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BOC-L-4-Fluorophe

BOC-L-4-Fluorophe structure

CAS No.: 41153-30-4

Chemical Name:: BOC-L-4-Fluorophe

Synonyms: Boc-L-4-F-Phe;BOC-P-F-PHE-OH;BOC-L-PHE(4-F);BOC-PHE(P-F)-OH;BOC-PHE(4-F)-OH;Boc-L-4-flourophe;BOC-L-PHE(4-F)-OH;BOC-L-4-FLUOROPHE;BOC-4-FLUORO-L-PHE;RARECHEM BK PT 0032

CBNumber:: CB6116369

Molecular Formula:: C14H18FNO4

Molecular Weight:: 283.3

MDL Number:: MFCD00079672

MOL File:: 41153-30-4.mol

MSDS File:: SDS

Last updated:2025-09-09 10:27:52

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BOC-L-4-Fluorophe Properties

Melting point	83-86 °C
alpha	8 º (c=1,MeOH)
Boiling point	431.2±40.0 °C(Predicted)
Density	1.1918 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	3.87±0.10(Predicted)
color	White
optical activity	8.8°(C=1.00g/100ml MEOH)
BRN	4323475
InChI	InChI=1S/C14H18FNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-4-6-10(15)7-5-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1
InChIKey	RCXSXRAUMLKRRL-NSHDSACASA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(F)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference	41153-30-4(CAS DataBase Reference)
UNSPSC Code	12352209

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

Safety Statements

24/25

WGK Germany

Hazard Note

Irritant/Keep Cold

HS Code

29242990

NFPA 704

	1
0		0

BOC-L-4-Fluorophe price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	15352	Boc-Phe(4-F)-OH ≥99.0% (TLC)	41153-30-4	1g	$191	2023-06-20	Buy
Sigma-Aldrich	15352	Boc-Phe(4-F)-OH ≥99.0% (TLC)	41153-30-4	5g	$316	2023-06-20	Buy
TCI Chemical	B3304	N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine >98.0%(T)	41153-30-4	1g	$65	2025-07-31	Buy
TCI Chemical	B3304	N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine >98.0%(T)	41153-30-4	5g	$259	2025-07-31	Buy
Frontier Specialty Chemicals	JK120726	Boc-L-4-flourophenylalanine 99%	41153-30-4	5g	$429	2021-12-16	Buy

Product number	Packaging	Price	Buy
15352	1g	$191	Buy
15352	5g	$316	Buy
B3304	1g	$65	Buy
B3304	5g	$259	Buy
JK120726	5g	$429	Buy

BOC-L-4-Fluorophe Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

Boc-Phe(4-F)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

1132-68-9

41153-30-4

General procedure for the synthesis of Boc-L-4-fluorophenylalanine from di-tert-butyl dicarbonate and (S)-2-amino-3-(4-fluorophenyl)propionic acid: (S)-2-amino-3-(4-fluorophenyl)propionic acid (1.97 g, 10 mmol) was dissolved in a mixture of dioxane (20 mL), water (20 mL), and 1 M NaOH (10 mL), stirred and cooled in an ice water bath. Di-tert-butyl dicarbonate (2.4 g, 11 mmol) was added slowly and the reaction mixture was continued to be stirred for 6 hours at room temperature. Upon completion of the reaction, the solution was concentrated under reduced pressure to about 15-20 mL and then cooled in an ice water bath. The concentrate was covered with ethyl acetate (~30 mL) and acidified to pH 2-3 with the addition of dilute KHSO4 solution. the aqueous phase was separated and extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give a waxy solid product. Yield: 2.115 g (7.25 mmol, 72.5% yield). The product was characterized by 1H NMR and MALDI-TOF mass spectrometry: 1H NMR (DMSO-d6, 400 MHz, ppm): δ 12.60 (s, 1H, COOH), 7.29-7.25 and 7.11-7.07 (m, 4H, aromatic protons), 4.10-3.00 (m, 1H, CH), 3.03-2.77 ( m, 2H, CH2), 1.33 (s, 9H, Boc). MALDI-TOF (Substrate: α-cyano-4-hydroxycinnamic acid (CHCA)): m/z = [M + H]+ 284.12 (calculated), 284.29 (observed), [M + Na]+ 306.11 (calculated), 306.25 (observed).

References

[1] Chemical Communications, 2014, vol. 50, # 76, p. 11154 - 11157
[2] Patent: WO2017/42805, 2017, A1. Location in patent: Page/Page column 24; 25
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099
[4] Bioorganic and Medicinal Chemistry, 1996, vol. 4, # 10, p. 1733 - 1745

BOC-L-4-Fluorophe Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate L-4-Fluorophenylalanine Sodium hydroxide 1,4-Dioxane Water

Preparation Products

BOC-L-4-Fluorophe Suppliers

Global( 248)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	9029	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from BOC-L-4-Fluorophe manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-08	Boc-L-4-Fluorophenylalanine 41153-30-4	US $2.20-8.80 / kg	1kg	99%min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2019-09-02	BOC-L-4-Fluorophe 41153-30-4	US $7.00 / KG	1KG	99%	JD 411	Career Henan Chemical Co

Boc-L-4-Fluorophenylalanine
41153-30-4
US $2.20-8.80 / kg
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

BOC-L-4-Fluorophe
41153-30-4
US $7.00 / KG
99%
Career Henan Chemical Co

BOC-L-4-Fluorophe Spectrum

BOC-L-4-Fluorophe(41153-30-4)¹HNMR

41153-30-4(BOC-L-4-Fluorophe )Related Search:

N-(tert-Butoxycarbonyl)-L-phenylalanine N-Carbobenzyloxyglycine EC 2.6.1.2 tert-Butanol D-Phenylalanine

DL-Phenylalanine Phenprobamate Boc-Aib-OH D-Alanine BOC-L-3,4-Difluorophe

BOC-D-3-FLUOROPHE BOC-L-2-FLUOROPHE BOC-L-4-Methylphe L-Phenylalanine BOC-GLY-LEU-OH

BOC-L-PENTAFLUOROPHENYLALANINE (S)-N-Boc-(4-Pyridyl)alanine BOC-L-4-Chlorophe

1of4

N-alpha-t-Butyloxycarbonyl-4-fluoro-L-phenylalanine (S)-N-BOC-4-FLUOROPHENYLALANINE, 95%, 98% EE (S)-N-BOC-4-Fluorophenylalanine, 98% ee Boc-L-4-Fluoro-phe-OH N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine L-Phenylalanine,N-[(1,1-diMethylethoxy)carbonyl]-4-fluoro- Boc-L-Phe(4-F) -OH Boc-4-Fluoro-L-Phenylalanine N-Boc-4-fluoro-L-phenylalanine Boc-Phe(4-F)-OH Boc-4-fluoro-L-phenylalanine Boc-p-fluoro-Phe-OH N-(tert-butoxycarbonyl)-p-fluoro-L-phenylalanine N-Boc-4-fluoro-L-phenylalanine, 95% Boc-L-4-flourophenylalanine Boc-L-4-flourophe Boc-Phe(4-F)-OH >=99.0% (TLC) (S)-2-((tert-butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid (Tert-Butoxy)Carbonyl Phe(4-F)-OH (2S)-3-(4-fluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid BOC-P-F-PHE-OH (S)-Boc-2-amino-3-(4-fluorophenyl)propionic acid Boc-4-fluoro-L-phenylalanine≥ 99% (HPLC) Boc-p-fluoro-L-Phe-OH N-Boc-4-fluoro-L-phenylalanine,99%e.e. N-ALPHA-T-BOC-4-FLUORO-L-PHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-(4-FLUORO)-L-PHENYLALANINE N-ALPHA-T-BUTYLOXYCARBONYL-L-4-FLUOROPHENYLALANINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-FLUOROPHENYLALANINE RARECHEM BK PT 0032 tert-butoxycarbonyl-l-4-fluorophenylalanine (S)-N-BOC-4-FLUOROPHENYLALANINE (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID BOC-(S)-2-AMINO-3-(4'-FLUOROPHENYL)PROPANOIC ACID BOC-L-PHE(4-F) BOC-L-PHE(4-F)-OH BOC-P-FLUORO-L-PHENYLALANINE BOC-P-FLUORO-PHENYLALANINE BOC-P-FLUORO-PHE-OH BOC-PHE(P-F)-OH BOC-PHE(4-F)-OH BOC-4-FLUORO PHENYLALANINE BOC-4-FLUORO-PHE-OH BOC-4-FLUORO-L-PHE BOC-4-FLUORO-L-PHENYLALANINE BOC-L-4-FLUOROPHE BOC-L-4-FLUOROPHENYLALANINE N-TERT-BUTOXYCARBONYL-4-FLUOROPHENYL-L-ALANINE L-4-FLUOROPHENYLALANINE, BOC PROTECTED Boc-4-Fluoro-L-Phe-OH N-alpha-tert-Butoxycarbonyl-3-(4-fluorophenyl)-L-al BOC-L-4-FLUOROPHENYLALANINE,98% 4-Fluoro-L-phenylalanine,N-BOCprotected 1-diMethylethoxy)carbonyl]-4-fluoro- Boc-L-4-F-Phe 2-[(4-fluorophenyl)methyl]-3-[(2-methylpropan-2-yl)oxy]-3-oxopropanoic acid N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine> BOC-L-4-Fluorophe USP/EP/BP Venadaparib Impurity 67 (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid - [B91613] N-Boc-4-fluoro-L-phenylalanine