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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide structure

CAS No.: 302964-24-5

Chemical Name:: 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Synonyms: EOS-61515;2-Amino-N-(2-chL;Dasatinib Int N-2;The dimer impurity;Dasatinib IMpurity 2;Dasatinib Impurity L;Dasatinib Impurity09;Dasatinib Impurity 27;Dasatinib Impurity 65;dasatinib interMediate

CBNumber:: CB61090897

Molecular Formula:: C11H10ClN3OS

Molecular Weight:: 267.73

MDL Number:: MFCD10000630

MOL File:: 302964-24-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:58:41

Product description	Number	Pack Size	Price
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide >98.0%(GC)(T)	A2773	1g	$108
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide >98.0%(GC)(T)	A2773	5g	$163
2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide	TRC-A603910-1G	1g	$268
2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide	TRC-A603910-10G	10g	$1943
2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide ≥98%	CS-0020987	5g	$15
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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Properties

Melting point	208.0 to 212.0 °C
Boiling point	362.0±37.0 °C(Predicted)
Density	1.474±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Sparingly)
form	powder to crystal
pka	11.09±0.70(Predicted)
color	White to Light yellow
InChI	InChI=1S/C11H10ClN3OS/c1-6-3-2-4-7(12)9(6)15-10(16)8-5-14-11(13)17-8/h2-5H,1H3,(H2,13,14)(H,15,16)
InChIKey	VVOXTERFTAJMAA-UHFFFAOYSA-N
SMILES	S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1N
CAS DataBase Reference	302964-24-5(CAS DataBase Reference)
FDA UNII	VG8Y584N6R

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

HS Code

29333990

REACH Registrations

Inactive

NFPA 704

	0
1		0

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide price More Price(79)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2773	2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide >98.0%(GC)(T)	302964-24-5	1g	$108	2026-04-30	Buy
TCI Chemical	A2773	2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide >98.0%(GC)(T)	302964-24-5	5g	$163	2026-04-30	Buy
TRC	TRC-A603910-1G	2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide	302964-24-5	1g	$268	2026-06-03	Buy
TRC	TRC-A603910-10G	2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide	302964-24-5	10g	$1943	2026-06-03	Buy
ChemScene	CS-0020987	2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide ≥98%	302964-24-5	5g	$15	2026-06-04	Buy

Product number	Packaging	Price	Buy
A2773	1g	$108	Buy
A2773	5g	$163	Buy
TRC-A603910-1G	1g	$268	Buy
TRC-A603910-10G	10g	$1943	Buy
CS-0020987	5g	$15	Buy

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Chemical Properties,Uses,Production

Description

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide is a chemical compound characterized by its thiazole ring. This compound features an amino group (-NH2) and a carboxamide group (-C(=O)NH2), contributing to its potential as a bioactive molecule, making it of interest in medicinal chemistry and drug development.

Uses

2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide, is a precursor in the synthesis of Dasatinib (D193600), a protein tyrosine kinase inhibitor, and also for 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives, used as potent and selective anti-tumor drugs.

Synthesis

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide is synthesised using Tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-YL)carbamate as a raw material by chemical reaction. The specific synthesis steps are as follows:
To the stirred solution of trifluoroacetic acid (TFA) (250.0 mL) added tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)carbamate 23 (25.0 g, 0.07 mol) and stirred for 2h at 25-30°C. Reaction completion was confirmed by TLC, distilled the TFA and the residue was diluted with ethyl acetate (EtOAc),(250.0 mL). Ethyl acetate layer was washed with saturated NaHCO3 solution (2 X 25.0 mL), water, followed bysaturated NaCl solution (125.0 mL). Ethyl acetate layer was dried over Na2SO4 and concentrated. The residual mass on treatment with methyl tert-butyl ether (250.0) gave 9 (16.2 g, 89percent) [11].IR (KBr, cm-1): 3382.4, 3284.85 (N-H), 1627.02 (C=O), 1644; 1H NMR spectrum (400 MHz, DMSO-d6), δ, ppm(J, Hz): 9.63 (s, 1H, thiazole-H), 7.86 (s, 1H), 7.60 (s, 2H, -NH2), 7.38 (dd, 1H, J =7.5, 4.02, Ar-H), 7.20-7.22 (m,2H, J =7.5, Ar-H), 2.20 (s, 3H, Ar-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), δ, ppm: 172.2, 159.6, 143.2,138.9, 133.7, 132.5, 129.0, 128.0, 127.0, 120.7 and 18.3; MS (ESI) m/z 268.0 [M + H] + [11].
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide synthesis

References

[1] Patent: WO2005/77945, 2005, A2. Location in patent: Page/Page column 51

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide synthesis

Synthesis of 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide from Dasatinib

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Preparation Products And Raw materials

Raw materials

2-Chloro-6-methylaniline N-TRIPHENYLMETHYLTHIOUREA Ethyl 2-aminothiazole-5-carboxylate Dasatinib (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide

3-Ethoxyacryloyl chloride Carbamimidothioic acid N-Bromosuccinimide 1,4-Dioxane Water

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Preparation Products

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Dasatinib

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Suppliers

Global( 434)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Huanfu Industrial Co.，（Shanghai）Ltd.	+86-18001856580	2415195517@qq.com	China	43	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3364	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5229	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
Huanfu Industrial Co.，（Shanghai）Ltd.	58
RongNa Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-04	2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 302964-24-5	$10.00	1ASSAYS	99%	1 ton	RongNa Biotechnology Co.,Ltd
2026-05-28	2-Amino-N- (2-chloro-6-methylphenyl) Thiazole-5-Carboxamide 302964-24-5	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2025-09-25	2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 302964-24-5	$6.00	1KG	99%		Henan Fengda Chemical Co., Ltd

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-24-5
$10.00
99%
RongNa Biotechnology Co.,Ltd

2-Amino-N- (2-chloro-6-methylphenyl) Thiazole-5-Carboxamide
302964-24-5
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-24-5
$6.00
99%
Henan Fengda Chemical Co., Ltd

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Spectrum

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(302964-24-5)¹HNMR

302964-24-5(2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide)Related Search:

Dasatinib Impurity 33 N-Deshydroxyethyl Dasatinib Dacomitinib (PF299804) Methyl 2-aminothiazole-5-carboxylate ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)THIAZOLE-5-CARBOXYLATE

2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 2-Chloro-6-methylaniline (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Dasatinib monohydrate (E)-3-Ethoxyacryloyl chloride

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Dasatinib Epichlorohydrin N-Methylformamide Glycine

N,N-Dimethylformamide Aminoethoxyvinyl glycine hydrochloride 2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid

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2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 98% Dasatinib IMpurity 2 2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carboxiMide) 2-Amino-5-[(2-chloro-6-methylphenyl)carbamoyl]-1,3-thiazole, 2-Amino-5-[(6-chloro-o-tolyl)carbamoyl]-1,3-thiazole 5-ThiazolecarboxaMide,2-aMino-N-(2-chloro-6-Methylphenyl) Dasatinib Int N-2 2-AMino-N-(2-chloro-6-Meth 2-AMino-N-(2-chloro-6-Methylphenyl)-5-thiazolecarboxaMide 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(Intermediate of Dasatinib) 2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE EOS-61515 The dimer impurity Dasatinib Impurity 27 2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carb 2-aMino-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide dasatinib interMediate 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide > 2-Amino-N-(2-chL Dasatinib Aminothiazole Impurity 2- Amino-N - (2-chloro-6-methylphenyl) thiazole-5-carboxylamide Dasatinib Impurity L 2-Amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide 2-Amino-N-(2-chloro-6-methylphenyl)thiazol-5-carboxamide 2-Amino-N - (2-chloro-6-methylphenyl) -5-thiazolamide Dasatinib EP Impurity-A 2-Amino-Ni-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Dasatinib Impurity 65 Dasatinib Impurity09 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(Dasatinib intermediate) 302964-24-5 392064-08-5 Dasatinib API intermediates