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Amprolium

Amprolium structure

CAS No.: 121-25-5

Chemical Name:: Amprolium

Synonyms: Amprolium HCI;AMPROLIUM;AMproliuM, USP;Amprolium [INN:BAN];Amprolium USP/EP/BP;AMPROLIUM USP 26, BPV 98;Venlafaxine Impurity 1-d6;amprolium/amprolium hydrochloride;Amprolium 1000 μg/mL in Acetonitrile:Water;(1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.

CBNumber:: CB6127743

Molecular Formula:: C14H19N4.Cl

Molecular Weight:: 278.79

MDL Number:: MFCD00072061

MOL File:: 121-25-5.mol

TDS File:: TDS

Last updated:2026-06-24 18:39:39

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Amprolium Properties

Melting point	246-248 °C (decomp)
storage temp.	0-6°C
solubility	Soluble in DMSO
form	powder
color	Crystals from methanol + ethanol
Stability	Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
Major Application	pharmaceutical small molecule
InChI	InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
InChIKey	LCTXBFGHZLGBNU-UHFFFAOYSA-M
SMILES	C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.[Cl-]
CAS DataBase Reference	121-25-5(CAS DataBase Reference)
FDA 21 CFR	556.50; 558.55
FDA UNII	71M75T660B
EPA Substance Registry System	Amprolium (121-25-5)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids
Hazard Classifications	Resp. Sens. 1 Skin Sens. 1

Amprolium price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2345	Amprolium Pharmaceutical Secondary Standard; Certified Reference Material	121-25-5	500MG	$205.2	2025-07-31	Buy
aablocks	AA0076YW	Amprolium	121-25-5	5mg	$66	2026-05-28	Buy
aablocks	AA0076YW	Amprolium	121-25-5	10mg	$92	2026-05-28	Buy
aablocks	AA0076YW	Amprolium	121-25-5	50mg	$224	2026-05-28	Buy
aablocks	AA0076YW	Amprolium	121-25-5	100mg	$338	2026-05-28	Buy

Product number	Packaging	Price	Buy
PHR2345	500MG	$205.2	Buy
AA0076YW	5mg	$66	Buy
AA0076YW	10mg	$92	Buy
AA0076YW	50mg	$224	Buy
AA0076YW	100mg	$338	Buy

Amprolium Chemical Properties, Uses, Production

Description

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Chemical Properties

solid

Originator

Neoprol ,SIMB

Uses

Coccidiostat (for poultry).

Uses

Amprolium is an oral coccidiostat, a thiamine analogue, which is used for the prevention and treatment of intestinal coccidiosis . It is used as a feed additive for livestock, sometimes administered in the food or drinking water of puppies and kittens, and in chickens and calves.

Definition

ChEBI: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.

Manufacturing Process

1.9 grams of p-toluene sulfonyl chloride was added gradually with shaking to a cooled (0-5°C) solution of 1.67 grams of 2-n-propyl-4-amino-5-hydroxymethyl pyrimidine in 10 ml of 2-methylpyridine. The reaction mixture, after standing three hours in an ice bath, and 15 hours at room temperature, was evaporated to dryness in vacuo. The residue was dissolved in 20 ml of water, acidified with hydrochloric acid and poured over a column of Amberlite IRA- 400 ion exchange resin on the chloride cycle. The eluate was evaporated to dryness to give a residue of 1-(2-n-propyl-4-amino-5-pyrimidylmethyl)-2- methyl pyridinium chloride hydrochloride. On recrystallization from a methanol-ethanol mixture, the quaternary had melting point 246°C (dec.).

brand name

Amprol [Veterinary] (Merial); Amprovine [Veterinary] (Merial); Corid [Veterinary] (Merial).

Therapeutic Function

Coccidiostatic

Contact allergens

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Side effects

Amprolium is considered one of the safest anticoccidial medications, and adverse reactions such as anorexia or diarrhoea may occur with high doses and prolonged use. Thiamine deficiency can cause central nervous system (CNS) symptoms, but can be reversed with the addition of thiamine to the diet. However, thiamine supplementation may affect the efficacy of the drug.

Safety Profile

When heated to decomposition emits toxic fumes of Cl-.

Amprolium Preparation Products And Raw materials

Raw materials

Hydrochloric acid Tosyl chloride 2-Picoline

Preparation Products

Amprolium Suppliers

Global Suppliers ( 174)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Jihao Biotechnology Co., Ltd.	0531-69958659 15668363232	8598038@qq.com	China	46	58
China Langchem Inc.	0086-21-58956006		China	7798	57
RYSS TECH LTD	400-188-0725 +86 21 34310725 13611771617		China	1999	57
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79
Spectrum Chemical Manufacturing Corp.	021-021-021-67601398-809-809-809 15221380277	marketing_china@spectrumchemical.com	China	9643	60
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7993	58
Shanghai Tombiopharma Chemical Co. Ltd.	13391076197	tombiopharma@163.com	China	4986	55
Zhejiang Haiqiang Chemical Co.,Ltd	0571-86050367 0571-86960370 0571-86050387	info@chinahaiqiangchem.com	China	461	55

Supplier	Advantage
Shandong Jihao Biotechnology Co., Ltd.	58
China Langchem Inc.	57
RYSS TECH LTD	57
Sinopharm Chemical Reagent Co,Ltd.	79
Spectrum Chemical Manufacturing Corp.	60
MedChemexpress LLC	58
Guangzhou Isun Pharmaceutical Co., Ltd	55
TargetMol Chemicals Inc.	58
Shanghai Tombiopharma Chemical Co. Ltd.	55
Zhejiang Haiqiang Chemical Co.,Ltd	55

View Latest Price from Amprolium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	Amprolium USP/EP/BP 121-25-5	$1.10	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2026-06-30	Amprolium 121-25-5		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-05-18	Amprolium 121-25-5		1kg	98%		Hefei Lbao Physical & Chemical Science Co.,Ltd

Amprolium USP/EP/BP
121-25-5
$1.10
99.9%
Dideu Industries Group Limited

Amprolium
121-25-5
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

Amprolium
121-25-5
$0.00
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

121-25-5 (Amprolium) Related Search:

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Methyl Methyl bromide Amprolium Hydrochloride

1of4

AMPROLIUM 1-[[4-Amino-2-propyl-5-pyrimidinyl] methyl]-2-picolinium chloride hydrochloride 1-[2-Propyl-4-amino-5-pyrimidylmethyl]-2-methylpyridinium chloride hydrochloride Pyridinium, 1-(4-amino-2-propyl-5-pyrimidinyl)methyl-2-methyl-, chloride AMPROLIUM USP 26, BPV 98 (1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID. 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride Amprolium [INN:BAN] AMproliuM, USP [5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-yl]amine chloride 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine chloride 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride (1R,2S,4aS,8aS)-1-(hydroxymethyl)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydronaphthalene-1,2-diol Amprolium USP/EP/BP 1-((4-Amino-2-propylpyrimidin-5-yl)methyl)-2-methylpyridin-1-ium chloride amprolium/amprolium hydrochloride Venlafaxine Impurity 1-d6 Amprolium 1000 μg/mL in Acetonitrile:Water Amprolium HCI 121-25-5 C14H19CIN4HCl C14H19ClN4 APIs API's