Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)-
- CAS No.
- 99759-48-5
- Chemical Name:
- Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)-
- Synonyms
- O-benzoylheteratisine;6-benzoylheteratisine;Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth;Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)-;Inhibitor,6Benzoylheteratisine,Sodium Channel,inhibit,6-Benzoylheteratisine,Na+ channels,Na channels,6 Benzoylheteratisine;8H-13,3,6a-Ethanylylidene-7,10-methanooxepino[3,4-i]-1-benzazocin-8-one, 14-(benzoyloxy)-1-ethyltetradecahydro-12a-hydroxy-6-methoxy-3-methyl-, (3R,6S,6aS,7R,7aS,10S,12aS,13R,13aR,14S,15R)-
- CBNumber:
- CB61248058
- Molecular Formula:
- C29H37NO6
- Molecular Weight:
- 495.62
- MDL Number:
- MFCD01937939
- MOL File:
- 99759-48-5.mol
- MSDS File:
- SDS
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)- Properties
| Melting point | 212-214 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 645.9±55.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| pka | 13.38±0.70(Predicted) |
| form | Solid |
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)- Chemical Properties,Uses,Production
Uses
6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na+]i, [Ca2+]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge[1][2].
Hazard
A poison.
References
[1] Gutser UT, et al. The alkaloid 6-benzoylheteratisine inhibits voltage-gated Na+ channels in rat brain synaptosomes. Neuropharmacology. 1998 Sep;37(9):1139-46. DOI:10.1016/s0028-3908(98)00114-2
[2] Ameri A. Effects of the alkaloids 6-benzoylheteratisine and heteratisine on neuronal activity in rat hippocampal slices. Neuropharmacology. 1997 Aug;36(8):1039-46. DOI:10.1016/s0028-3908(97)00095-6
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)- Preparation Products And Raw materials
Raw materials
Preparation Products
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3988 | 66 |
| Shanghai Yihe Biological Technology Co., Ltd. | 021-68882955 17721395025 | 2423903095@qq.com | China | 4991 | 58 |
| Chengdu Alfa Biotechnology Co.,Ltd. | 028-028-85142057 19983342022 | 3005359975@qq.com | China | 1985 | 58 |
| Shanghai Taopu Industrial Co., LTD | 159-00573766 18018507602 | 394643792@qq.com | China | 4315 | 58 |
| Naturewill Biotechnology Co., Ltd. | 028-82632533 18113192475 | 3157321941@qq.com | China | 4993 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | rose.shi@synzest.com | China | 6210 | 58 |
| Chengdu Biopurify Ltd. | 28-82633860 18982077548 | cwb1@biopurify.cn | China | 3842 | 58 |
