Hexanoic acid, 4-methyl-5-oxo-, sodium salt (1:1)
- CAS No.
- 1415683-79-2
- Chemical Name:
- Hexanoic acid, 4-methyl-5-oxo-, sodium salt (1:1)
- Synonyms
- EGR240;ERG240;Hexanoic acid, 4-methyl-5-oxo-, sodium salt (1:1)
- CBNumber:
- CB610985780
- Molecular Formula:
- C7H13NaO3
- Molecular Weight:
- 168.17
- MDL Number:
- MOL File:
- 1415683-79-2.mol
Hexanoic acid, 4-methyl-5-oxo-, sodium salt (1:1) Chemical Properties,Uses,Production
Uses
ERG240 is an oral active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor. ERG240 can be used for the research of cancer, rheumatoid arthritis, and bone disease[1].
in vivo
ERG240 (500 mg/kg, i.p., administered 30 min before and 8 h after LPS injection) significantly decreases pro-inflammatory response and increases anti-inflammatory transcriptomic features in LPS (HY-D1056)-induced acute inflammation C57BL/6 mouse model[2]. ERG240 (720 mg/kg and 1000 mg/kg, p.o., once daily for 3 weeks (720 mg/kg) and 4 weeks (1000 mg/kg)) significantly alleviates inflammation and joint destruction in the collagen-induced arthritis DBA/1 mouse model[2]. ERG240 (500 mg/kg, p.o., once daily for 10 days) significantly reduces the severity of inflammation and interstitial fibrosis in the NTN WKY rat model induced by nephrotoxic serum[2].
| Animal Model: | LPS (HY-D1056)-induced acute inflammation C57BL/6 mouse model[2] |
| Dosage: | 500 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), administered 30 min before and 8 h after LPS injection |
| Result: | Reduced Irg1 mRNA and protein levels along with itaconate production. |
| Animal Model: | Collagen (HY-NP102)-induced arthritis (CIA) DBA/1 mouse model[2] |
| Dosage: | 720 and 1000 mg/kg |
| Administration: | Oral gavage (p.o.), once daily for 3 weeks (720 mg/kg) and 4 weeks (1000 mg/kg) |
| Result: | Significantly reduced inflammation, cartilage damage, pannus formation, and bone resorption in CIA model; decreased serum levels of pro-inflammatory markers TNF and RANKL. |
| Animal Model: | Nephrotoxic nephritis (NTN) WKY rat model induced by nephrotoxic serum (NTS) injection[2] |
| Dosage: | 500 mg/kg |
| Administration: | Oral gavage (p.o.), once daily for 10 days |
| Result: | Reduced glomerular crescent formation, proteinuria, serum creatinine, and collagen type I levels. |
References
[1] Papathanassiu, et al. Methods for treatment of cancer, inflammatory autoimmune disorders and bone diseases using branched-chain amino acid aminotransferase-1 (BCAT1) inhibitors. Patent. WO2012173987.
[2] Papathanassiu AE, et al. BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases. Nat Commun. 2017 Jul 12;8:16040. DOI:10.1038/ncomms16040
[3] Papathanassiu A E, et al. Inhibition of BCAT1 suppresses the expression of pro-metastatic proteins and reduces cancer metastasis[J]. Cancer Research, 2014, 74(19_Supplement): 2683-2683.
Hexanoic acid, 4-methyl-5-oxo-, sodium salt (1:1) Preparation Products And Raw materials
Raw materials
Preparation Products
Hexanoic acid, 4-methyl-5-oxo-, sodium salt (1:1) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32433 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3210 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2680 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17721492509; 17721492509 | 643638326@qq.com | China | 4999 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-58851090 17714375163 | 2881759498@qq.com | China | 13011 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
| Selleck Chemicals | 400-668-6834 | info@selleck.cn | China | 6071 | 58 |
