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N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE structure

CAS No.: 42137-88-2

Chemical Name:: N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE

Synonyms: DK780;NSC 49364;LABOTEST-BB LT00455209;N,N-Bis(2-chloroethyl);N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE;N,N-Bis(-chloroethyl)-p-toluenesulfonamide;N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE;N,N-BIS(B-CHLOROETHYL)-P-TOLUENESULFONAMIDE;N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULPHONAMIDE;N-N-BIS(BETA-CHLOROETHYL)-P-TOLUENESULFONAMIDE

CBNumber:: CB6102126

Molecular Formula:: C11H15Cl2NO2S

Molecular Weight:: 296.21

MDL Number:: MFCD00018944

MOL File:: 42137-88-2.mol

Last updated:2025-07-24 18:13:48

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N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Properties

Melting point	43-50 °C
Boiling point	409.1±55.0 °C(Predicted)
Density	1.2228 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Chloroform
form	powder to crystal
pka	-8.48±0.70(Predicted)
color	White to Light yellow
BRN	2134258
InChIKey	PTVBBIMKLOMGSY-UHFFFAOYSA-N
CAS DataBase Reference	42137-88-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25

HS Code

29350090

NFPA 704

	1
2		0

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S358630	N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Aldrich^CPR	42137-88-2	1 unit	$30.7	2025-07-31	Buy
Sigma-Aldrich	S358630	N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE AldrichCPR	42137-88-2	250MG	$29.8	2024-03-01	Buy
TCI Chemical	B4059	N,N-Bis(2-chloroethyl)-p-toluenesulfonamide >98.0%(HPLC)(N)	42137-88-2	5g	$77	2025-07-31	Buy
TCI Chemical	B4059	N,N-Bis(2-chloroethyl)-p-toluenesulfonamide >98.0%(HPLC)(N)	42137-88-2	25g	$270	2025-07-31	Buy
TRC	B419010	N,N-Bis(2-chloroethyl)-p-toluenesulfonamide,TechnicalGrade90%	42137-88-2	1g	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
S358630	1 unit	$30.7	Buy
S358630	250MG	$29.8	Buy
B4059	5g	$77	Buy
B4059	25g	$270	Buy
B419010	1g	$50	Buy

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Chemical Properties,Uses,Production

Chemical Properties

GREY TO GREY-BROWN POWDER

Uses

N,N-Bis(2-chloroethyl)-p-toluenesulfonaMide can be used as an intermediate used in the process for preparation of Cetirizine (C281100).

Synthesis

821-48-7

98-59-9

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE

42137-88-2

Bis(2-chloroethyl)amine hydrochloride (25.2 g, Tokyo Chemical Industry CO., LTD.) was suspended in dichloromethane (280 mL) and the suspension was cooled to 0 °C. Pyridine (24 mL) and p-toluenesulfonyl chloride (28.3 g) were added sequentially under stirring, followed by stirring the reaction mixture for 4 hours at room temperature. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution was added to the mixture for neutralization, and then the organic phase was extracted with dichloromethane. The organic layer was washed sequentially with 1N aqueous hydrochloric acid and deionized water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by silica gel column chromatography with the eluent being hexane-ethyl acetate in different ratios (15:1 to 5:1) to afford N,N-bis(2-chloroethyl)-4-methylbenzenesulfonamide (30.0 g, 71% yield). The structure of the product was confirmed by 1H-NMR (300 MHz, DMSO-d6): δ 2.41 (3H, s, CH3), 3.45 (4H, t, J = 6.9 Hz, CH2Cl), 3.72 (4H, t, J = 6.9 Hz, CH2N), 7.44 (2H, d, J = 8.2 Hz, ArH), 7.75 (2H, d, J = 8.2 Hz, ArH).

References

[1] Journal of Molecular Structure, 2009, vol. 923, # 1-3, p. 132 - 140
[2] Patent: EP1714961, 2006, A1. Location in patent: Page/Page column 18
[3] Patent: WO2013/175499, 2013, A2. Location in patent: Page/Page column 23
[4] Patent: US2014/179713, 2014, A1. Location in patent: Paragraph 0085
[5] RSC Advances, 2015, vol. 5, # 118, p. 97205 - 97211

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Preparation Products And Raw materials

Raw materials

Diethanolamine Tosyl chloride Thionyl chloride Bis(2-chloroethyl)amine hydrochloride Dichloromethane

Pyridine

1of2

Preparation Products

4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carboxylic acid

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Suppliers

Global( 181)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	12875	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49730	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Alfa Chemistry		info@alfa-chemistry.com	United States	2344	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Alfa Chemistry	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58

View Lastest Price from N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE 42137-88-2	US $1.00 / KG	1KG	98%	100KG	Career Henan Chemical Co

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE
42137-88-2
US $1.00 / KG
98%
Career Henan Chemical Co

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Spectrum

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE(42137-88-2)¹HNMR N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE(42137-88-2)¹HNMR

42137-88-2(N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE)Related Search:

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N,N-DIMETHYL-P-TOLUENESULFONAMIDE Ethyl-p-toluenesulfonamide -EthylbenzenesulfonaMide N,N-Diethyl-4-methylbenzenesulfonamide N-Methyl-p-toluenesulfonamide

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Nornitrogen mustard 4-[BIS-(2-CHLORO-ETHYL)-SULFAMOYL]-BENZOIC ACID N1,N1-DI(2-CHLOROALLYL)-4-METHYLBENZENE-1-SULFONAMIDE AKOS 360

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LABOTEST-BB LT00455209 N-N-BIS(BETA-CHLOROETHYL)-P-TOLUENESULFONAMIDE N,N-BIS(B-CHLOROETHYL)-P-TOLUENESULFONAMIDE N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULPHONAMIDE N,N-BIS(2-CHLOROETHYL)-4-METHYLBENZENESULFONAMIDE Benzenesulfonamide, N,N-bis(2-chloroethyl)-4-methyl- N,N-Bis(-chloroethyl)-p-toluenesulfonamide N,N-Bis-(2-chloroethyl)-p-toluenesulfonamide, tech., 90% N,N-Bis-(2-chloroethyl)-p-toluenesulfonamide,90%,tech. N,N-Bis(2-chloroethyl)-4-methylbenzensulfonamide N,N-Bis(2-chloroethyl)-p-toluenesulfonaMide, Technical Grade 90% NSC 49364 N,N-Bis(2-chloroethyl)-p-toluenesulfonaMide,TechnicalGrade90% N,N-Bis(2-chloroethyl) N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE N,N-Bis(2-chloroethyl)-p-toluenesulfonamide > DK780 N,N-Bis-2-chloroethyl p-toluenesulfonic acid ammonium 42137-88-2 4237-88-2 C11H15Cl12NO2S C11H15Cl2NO2S Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Phenyls & Phenyl-Het Phenyls & Phenyl-Het