UCM-1306
- CAS No.
- 2258608-78-3
- Chemical Name:
- UCM-1306
- Synonyms
- UCM1036;UCM-1306
- CBNumber:
- CB612253214
- Molecular Formula:
- C14H14FNO2S
- Molecular Weight:
- 279.33
- MDL Number:
- MOL File:
- 2258608-78-3.mol
UCM-1306 Chemical Properties,Uses,Production
Uses
UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD)[1].
in vivo
UCM-1306 (2-(Fluoromethoxy)-4'-(S-methylsulfonimidoyl)-1,1'-biphenyl; 5 mg/kg; p.o.; C57BL/6J mice) has good brain penetration and oral availability. Plasma concentration can be quantified for up to 8 h with Tmax at 0.5 h[1].
UCM-1306 (1 mg/kg; ip) enhances cocaine-induced hyperlocomotion in adult mice[1].
UCM-1306 (1 mg/kg; ip) helps consolidate long-term memory formation[1].
| Animal Model: | Adult C57BL/6J mice with cocaine-induced hyperactivity model[1] |
| Dosage: | 1 mg/kg; cocaine (20 mg/kg, sc) |
| Administration: | Intraperitoneal injection |
| Result: | Increased cocaine-induced hyperlocomotion, suggesting an in vivo potentiation of DA action at the D1R. |
| Animal Model: | Adult C57BL/6J mice |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Increased memory trace in C57BL/6J mice. |
References
[1] García-Cárceles J, et, al. 2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. J Med Chem. 2022 Sep 22;65(18):12256-12272. DOI:10.1021/acs.jmedchem.2c00949
UCM-1306 Preparation Products And Raw materials
Raw materials
Preparation Products
UCM-1306 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6772 | 55 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1942 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 407 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29545 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
| Guangzhou Taozhu Biotechnology Co., Ltd | 4008200310 | CHINA | 111 | 58 |
