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CWI1-2 hydrochloride

CWI1-2 hydrochloride Structure
CWI1-2 hydrochloride structure
CAS No.
2408590-37-2
Chemical Name:
CWI1-2 hydrochloride
Synonyms
CWI1-2 HCl;CWI1-2 hydrochloride;CWI1-2 HCL, 10 mM in DMSO;N',N'',2-Tris(5-chloro-2-hydroxybenzylidene)hydrazine-1-carbohydrazonhydrazide hydrochloride;N',N'',2-Tris(5-chloro-2-hydroxybenzylidene)hydrazine-1-carbohydrazonhydrazide hydrochloride;1-[(Z)-(5-chloro-2-hydroxyphenyl)methylideneamino]-2,3-bis[(E)-(5-chloro-2-hydroxyphenyl)methylideneamino]guanidine
CBNumber:
CB613229636
Molecular Formula:
C22H17Cl3N6O3.ClH
Molecular Weight:
556.23
MDL Number:
MOL File:
2408590-37-2.mol
Last updated:2025-09-11 22:01:37
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CWI1-2 hydrochloride Properties

Melting point 241-242 °C
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear
form powder
color white to beige
UNSPSC Code 12352200
NACRES NA.21

CWI1-2 hydrochloride Chemical Properties,Uses,Production

Uses

CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1].

Biological Activity

CWI1-2 is a cell penetrant, potent and selective inhibitor of an m6A reader IGF2BP2 (Insulin-like growth factor 2 mRNA-binding protein 2). CWI1-2 potently inhibits IGF2BP2 interaction with N6-Methyladenosine (m6A) modified target transcripts. CWI1-2 exhibits potent anti-leukemia efficacy in vitro and in vivo.

in vivo

CWI1-2 (5 mg/kg, i.v., once daily, 7-10 days) hydrochloride can significantly delay the onset of leukemia and prolong the survival time of BMT recipient B6.SJL (CD45.1) mice without any loss in body weight[1].

References

[1] Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. DOI:10.1016/j.ccell.2022.10.004

CWI1-2 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

CWI1-2 hydrochloride Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6772 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9848 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62320 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Shaoguan Qicheng Biotechnology Co., Ltd 18122215013 780229652@qq.com China 1286 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-58851090 17714375163 2881759498@qq.com China 13011 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Shaoguan Qicheng Biotechnology Co., Ltd 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 58
Sangon Biotech (Shanghai) Co.,Ltd. 58

View Lastest Price from CWI1-2 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CWI1-2 HCL pictures 2025-09-11 CWI1-2 HCL
2408590-37-2
 US $45.00-163.00 / mg 99.18% 10g TargetMol Chemicals Inc.
  • CWI1-2 HCL pictures
  • CWI1-2 HCL
    2408590-37-2
  • US $45.00-163.00 / mg
  • 99.18%
  • TargetMol Chemicals Inc.

CWI1-2 hydrochloride Spectrum

INDEX NAME NOT YET ASSIGNED(2408590-37-2)1HNMR
CWI1-2 HCl CWI1-2 hydrochloride N',N'',2-Tris(5-chloro-2-hydroxybenzylidene)hydrazine-1-carbohydrazonhydrazide hydrochloride CWI1-2 HCL, 10 mM in DMSO N',N'',2-Tris(5-chloro-2-hydroxybenzylidene)hydrazine-1-carbohydrazonhydrazide hydrochloride 1-[(Z)-(5-chloro-2-hydroxyphenyl)methylideneamino]-2,3-bis[(E)-(5-chloro-2-hydroxyphenyl)methylideneamino]guanidine 2408590-37-2 C22H18Cl4N6O3