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GMB-475

GMB-475 Structure
GMB-475 structure
CAS No.
2490599-18-1
Chemical Name:
GMB-475
Synonyms
GMB-475;GMB-475 ，S8888;GMB-475, 10 mM in DMSO;Bcr-Abl,GMB-475,PROTACs,GMB 475,Apoptosis,Inhibitor,inhibit,GMB475;(2S)-1-((R)-3,3-dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CBNumber:
CB58379743
Molecular Formula:
C43H46F3N7O7S
Molecular Weight:
861.93
MDL Number:
MOL File:
2490599-18-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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GMB-475 Properties

Boiling point 1029.7±65.0 °C(Predicted)
Density 1.337±0.06 g/cm3(Predicted)
solubility DMSO:145.4(Max Conc. mg/mL);168.69(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);58.01(Max Conc. mM)
form Solid
pka 13.50±0.46(Predicted)
color Light yellow to yellow
InChIKey ONDVWISBMHHLGZ-XAYQSWBHNA-N
SMILES C(N1C[C@H](O)C[C@H]1C(=O)NCC1C=CC(C2=C(N=CS2)C)=CC=1)(=O)[C@H](C(C)(C)C)NC(=O)COCCOC1C=CC(C2=NC=NC(NC3C=CC(OC(F)(F)F)=CC=3)=C2)=CC=1 |&1:3,6,24,r|

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

GMB-475 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 40463 GMB 475 ≥98% 2490599-18-1 5mg $82 2026-04-30 Buy
Cayman Chemical 40463 GMB 475 ≥98% 2490599-18-1 10mg $156 2026-04-30 Buy
Cayman Chemical 40463 GMB 475 ≥98% 2490599-18-1 25mg $367 2026-04-30 Buy
Cayman Chemical 40463 GMB 475 ≥98% 2490599-18-1 50mg $611 2026-04-30 Buy
ChemScene CS-0100935 GMB-475 ≥98% 2490599-18-1 5mg $43 2026-06-04 Buy
Product number Packaging Price Buy
40463 5mg $82 Buy
40463 10mg $156 Buy
40463 25mg $367 Buy
40463 50mg $611 Buy
CS-0100935 5mg $43 Buy

GMB-475 Chemical Properties, Uses, Production

Description

GMB-475 acts as a degrader of BCR-ABL 1 tyrosine kinase and as a recruiter of the E3 ligase Von Hippel Lindau (VHL) resulting in ubiquitination and subsequent degradation of oncogenic fusion proteins.

Uses

GMB-475 is a potent BCR-ABL1 PROTAC based on Von Hippel-Lindau (VHL). GMB-475 targets the nutmeg pocket of ABL1 in an ectopic manner and degrades BCR-ABL1 protein through the ubiquitin proteasome pathway. GMB-475 inhibits the proliferation of human K562 cells and mouse Ba/F3 cells, and is used for the study of chronic myeloid leukemia. (Blue: VHL ligand (HY-125845); Black: Linker; Pink: BCR-ABL1 ligand (HY-11007))[1][2].

Biological Activity

GMB-475, a BCR-ABL1 Inhibitor Based on PROTAC, Has the Potential to Overcome BCR-ABL1-Dependent Drug Resistance. In both human CML K562 cells and murine Ba/F3 cells expressing BCR-ABL1, GMB-475 induces rapid proteasomal degradation and inhibition of downstream biomarkers. Notably, GMB-475 inhibits the proliferation of certain clinically relevant BCR-ABL1 kinase domain point mutants. GMB-475 reduces viability and increases apoptosis in primary chronic myeloid leukemia CD34+ cells, with no effect on healthy CD34+ cells. Furthermore, GMB-475 degrades BCR-ABL1 and reduces cell viability in primary chronic myeloid leukemia stem cells.

in vivo

GMB-475 (5 mg/kg; once every two days; 10 days; i.p.) improves chronic myeloid leukemia in mice with BCR::ABL1 mutant by targeted degradation of BCR-ABL1b and combined with dasatinib (HY-10181)[2].

Animal Model:8-week-old Balb/c mice were injected with Ba/F3-MG-p210-Luc cells via tail vein to establish a chronic myeloid leukemia (CML) mouse model[2].
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.); once every two days; 10 days
Result:Showed a trend of reducing the tumor burden and prolonging the survival of the CML mouse model.

IC 50

STAT5; VHL; Bcr-Abl

storage

Store at -20°C

References

[1] Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation. Cancer Res. 2019 Sep 15;79(18):4744-4753. DOI:10.1158/0008-5472.CAN-19-1236
[2] Ye W, et al. The proteolysis targeting chimera GMB-475 combined with dasatinib for the treatment of chronic myeloid leukemia with BCR::ABL1 mutants. Front Pharmacol. 2022 Oct 3;13:931772. DOI:10.3389/fphar.2022.931772

GMB-475 Preparation Products And Raw materials

Raw materials

Preparation Products

GMB-475 Suppliers

Global Suppliers ( 72)
Supplier Tel Email Country ProdList Advantage
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618 sales@adobechem.com China 1250 50
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4058 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 4975 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2969 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
Supplier Advantage
Shanghai YuanQi Biotechnology Co., Ltd. 50
Changzhou Chenhong Biotechnology Co., Ltd. 58
Bide Pharmatech Ltd. 60
Shanghaizehan biopharma technology co., Ltd. 55
ShangHai Angti Biotechnology Co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58

View Latest Price from GMB-475 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GMB-475 pictures 2026-07-27 GMB-475
2490599-18-1
 $45.00-172.00 99.89% 10g TargetMol Chemicals Inc.
GMB-475 pictures 2026-07-24 GMB-475
2490599-18-1
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
GMB-475 pictures 2025-03-16 GMB-475
2490599-18-1
 1mg 98% 100G Hubei Chuchang Biotech Co., Ltd.
  • GMB-475 pictures
  • GMB-475
    2490599-18-1
  • $45.00-172.00
  • 99.89%
  • TargetMol Chemicals Inc.
  • GMB-475 pictures
  • GMB-475
    2490599-18-1
  • $0.00
  • 98%
  • Shaanxi Dideu New Materials Co. Ltd
  • GMB-475 pictures
  • GMB-475
    2490599-18-1
  • 98%
  • Hubei Chuchang Biotech Co., Ltd.

GMB-475 Spectrum

GMB-475(2490599-18-1)1HNMR

2490599-18-1 (GMB-475) Related Search:

(2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[4-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]phenoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide Gefitinib-based PROTAC 3 (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-N-(2-(2-(4-formylphenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide VH032-O-Ph-PEG1-NH2 (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
E3 ligase Ligand-Linker Conjugates 6 Free Base

1of2

(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide GMB-475 Bcr-Abl,GMB-475,PROTACs,GMB 475,Apoptosis,Inhibitor,inhibit,GMB475 GMB-475, 10 mM in DMSO (2S)-1-((R)-3,3-dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide GMB-475 ，S8888 2490599-18-1 1862425-99-9 C43H46F3N7O7S