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ChemicalBook >> CAS DataBase List >>4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-

4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-

4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- Structure
4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- structure
CAS No.
2505339-54-6
Chemical Name:
4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-
Synonyms
BR102910;BR102910u00A0;BR102910u00A0, 10 mM in DMSO;(S)-N-[2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl]-2-(3,4-dichlorobenzyl)thiazole-4-carboxamide;4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-;FAP Inhibitor,BR102910,POP,inhibit,prolyl oligopeptidase,Inhibitor,BR-102910,BR 102910,Prolyl Endopeptidase (PREP),BR102910
CBNumber:
CB59018887
Molecular Formula:
C18H14Cl2F2N4O2S
Molecular Weight:
459.3
MDL Number:
MFCD34565708
MOL File:
2505339-54-6.mol
Last updated:2025-09-18 19:10:02
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4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- Properties

Boiling point 734.5±60.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 12.68±0.46(Predicted)
form Solid
color White to off-white

4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- Chemical Properties,Uses,Production

Uses

BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2

Biological Activity

BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2 BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner[1].

in vivo

BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner[1].

Animal Model:C57BL/6J mice (n = 5 per group)[1]
Dosage:0, 10 and 30 mg/kg
Administration:Orally, once
Result:Showed significant FAP inhibition in a dose dependent manner.

References

[1]. Hui Jin Jung, et al. Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. Bioorg Med Chem Lett. 2021 Apr 1;37:127846.

4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- Suppliers

Global( 12)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39031 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 997 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62320 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Changzhou Yourui Pharmaceutical Technology Co., Ltd 18168818882 877458914@qq.com China 3203 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
Changzhou Yourui Pharmaceutical Technology Co., Ltd 58
Sangon Biotech (Shanghai) Co.,Ltd. 58

View Lastest Price from 4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BR102910? pictures 2025-09-18 BR102910?
2505339-54-6
 US $78.00-287.00 / mg 98.45% 10g TargetMol Chemicals Inc.
  • BR102910? pictures
  • BR102910?
    2505339-54-6
  • US $78.00-287.00 / mg
  • 98.45%
  • TargetMol Chemicals Inc.
4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- (S)-N-[2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl]-2-(3,4-dichlorobenzyl)thiazole-4-carboxamide BR102910 FAP Inhibitor,BR102910,POP,inhibit,prolyl oligopeptidase,Inhibitor,BR-102910,BR 102910,Prolyl Endopeptidase (PREP),BR102910 BR102910u00A0 BR102910u00A0, 10 mM in DMSO 2505339-54-6 C18H14Cl2F2N4O2S