PACA >=98% (HPLC)
- CAS No.
- 1431724-30-9
- Chemical Name:
- PACA >=98% (HPLC)
- Synonyms
- PACA >=98% (HPLC);Propargyl caffeamide;N-Propargyl Caffeamide;2-Propenamide, 3-(3,4-dihydroxyphenyl)-N-2-propyn-1-yl-;(E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn- 1-yl)acrylamide
- CBNumber:
- CB58378731
- Molecular Formula:
- C12H11NO3
- Molecular Weight:
- 217.22
- MDL Number:
- MFCD29079015
- MOL File:
- 1431724-30-9.mol
PACA >=98% (HPLC) Chemical Properties,Uses,Production
Description
PACA, also known as N-Propargyl Caffeamide, potentiates NGF-induced neurite outgrowth and attenuates 6-hydroxydopamine neurotoxicity in neuronal culture. Insufficient production of nerve growth factor (NGF) is implicated in Parkinson's disease (PD).
Uses
PACA is an enhancer of nerve growth factor-induced neurite outgrowth, enhancing nerve growth factor (NGF)-induced neurite outgrowth and attenuating 6-hydroxydopamine (6-OHDA)-induced toxicity by activating the Nrf2/HO-1 pathway. PACA has neuroprotective and neurogenic activities. PACA can be used to improve dopaminergic neuron loss and motor dysfunction in MPTP mouse models of Parkinson's disease and MPP+-induced neurons[1][2].
References
[1] Luo D, et al. N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP+-Induced Neurons via Promoting the Conversion of proNGF to NGF. Mol Neurobiol. 2018 Mar;55(3):2258-2267. DOI:10.1007/s12035-017-0486-6
[2] Yang C, et al. N-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway. ACS Chem Neurosci. 2015 Sep 16;6(9):1560-9. DOI:10.1021/acschemneuro.5b00115
PACA >=98% (HPLC) Preparation Products And Raw materials
Raw materials
Preparation Products
PACA >=98% (HPLC) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38665 | 58 | |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2028 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 1266 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |