CB58145445
- Molecular Formula:
- C21H17N3O2
- Molecular Weight:
- 343.38
- MDL Number:
- MFCD33023454
- MOL File:
- 1623416-31-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-30 16:52:23
| Product description | Number | Pack Size | Price |
| AG-636 ≥98% | 36122 | 1mg | $62 |
| AG-636 ≥98% | 36122 | 5mg | $244 |
| AG-636 ≥98% | 36122 | 10mg | $425 |
| AG-636 ≥98% | 36122 | 25mg | $605 |
| AG-636 | YPC41631 | 25mg | $1382.75 |
| Boiling point | 619.3±43.0 °C(Predicted) |
|---|---|
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 31.25 mg/mL (91.01 mM; Need ultrasonic) |
| form | A solid |
| pka | 2.73±0.10(Predicted) |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36122 | AG-636 ≥98% | 1623416-31-8 | 1mg | $62 | 2026-04-30 | Buy |
| Cayman Chemical | 36122 | AG-636 ≥98% | 1623416-31-8 | 5mg | $244 | 2026-04-30 | Buy |
| Cayman Chemical | 36122 | AG-636 ≥98% | 1623416-31-8 | 10mg | $425 | 2026-04-30 | Buy |
| Cayman Chemical | 36122 | AG-636 ≥98% | 1623416-31-8 | 25mg | $605 | 2026-04-30 | Buy |
| Biosynth | YPC41631 | AG-636 | 1623416-31-8 | 25mg | $1382.75 | 2026-06-05 | Buy |
1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- Chemical Properties,Uses,Production
Uses
AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects[1].
in vivo
AG-636 (10-100 mg/kg ; oral gavage; twice daily; for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model[1].
| Animal Model: | Transgenic female 6-8-week-old CB17/Icr-Prkdcscid/IcrIcoCrl (CB17 SCID) mice injected with OCILY19 cells[1] |
| Dosage: | 10 mg/kg, 30 mg/kg, or 100 mg/kg |
| Administration: | Oral gavage; twice daily; for 14 days |
| Result: | Resulted in robust tumor growth inhibition in xenograft lymphoma tumor models. |
References
[1] Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19(12):2502-2515. DOI:10.1158/1535-7163.MCT-20-0550
1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- Suppliers
Global( 45)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9932 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
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1623416-31-8(1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-)Related Search:
1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-
inhibit,oral,AG 636,AG-636,reversible,DHODH,anticancer,AG636,Inhibitor,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis
AG-636, 10 mM in DMSO
1-Methyl-5-(2'-methyl-[1,1'-biphenyl]-4-yl)-1H-benzo[d][1,2,3]triazole-7-carboxylic acid
AG-636
1623416-31-8
