Tetramethylsilane
- CAS No.
- 75-76-3
- Chemical Name:
- Tetramethylsilane
- Synonyms
- TMS;4MS;Silane, tetramethyl-;(CH3)4Si;Si(CH3)4;Trialkylsilane;Tetramethylsilicane;TetraMethylsilane, ACS reagent, NMR grade;CT2050;DKSI045
- CBNumber:
- CB5854242
- Molecular Formula:
- C4H12Si
- Molecular Weight:
- 88.22
- MDL Number:
- MFCD00008274
- MOL File:
- 75-76-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tetramethylsilane solution NMR reference standard, 12% in chloroform, NMR tube size 5mm × 8in. | 551333 | 1ea | $244 |
| Tetramethylsilane electronic grade, ≥99.99% trace metals basis | 523771 | 100ml | $291 |
| Tetramethylsilane for the calibration of NMR spectra for NMR spectroscopy MagniSolv? | 1.08183 | 100mL | $236 |
| Tetramethylsilane [for NMR] >99.0%(GC) | T0154 | 25mL | $43 |
| Tetramethylsilane [for NMR] >99.0%(GC) | T0154 | 100mL | $118 |
| More product size | |||
| Melting point | -99 °C (lit.) |
|---|---|
| Boiling point | 26-28 °C (lit.) |
| Density | 0.648 g/mL at 25 °C (lit.) |
| vapor pressure | 11.66 psi ( 20 °C) |
| refractive index |
n |
| RTECS | VV5706000 |
| Flash point | −17 °F |
| storage temp. | 2-8°C |
| solubility | 0.02g/l |
| form | liquid |
| color | colorless |
| Specific Gravity | 0.648 |
| explosive limit | 1.0-37.9%(V) |
| Water Solubility | 0.02 G/L (25 ºC) |
| Specific Heat Capacity | Cp(liquid): 2.31 J/(g·K); Cp(gas): 1.63 J/(g·K), at 25℃ |
| Hydrolytic Sensitivity | 1: no significant reaction with aqueous systems |
| Merck | 14,9229 |
| BRN | 1696908 |
| Henry's Law Constant | 2.3×10-6 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Dielectric constant | 1.9199999999999999 |
| Stability | Stable. Highly flammable - readily forms explosive mixtures with air. Note the boiling point close to room temperature, the low flash point and high vapour pressure. Incompatible with oxidizing agents. Refrigerate before opening. |
| InChI | 1S/C4H12Si/c1-5(2,3)4/h1-4H3 |
| InChIKey | CZDYPVPMEAXLPK-UHFFFAOYSA-N |
| SMILES | C[Si](C)(C)C |
| CAS DataBase Reference | 75-76-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 41Y0RBG14Q |
| NIST Chemistry Reference | Silane, tetramethyl-(75-76-3) |
| EPA Substance Registry System | Tetramethylsilane (75-76-3) |
| UNSPSC Code | 12352103 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H224 | |||||||||
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235 | |||||||||
| Hazard Codes | Xn,F+ | |||||||||
| Risk Statements | 12-48/20/22-40-38-22 | |||||||||
| Safety Statements | 36-45-33-3/7-16-9-36/37 | |||||||||
| RIDADR | UN 2749 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| Autoignition Temperature | 842 °F | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2931 90 00 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | I | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Flam. Liq. 1 | |||||||||
| Hazardous Substances Data | 75-76-3(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Tetramethylsilane price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 551333 | Tetramethylsilane solution NMR reference standard, 12% in chloroform, NMR tube size 5mm × 8in. | 75-76-3 | 1ea | $244 | 2026-04-30 | Buy |
| Sigma-Aldrich | 523771 | Tetramethylsilane electronic grade, ≥99.99% trace metals basis | 75-76-3 | 100ml | $291 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1.08183 | Tetramethylsilane for the calibration of NMR spectra for NMR spectroscopy MagniSolv? | 75-76-3 | 100mL | $236 | 2026-04-30 | Buy |
| TCI Chemical | T0154 | Tetramethylsilane [for NMR] >99.0%(GC) | 75-76-3 | 25mL | $43 | 2026-04-30 | Buy |
| TCI Chemical | T0154 | Tetramethylsilane [for NMR] >99.0%(GC) | 75-76-3 | 100mL | $118 | 2026-04-30 | Buy |
Tetramethylsilane Chemical Properties,Uses,Production
Chemical Properties
Tetramethylsilane (TMS) is the simplest tetraalkylsilane. It is a colorless, highly volatile liquid with a characteristic organometallic odor. TMS is chemically stable, insoluble in water, and soluble in most organic solvents.
In nuclear magnetic resonance (NMR) spectroscopy, TMS is widely used as an internal standard for chemical shift measurements. Chemical shift is a relative value and is generally referenced to TMS, whose chemical shift is defined as 0 ppm. The protons in TMS experience a strong shielding effect, requiring a relatively high external magnetic field to achieve resonance. As a result, few compounds exhibit signals at a higher field than TMS, making it an ideal reference standard for NMR analysis.
Uses
Tetramethylsilane is used as a building block in organometallic chemistry. It acts as a by-product in the production of methyl chlorosilanes. Also, it serves as a precursor to silicon dioxide or silicon carbide. It is used as internal reference standard for the calibration of chemical sift for 1, 13 and 29 NMR spectroscopy. In addition, it is used as an aviation fuel.
Uses
NMR reference standard. In semiconductor applications (chemical vapor deposition). Tetramethylsilane (TMS) is used as a chemical shift reference for proton, carbon-13, and silicon-29 analysis in organic solvents and is given 0 as its chemical shift position.
Definition
ChEBI: Tetramethylsilane is an organosilicon compound that is silane in which the hydrogens have been replaced by methyl groups.
Preparation
At present, the synthesis method of Tetramethylsilane mainly comprises two methods, namely, tetrachlorosilane or tetraethoxysilane is reacted with methyl magnesium iodide to prepare the tetramethylsilane. The second one is prepared by reacting chloromethane and silicon powder in the presence of copper catalyst and then carrying out fine fractionation.
General Description
Tetramethylsilane appears as a colorless, mildly acidic volatile liquid. A serious fire hazard. Mildly toxic by ingestion. Emits acrid smoke and fumes when heated to high temperatures. Less dense than water and insoluble in water, but soluble in most organic solvents. Used as an aviation fuel and as an internal standard for nmr analytical instruments.
Air & Water Reactions
Highly flammable. Tetramethylsilane is insoluble in water.
Reactivity Profile
Hydrides, such as Tetramethylsilane, are reducing agents and react rapidly and dangerously with oxygen and with other oxidizing agents, even weak ones. Thus, they are likely to ignite on contact with alcohols. Hydrides are incompatible with acids, alcohols, amines, and aldehydes.
Hazard
Flammable, high fire risk.
Health Hazard
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Purification Methods
Distil it from conc H2SO4 (after shaking with it) or LiAlH4, through a 5ft vacuum-jacketed column packed with glass helices into an ice-cooled condenser, then percolate it through silica gel to remove traces of halide. [Beilstein 4 IV 3875.]
Toxics Screening Level
Tetramethysilane had an ITSL of 1300 μg/m3 annual average.
Tetramethylsilane Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zhuangming Biopharma Co., Ltd. | inquiry@zmsilane.com | China | 725 | 58 | |
| Jiangsu Vcan Advanced Material Co., Ltd. | +86-17306299870 +86-18652789875 | vcanam@vcanam.com | China | 51 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Kingfirst chemical (nanjing) co.,ltd | 86-25-84522992 | marketing@kingfirstchem.com | CHINA | 95 | 58 |
| Hubei Co-Formula Material Tech Co., Ltd. | +86-27-84459282 | sales@cfmats.com | CHINA | 882 | 58 |
| BEYOND INDUSTRIES (CHINA) LIMITED | +86-21-52699951; +8613917686115 | sales@beyondindustriesgroup.com | China | 697 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5597 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9631 | 58 |
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View Lastest Price from Tetramethylsilane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-15 | Tetramethylsilane
75-76-3
|
$1.10 | 1g | 99.0% Min | 100 Tons | Shaanxi Didu New Materials Co. Ltd | |
 |
2019-07-06 | Tetramethylsilane
75-76-3
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Tetramethylsilane
75-76-3
- $1.10
- 99.0% Min
- Shaanxi Didu New Materials Co. Ltd
-
- Tetramethylsilane
75-76-3
- $1.00
- 99%
- Career Henan Chemical Co
