1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE
- CAS No.
- 193902-78-2
- Chemical Name:
- 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE
- Synonyms
- tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate;Palbociclib Impurity 102;Palbociclib Impurity SMA-7;1-Boc-4-(5-nitro-2-pyridinyl)-piperazine;1-Boc-4-(5-nitro-2-pyridyl)piperazine 97%;1-(tert-Butyloxycarbonyl)-4-(5-nitropyridin-2-yl)piperazine;4-(5-nitro-pyridin-2-yl)-piperazine-1-carboxylic
acid tert-butyl ester;1-
Boc- 4- (5- nitro- 2- pyridyl) piperazine;1-Piperazinecarboxylic acid, 4-(5-nitro-2-pyridinyl)-, 1,1-dimethylethyl ester;1-tert-Butoxycarbonyl-4-(5-nitropyrid-2-yl)piperazine, 2-(4-Boc-1-piperazinyl)-5-nitropyridine
- CBNumber:
- CB5973088
- Molecular Formula:
- C14H20N4O4
- Molecular Weight:
- 308.33
- MDL Number:
- MFCD07369779
- MOL File:
- 193902-78-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Boc-4-(5-nitro-2-pyridyl)piperazine 97% | 654191 | 10g | $263 |
| tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate | 105202 | 1.00g | $1143 |
| tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate 97.0% | B22095 | 1g | $51 |
| tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate 97.0% | B22095 | 5g | $57 |
| tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate 97.0% | B22095 | 10g | $59 |
| Melting point | 168-172 °C (lit.) |
|---|---|
| Boiling point | 468.7±45.0 °C(Predicted) |
| Density | 1.258±0.06 g/cm3(Predicted) |
| pka | 4.38±0.29(Predicted) |
| form | solid |
| InChI | 1S/C14H20N4O4/c1-14(2,3)22-13(19)17-8-6-16(7-9-17)12-5-4-11(10-15-12)18(20)21/h4-5,10H,6-9H2,1-3H3 |
| InChIKey | WWFJYZONBJARJT-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCN(CC1)c2ccc(cn2)[N+]([O-])=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 654191 | 1-Boc-4-(5-nitro-2-pyridyl)piperazine 97% | 193902-78-2 | 10g | $263 | 2023-06-20 | Buy |
| Matrix Scientific | 105202 | tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate | 193902-78-2 | 1.00g | $1143 | 2026-05-18 | Buy |
| Synthonix | B22095 | tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate 97.0% | 193902-78-2 | 1g | $51 | 2026-05-06 | Buy |
| Synthonix | B22095 | tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate 97.0% | 193902-78-2 | 5g | $57 | 2026-05-06 | Buy |
| Synthonix | B22095 | tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate 97.0% | 193902-78-2 | 10g | $59 | 2026-05-06 | Buy |
1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Chemical Properties,Uses,Production
Synthesis
4487-59-6
57260-71-6
193902-78-2
General procedure: 2-bromo-5-nitropyridine (11.39 g, 56.1 mmol), tetrabutylammonium iodide (TBAI) (1.04 g, 0.05 mmol), potassium carbonate (8.53 g, 61.7 mmol), and N-BOC-piperazine (11.5 g, 61.7 mmol) were dissolved in DMSO (100 mL) and gently heated to 50 °C. The reaction was carried out for 3 h, followed by cooling to room temperature overnight. The reaction mixture was diluted with EtOAc (200 mL), filtered to remove the salt, and the DMSO solution was obtained by evaporating the EtOAc. The solution was diluted with water to form a precipitate. The precipitate was collected by filtration, washed with water and dried under vacuum to give 1-tert-butylcarbonyl-4-(5-nitro-2-pyridyl)piperazine (16.1 g, 93%) as a light orange solid.1H NMR (400 MHz, CDCl3) δ ppm 1.47 (s, 9H), 3.55 (m, 4H), 3.75 (m, 4H), 6.55 (d, J = 9.3 Hz, 1H), 8.21 (dd, J = 9.5, 2.7 Hz, 1H), 9.03 (d, J = 2.7 Hz, 1H). 1-tert-butylcarbonyl-4-(5-nitro-2-pyridinyl)piperazine (16.0 g, 51.9 mmol) was dissolved in THF (400 mL), Raney nickel (4 g) was added, and the reaction was carried out for 5 hr under 50 psi hydrogen atmosphere. The catalyst was removed by diatomaceous earth filtration and the solvent was evaporated in vacuum to give 1-tert-butylcarbonyl-4-(5-amino-2-pyridyl)piperazine (14.5 g, 100%).1H NMR (400 MHz, CDCl3) δ ppm 1.46 (s, 9H), 3.31 (m, 6H), 3.53 (m, 4H), 6.56 (d, J = 8.8 Hz. 1H), 6.98 (dd, J = 8.8, 2.9 Hz, 1H), 7.78 (dd, J = 2.9, 0.7 Hz, 1H). m/z 279.1 (M + 1).
References
[1] Patent: US2005/182078, 2005, A1. Location in patent: Page/Page column 9; 12
[2] Tetrahedron Letters, 2011, vol. 52, # 45, p. 5905 - 5909
[3] Patent: WO2004/9587, 2004, A1. Location in patent: Page 36
[4] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0753; 0754
[5] Patent: US2004/9988, 2004, A1. Location in patent: Page/Page column 10
1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Preparation Products And Raw materials
1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Jinan Honest Pharm Co., Ltd | +8615318812076 | zpy8217@163.com | China | 286 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
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