N-(2-hydroxyethyl)acetoacetamide
- CAS No.
- 24309-97-5
- Chemical Name:
- N-(2-hydroxyethyl)acetoacetamide
- Synonyms
- -(N-Acetoacetylamino)ethanol;β-(N-Acetoacetylamino)ethanol;Acetoacet-N-hydroxyethylamide;beta-(N-Acetoacetylamino)ethanol;N-(2-Hydroxyethyl)-3-oxobutanamide;N-(2-Hydroxy-ethyl)-3-oxo-butyramide;N-(2-hydroxyethyl)-3-keto-butyramide;Butanamide, N-(2-hydroxyethyl)-3-oxo-
- CBNumber:
- CB5893005
- Molecular Formula:
- C6H11NO3
- Molecular Weight:
- 145.16
- MDL Number:
- MFCD00066601
- MOL File:
- 24309-97-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H226 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405 |
N-(2-hydroxyethyl)acetoacetamide price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | H41517 | N-(2-Hydroxyethyl)-3-oxobutanamide 95+% | 24309-97-5 | 100mg | $14 | 2026-05-06 | Buy |
| Synthonix | H41517 | N-(2-Hydroxyethyl)-3-oxobutanamide 95+% | 24309-97-5 | 250mg | $18 | 2026-05-06 | Buy |
| Synthonix | H41517 | N-(2-Hydroxyethyl)-3-oxobutanamide 95+% | 24309-97-5 | 1g | $20 | 2026-05-06 | Buy |
| Synthonix | H41517 | N-(2-Hydroxyethyl)-3-oxobutanamide 95+% | 24309-97-5 | 5g | $60 | 2026-05-06 | Buy |
| Synthonix | H41517 | N-(2-Hydroxyethyl)-3-oxobutanamide 95+% | 24309-97-5 | 25g | $230 | 2026-05-06 | Buy |
N-(2-hydroxyethyl)acetoacetamide Chemical Properties, Uses, Production
Chemical Properties
Yellow to brownisch solidifed melt
Uses
N-(2-Hydroxyethyl)acetoacetamide is used as intermediate for the syntheses of different organic chemicals, e.g. quinoxaline derivatives. Product Data Sheet
Synthesis
674-82-8
141-43-5
24309-97-5
General procedure for the synthesis of N-(2-hydroxyethyl)-3-oxobutanamide from bis(vinylidene) ketone and 2-aminoethanol: 23 mL (0.38 mol) of 2-aminoethanol was added slowly and dropwise to 30 g (0.36 mol) of bis(vinylidene) ketone dissolved in 300 mL of tetrahydrofuran at -5 to 0 °C. The reaction mixture was stirred at 0 °C for 1 h. Complete consumption of the feedstock was confirmed by thin layer chromatography (TLC) monitoring. Subsequently, the solvent was removed by evaporation and the residue was purified by column chromatography. Finally, 41.44 g (0.29 mol, 80% yield) of the target compound was obtained as a white solid. The product was identified by infrared spectroscopy (IR, neat, cm1) showing characteristic absorption peaks: 3273, 3097, 2973, 2938, 2880, 1710, 1646, 1558, 1494, 1465, 1420, 1362, 1347, 1312, 1297, 1215, 1190, 1166, 1052, 1038. (2H), 3.4 (4H), 2.2 (3H).
References
[1] Patent: US2013/109662, 2013, A1. Location in patent: Paragraph 0394; 0395; 0396; 0397; 0398; 0399
[2] Heterocycles, 1995, vol. 41, # 10, p. 2203 - 2220
N-(2-hydroxyethyl)acetoacetamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3994 | 55 |
| Suzhou JingTong Pharmaceutical Co., Ltd. | 13675155016 | tongtf110@sina.com | China | 963 | 55 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Shanghai SPAR pharmaceutical technology co., LTD | 021-000000 | admin@jingshipharmatech.com | China | 9918 | 58 |
| Nanjing Asfam Pharmaceutical Technology Co., Ltd. | 02558867862; 18751812725 | sales@ace-pharm.com | China | 1977 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Nanjing Ze Feng biological medicine technology Co., Ltd. | 18851912129 18851912129; | 1670471576@qq.com | China | 794 | 58 |
| Shanghai Amico Chemicals Co. LTD | 微信 18019252918 18019252918 | 1454668768@qq.com | China | 14933 | 58 |
